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Search Result

Search Results for " clot "

Targets

Others

40

Compounds

2

Natural Products

10

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T4502 BISMUTH SUBGALLATE Dermatol Puder,Bismuth Gallate Others
Bismuth subgallate (Dermatol Puder) is an astringent and antiseptic and is applied to skin diseases such as eczema.
T19786 Hematin Ferrihemate,Ferriheme hydroxide,Ferriheme,Ferrihemic acid Others
Hematin (Ferrihemic acid) is an iron-containing porphyrin. It is used for testing in vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens.
T0182L Clopidogrel hydrogen sulfate (S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel P450 , P2Y Receptor
Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets and platelet adhesion and aggregation.
T4573 Cyclothiazide GluR
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M).
T11852 Linaclotide Guanylate cyclase
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist.
T26804 Biclotymol Others
Biclotymol is used in the study about infectious oropharyngeal diseases.
T21153 Clothianidin TI435,TI-435,TI 435,Celero AChR
Clothianidin (TI 435), an insecticide, acts as an agonist of acetylcholine to stimulate nAChR, thereby activating post-synaptic acetylcholine receptors but not inhibiting AChE.
T6581 Methyclothiazide Duretic,Enduron,Aquatensen Others , Carbonic Anhydrase
Methyclothiazide (Aquatensen) is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.
T13620 Clothixamide Clotixamide Others
Clothixamide（Clotixamide） is a thioxanthene derivative with antipsychotic activity.
T0506 Clotrimazole BAY b 5097,FB 5097 Antibacterial , Antibiotic , Antifection , Autophagy , Antifungal
Clotrimazole (FB 5097), an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol.
TP2068L Cyclotraxin B acetate(1203586-72-4 free base) Trk receptor
Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold...
T23924 Cyclothialidine Ro 09-1437
Cyclothialidine is an inhibitor of DNA gyrase.
TP2068 Cyclotraxin B
Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also sho...
T75832 Cyclotraxin B TFA
Cyclotraxin B TFA, a cyclic peptide, serves as a highly potent and selective non-competitive inhibitor of TrkB, effectively impeding BDNF-triggered TrkB activity without altering BDNF binding affinity, evidenced by an IC...
T69054 Ciclotizolam
Ciclotizolam is a drug which is a thienotriazolodiazepine derivative. It is a partial agonist for the benzodiazepine site of the GABAA receptor, with similar binding affinity to related compounds like brotizolam, but a l...
T66283 1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene octahydrobromide
1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene octahydrobromide is a useful organic compound for research related to life sciences. The catalog number is T66283 and the CAS number is 155148-32-6.
T76231 Cyclotheonellazole A
Cyclotheonellazole A, a macrocyclic peptide naturally occurring, serves as a potent inhibitor of elastase (IC50 = 0.034 nM) and chymotrypsin with an IC50 of 0.62 nM [1] [2].
TP2403 Recanaclotide IW 9179,IW-9179,IW9179
Recanaclotide can be used to treat Gastroparesis, Functional Dyspepsia, and Other Gastrointestinal Disorders.
T39264L Cyclotriazadisulfonamide hydrochloride Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base) HIV Protease
Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.
T69204 Octoclothepin maleate salt
Octoclothepin maleate salt is a D2 dopamine receptor antagonist and 5-HT2 serotonin receptor antagonist.
T11852L Linaclotide acetate MM 416775,MM416775 MD-1100 acetate,Linzess,MM-416775
Linaclotide acetate is used as an oral guanylate cyclase C agonist linaclotide; 14 amino acid peptide for the potential treatment of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.
T68735 Ciclotropium (free base)
Ciclotropium (free base) is quaternary ammonium compound with anticholinergic and parasympatholytic activity. Oral Cyclotropium bromide inhibited fasting and meal-stimulated colonic motility significantly without causing...
T39264 Cyclotriazadisulfonamide CADA,Cyclotriazadisulfonamide
Cyclotriazadisulfonamide (CADA) is a specific inhibitor of HIV entry that targets CD4. It functions by preventing the co-translational translocation of human CD4 (huCD4) into the endoplasmic reticulum (ER) lumen through ...
T23900 Clothiapine LW 2159,HF2159,HF-2159,HF 2159,S-805C
Clothiapine is an atypical antipsychotic of the dibenzothiazepine chemical class.
T17204 UNC0321 Histone Methyltransferase
UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays.
T23764 AZ3976 AZ 3976,AZ-3976 PAI-1
AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.
T31206 Darexaban YM 150,Darexaban, Tanexaban,YM150 Factor Xa
Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati...
T22600 BC 11 hydrobromide Others
The compound is a selective urokinase inhibitor (IC50 = 8.2 μM). It also inhibits clot lysis with no effect on clot formation.
T70810 THR-18
THR-18 is an 18-mer peptide derived from the sequence of human plasminogen activator inhibitor 1 (PAI-1), having the ability to bind to a site of tissue plasminogen activator (tPA) distal to its catalytic site and uncoup...
T78367 Fibrinogen (Bovine)
Fibrinogen (Bovine) is a molecule selectively proteolyzed, assembling into a fibrin clot upon thrombin activation [1].
T82063 Integrin signaling inhibitor, mP13
Integrin Signaling Inhibitor mP13 is a compound that impedes both inside-out and outside-in integrin-mediated signaling processes, such as fibrinogen binding, platelet adhesion, and clot retraction [1].
T35579 PKSI-527
PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 μM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 μM, respect...
T36773 12(S)-HETrE
12(S)-HETrE is produced by 12-lipoxygenase oxidation of dihomo-γ-linolenic acid (DGLA). 12(S)-HETrE is reported to inhibit agonist-mediated platelet activation (IC50 = 40 μM), α granule secretion, integrin αIIbβ3 activat...
T26657 AR-H067637
AR-H067637 is a rapid-binding, reversible and potent (inhibition constant K(i) = 2-4 nM), competitive inhibitor of thrombin, as well as of thrombin bound to fibrin (clot-bound thrombin) or to thrombomodulin. The total am...
T75589 Bitis Cornuta Venom
Bitis Cornuta (Many-horned Adder) Venom, sourced from Bitis Cornuta, comprises snake venom phospholipase A2 (sPLA2) toxins that exhibit anticoagulant properties by inhibiting the prothrombinase complex, consequently prom...
T73855 Thromboxane B1
Thromboxane B1 (TXB1), a member of the Thromboxane B (TXB) family, is a lipid belonging to the eicosanoid family, recognized for its function in blood clot formation (thrombosis) [1].
T35583 Hirudin (54-65; non-sulfated) (trifluoroacetate salt)
Hirudin (54-65; non-sulfated) is a desulfated peptide fragment of hirudin, an anticoagulant produced byH. medicinalis.1It inhibits fibrin clot formation induced by isolated bovine thrombin with an IC50value of 3.7 μM.2 1...
T72113 6-Aminocaproic acid hydrochloride EACA hydrochloride,EACA hydrochloride ; Epsilon-Amino-n-caproic Acid hydrochloride ; 6-Aminohexanoic acid hydrochloride,6-Aminohexanoic acid hydrochloride,Epsilon-Amino-n-caproic Acid hydrochloride
6-Aminocaproic acid hydrochloride, a monoamino carboxylic acid derivative, serves as a potent, orally active antifibrinolytic agent by inhibiting plasmin and plasminogen. It functions through competitive binding to lysin...
T75152 ARC19499
ARC19499, an aptamer, inhibits the tissue factor pathway inhibitor (TFPI), facilitating clot initiation and propagation through the extrinsic pathway. It binds specifically to TFPI, blocking its inhibition of both factor...
T80119 Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) Thrombin
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide with greater thrombin affinity than Hirugen, exhibiting a dissociation constant (K D) of less than 100 nM. This compound acts as an antithromb...

Compounds

BISMUTH SUBGALLATE
T4502
Synonym: Dermatol Puder,Bismuth Gallate
Target: Others
Hematin
T19786
Synonym: Ferrihemate,Ferriheme hydroxide,Ferriheme,Ferrihemic acid
Target: Others
Clopidogrel hydrogen sulfate
T0182L
Synonym: (S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel
Target: P450, P2Y Receptor
Cyclothiazide
T4573
Synonym:
Target: GluR
Linaclotide
T11852
Synonym:
Target: Guanylate cyclase
Biclotymol
T26804
Synonym:
Target: Others
Clothianidin
T21153
Synonym: TI435,TI-435,TI 435,Celero
Target: AChR
Methyclothiazide
T6581
Synonym: Duretic,Enduron,Aquatensen
Target: Others, Carbonic Anhydrase
Clothixamide
T13620
Synonym: Clotixamide
Target: Others
Clotrimazole
T0506
Synonym: BAY b 5097,FB 5097
Target: Antibacterial, Antibiotic, Antifection, Autophagy, Antifungal
Cyclotraxin B acetate(1203586-72-4 free base)
TP2068L
Synonym:
Target: Trk receptor
Cyclothialidine
T23924
Synonym: Ro 09-1437
Target:
Cyclotraxin B
TP2068
Synonym:
Target:
Cyclotraxin B TFA
T75832
Synonym:
Target:
Ciclotizolam
T69054
Synonym:
Target:
1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene octahydrobromide
T66283
Synonym:
Target:
Cyclotheonellazole A
T76231
Synonym:
Target:
Recanaclotide
TP2403
Synonym: IW 9179,IW-9179,IW9179
Target:
Cyclotriazadisulfonamide hydrochloride
T39264L
Synonym: Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base)
Target: HIV Protease
Octoclothepin maleate salt
T69204
Synonym:
Target:
Linaclotide acetate
T11852L
Synonym: MM 416775,MM416775 MD-1100 acetate,Linzess,MM-416775
Target:
Ciclotropium (free base)
T68735
Synonym:
Target:
Cyclotriazadisulfonamide
T39264
Synonym: CADA,Cyclotriazadisulfonamide
Target:
Clothiapine
T23900
Synonym: LW 2159,HF2159,HF-2159,HF 2159,S-805C
Target:
UNC0321
T17204
Synonym:
Target: Histone Methyltransferase
AZ3976
T23764
Synonym: AZ 3976,AZ-3976
Target: PAI-1
Darexaban
T31206
Synonym: YM 150,Darexaban, Tanexaban,YM150
Target: Factor Xa
BC 11 hydrobromide
T22600
Synonym:
Target: Others
THR-18
T70810
Synonym:
Target:
Fibrinogen (Bovine)
T78367
Synonym:
Target:
Integrin signaling inhibitor, mP13
T82063
Synonym:
Target:
PKSI-527
T35579
Synonym:
Target:
12(S)-HETrE
T36773
Synonym:
Target:
AR-H067637
T26657
Synonym:
Target:
Bitis Cornuta Venom
T75589
Synonym:
Target:
Thromboxane B1
T73855
Synonym:
Target:
Hirudin (54-65; non-sulfated) (trifluoroacetate salt)
T35583
Synonym:
Target:
6-Aminocaproic acid hydrochloride
T72113
Synonym: EACA hydrochloride,EACA hydrochloride ; Epsilon-Amino-n-caproic Acid hydrochloride ; 6-Aminohexanoic acid hydrochloride,6-Aminohexanoic acid hydrochloride,Epsilon-Amino-n-caproic Acid hydrochloride
Target:
ARC19499
T75152
Synonym:
Target:
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
T80119
Synonym:
Target: Thrombin
Cat No. Product Name Synonyms Targets
T0881 6-Aminocaproic acid EACA,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-​Aminocaproic acid Others
6-Aminocaproic acid (EACA) is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
T31141 Cyclotheonamide A
Cyclotheonamide A is a cyclic peptide isolated from the marine sponge Theonella.

Natural Products

6-Aminocaproic acid
T0881
Synonym: EACA,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-​Aminocaproic acid
Target: Others
Cyclotheonamide A
T31141
Synonym:
Target:

Recombinant Proteins

Species：
Human (5)
Mouse (2)
Carcinoscorpius rotundicauda (1)
Rat (1)
Tachypleus tridentatus (1)
Expression System：
HEK293 (5)
E. coli (3)
Human Cells (2)
Tag：
His (5)
C-6His (2)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
N-terminal 6xHis-SUMO-tagged (1)
N-terminal 6xHis-tagged (1)
Cat No. Product Name Species Expression System
TMPH-03618 Clotting factor C Protein, Tachypleus tridentatus, Recombinant (His & Myc) Tachypleus tridentatus E. coli
Clotting factor C Protein, Tachypleus tridentatus, Recombinant (His & Myc) is expressed in E. coli.
TMPH-00346 Limulus clotting factor C Protein, Carcinoscorpius rotundicauda, Recombinant (His) Carcinoscorpius rotundicauda E. coli
This enzyme is closely associated with an endotoxin-sensitive hemolymph coagulation system which may play important roles in both hemostasis and host defense mechanisms. Its active form catalyzes the activation of factor...
TMPY-04830 GAS6 Protein, Mouse, Recombinant (His) Mouse HEK293
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin ...
TMPY-02185 Coagulation factor XIII B/F13B Protein, Human, Recombinant (His) Human HEK293
Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 1 Sushi ...
TMPH-01508 HABP2 Protein, Human, Recombinant (His & SUMO) Human E. coli
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fib...
TMPJ-01116 HABP2 Protein, Human, Recombinant (His) Human Human Cells
Hyaluronan-binding protein 2（HABP2） is an extracellular serine protease which binds hyaluronic acid. It secreted as an inactive single-chain precursor and is then activated to a heterodimeric form, which consists of a 50...
TMPY-01026 Alpha 2 Antiplasmin/SerpinF2 Protein, Mouse, Recombinant (His) Mouse HEK293
SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily. SerpinF2 is the principal physiological inhibitor of serine protease plasmin, and as well as, an efficient inhibitor of try...
TMPY-04860 Alpha 2 Antiplasmin/SerpinF2 Protein, Rat, Recombinant (His) Rat HEK293
SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily. SerpinF2 is the principal physiological inhibitor of serine protease plasmin, and as well as, an efficient inhibitor of try...
TMPJ-00535 F13A Protein, Human, Recombinant (His) Human Human Cells
Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, ...
TMPY-01398 Alpha 2 Antiplasmin/SerpinF2 Protein, Human, Recombinant (His) Human HEK293
SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily. SerpinF2 is the principal physiological inhibitor of serine protease plasmin, and as well as, an efficient inhibitor of try...
Cat No. Product Name
L7500 Coagulation and Anticoagulation Compound Library

154 compounds
A unique collection of 154 procoagulation and anticoagulation related compounds for high throughput screening (HTS) and high content screening (HCS);

Libraries

Coagulation and Anticoagulation Compound Library
L7500
Compounds: 154
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