chelator

Chelator 1a has antifungal activity, inhibiting Aspergillus and Candida, and can be used to study fungal infections and cancer.

Deferasirox (CGP-72670) is an oral iron chelating agent used to treat chronic iron overload.

Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) is a metal chelator and a nontoxic inhibitor of CMV replication, as well as a useful antidote in cases of acute cadmium intoxication.

Ethylenebis(oxyethylenenitrilo)tetraacet is a diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.

BAPTA is a neuroprotective agent in cerebral ischemia, acting as an intercellular Ca2+ chelator.

BLT-1 is a scavenger receptor BI (SR-BI)inhibitor.

Deferitrin (GT-56-252) is an iron chelator. It potentially for the treatment of thalassemia and iron overload.

L-Mimosine (Leucenol) is an antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca and acts as an iron chelator.

VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells.

HBED (CHELII) is an iron chelator and can be used in research on the treatment of chronic iron overload and acute iron poisoning.

Neocuproine is a copper(I) chelator that enhances the purinergic component of vasoconstriction induced by electric field stimulation, and is often used as a ligand reagent and copper ion detector.Neocuproine forms stable complexes with copper ions and can play a catalytic role in certain chemical reactions and analytical methods.Neocuproine acts as a redox-active on the iron and cobalt ligand platform for protection against oxidative damage in NSC34 cells.

Phytic acid sodium salt (Sodium phytate hydrate) is known to function as a [PO4]3- storage depot and a precursor for other inositol phosphates and pyrophosphates. It is a potent chelator of divalent and trivalent cations in vitro.

SP-420 is a novel orally active iron chelator.

Dp44mT, a effective iron chelator, has selective antitumor activity.

VK-28 is a brain permeable iron chelator with neuroprotection. VK-28 inhibits basal as well as iron-induced mitochondrial lipid peroxidation.

Homobutein (3-O-Methylbutein) is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.

Cu(I) chelator 1 (Compound LH2) is a chelating agent specifically targeting the Cu(I) redox state. It inhibits the production of ROS.

Deferoxamine (Desferrioxamine B) is an iron chelator. Deferoxamine can be used to reduce the accumulation and deposition of iron in tissues. Deferoxamine can improve neurological dysfunction by inhibiting ferroptosis and neuroinflammation after traumatic brain injury. It has antioxidant, anti-proliferation and anti-tumor activities, and can induce the production of HIF-1α, apoptosis and autophagy in cancer cells. It can be used to treat acute iron toxicity and COVID-19 related diseases.

Deferoxamine Mesylate (DFOM) is an iron chelator and ferroptosis inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF-1α levels and induces apoptosis.

Macropa-NH2 is a bifunctional analog of macropa, a carrier molecule that is often coupled to antibodies and is often used as a chelator in cancer research.

Deferitazole (FBS 0701) is a novel and orally active, selective and high affinity iron chelator.

Norathiol (N-methyl-N-dithiocarboxyglucamine) is an antidote for cadmium poisoning and a metal chelator that promotes the excretion of 109Cd and can be used in the treatment of cadmium poisoning.

MDCG sodium (N-methyl-N-dithiocarboxyglucamine sodium) is a metal chelator that promotes biliary excretion of Cd.

Emeramide (BDTH2) is a thiol-redox antioxidant. It is also a heavy metal chelator.