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btk inhibitor 1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    54
    TargetMol | Inhibitors_Agonists
BTK inhibitor 1
T353302230724-66-8In house
BTK inhibitor 1 (Compound 27) is a BTK inhibitor (IC50: 0.11 nM) with an inhibitory effect on B-cell activation in hWB with an IC50 of 2 nM.
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8-10weeks
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Btk inhibitor 1 hydrochloride
T36297
Btk inhibitor 1 Hcl is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor.IC50 value:Target: BtkFrom PCT Int. Appl. (2012), WO 2012158843 A2 20121122. [1]. PCT Int. Appl. (2012), WO 2012158843 A2 20121122.
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BTK inhibitor 17
T97061858206-76-4
BTK inhibitor 17 is a potent irreversible Bruton's tyrosine kinase (BTK) inhibitor with an IC50 value of 2.1 nM, suitable for use in rheumatoid arthritis studies.
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TargetMol | Inhibitor Sale
BTK inhibitor 10
T106272241732-30-7
BTK inhibitor 10 is a potent and orally active compound with potential applications in rheumatoid arthritis treatment.
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6-8 weeks
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BTK inhibitor 13
T106282376726-26-8
BTK inhibitor 13 (compound 8) is a potent and selective BTK inhibitor with an IC50 of 1.2 nM.
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8-10 weeks
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BTK inhibitor 19
T401852557174-19-1
BTK inhibitor 19 is a highly selective, covalent BTK inhibitor (IC 50 = 2.7 nM).
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BTK inhibitor 18
T64042
BTK inhibitor 18 is a selective, potent, covalent, orally active Btk inhibitor (IC50: 142 nM) that exhibits anti-inflammatory effects.
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10-14 weeks
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Remibrutinib
T167301787294-07-8
Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib is an effective and orally active Bruton tyrosine kinase inhibitor (IC50: 1 nM). Remibrutinib has the potential for Chronic urticaria (CU) treatment.
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TargetMol | Inhibitor Hot
JAK3/BTK-IN-1
T98142674036-91-8In house
JAK3 BTk-in-1 is a dual JAK3 BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important targets in autoimmune diseases. JAK3 BTk-in-1 simultaneously inhibited the BTK JAK3 signaling pathway, showing a synergistic effect. JAK3 BTK-in-1 is a potential compound for the treatment of immune-related diseases, such as autoimmune diseases, certain types of cancer (including lymphoma and leukemia), and other diseases that may be characterized by an unbalanced immune response.
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6-8 weeks
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Avitinib
AC0010
T30241557267-42-1
Avitinib (AC0010), also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administration, avitinib covalently binds to and inhibits the activity of mutant forms of EGFR, including the drug-resistant T790M EGFR mutant, which prevents signaling mediated by mutant forms of EGFR. This may both induce cell death and inhibit tumor growth in EGFR-mutated tumor cells. EGFR, a receptor tyrosine kinase that is mutated in a variety of Ys, plays a key role in tumor cell proliferation and tumor vascularization. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR.
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BIIB068
T91921798787-27-5
BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd = 0.3 nM). BIIB068 is 400 times more selective for BTK than other kinases.
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Tirabrutinib hydrochloride
ONO-4059 (hydrochloride), GS-4059 (hydrochloride)
T123111439901-97-9
Tirabrutinib hydrochloride is a potent, highly selective, and irreversible oral BTK inhibitor. Tirabrutinib hydrochloride irreversibly covalently binds to Bruton tyrosine kinase (BTK) in B cells and exhibits potent in vitro cytotoxicity against many types of B cell malignancies, as well as in vivo antitumor activity in mouse models [1].
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(Rac)-PF-06250112
T126731609465-88-4
(Rac)-PF-06250112 is a racemic form of PF-06250112, a potent and highly selective BTK inhibitor that is orally bioavailable; it also inhibits BMX non-receptor tyrosine kinase and TEC [1].
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8-10 weeks
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AZ7550
T135641421373-99-0
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
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AZ7550 hydrochloride
AZ7550 hydrochloride (1421373-99-0 free base)
T13564L2309762-40-9
AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
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Spebrutinib besylate
CC-292 (besylate), AVL-292 (benzenesulfonate)
T143571360053-81-1
Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor with an IC50 of less than 0.5 nM and a Kinact Ki of 7.69×10^4 M^-1s^-1.
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1-2 weeks
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BMX-IN-1
BMX kinase inhibitor
T146921431525-23-3
BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton's tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.
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6-8 weeks
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CNX-774
CNX 774
T23021202759-32-7
CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).
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(R)-Pirtobrutinib
T358442101700-14-3
(R)-Pirtobrutinib ((R)-LOXO-305) is the less active enantiomer of Pirtobrutinib, a highly selective, non-covalent, next-generation BTK inhibitor that effectively inhibits diverse BTK C481 substitution mutations [1].
    7-10 days
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    Pirtobrutinib
    T362872101700-15-4
    Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to tumor regression in BTK-dependent lymphoma tumors in mouse xenograft models. Furthermore, Pirtobrutinib exhibits remarkable selectivity for BTK, with more than a 300-fold difference compared to 370 other kinases tested. Notably, at a concentration of 1 μM, Pirtobrutinib demonstrates no significant inhibition of non-kinase off-targets.
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    6-8 weeks
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    Luxeptinib
    T370851616428-23-9
    Luxeptinib (CG-806) is a novel pan-FLT3 pan-BTK inhibitor that is administered orally. It exhibits potent and reversible inhibition of these enzymes, acting through a non-covalent mechanism. Luxeptinib effectively induces cell cycle arrest, apoptosis, or autophagy in acute myeloid leukemia cells [1][2][3][4].
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    6-8 weeks
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    BMS-986143
    T391291643372-95-5
    BMS-986143, an orally active, reversible BTK inhibitor with an IC50 value of 0.26 nM, is designed for autoimmune disease research. Additionally, it targets TEC, BLK, BMX, TXK, FGR, YES1, and ITK, exhibiting IC50s of 3 nM, 5 nM, 7 nM, 10 nM, 15 nM, 19 nM, and 21 nM, respectively [1].
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    10-14 weeks
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    BAY 61-3606
    Syk inhibitor IV
    T4263732983-37-8
    BAY 61-3606 (Syk inhibitor IV) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
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    Branebrutinib
    BMS986195
    T54071912445-55-6
    Branebrutinib (BMS986195) is a potent, covalent inhibitor of Bruton's tyrosine kinase (BTK), >5,000-fold selective over all kinases outside of the Tec family (IC50 <1 nM for BTK).
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