13
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T14369 | AZD-0284 | ROR | |
AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1]. | |||
T4050 | GSK2981278 | ROR gama modulator 1 | ROR |
GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). | |||
T76775 | Fezakinumab | ILV 094 | Interleukin |
Fezakinumab is a potent monoclonal antibody to interleukin-22 (IL-22). Fezakinumab can be used to study immune system diseases and inflammation-related conditions such as psoriasis, rheumatoid arthritis and atopic dermat... | |||
T1955 | SB225002 | CXCR | |
SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2. | |||
T77174 | Efmarodocokin alfa | ||
Efmarodocokin alfa, a fusion protein combining human IL-22 with the IgG4 crystallizable fragment, activates IL-22 signaling. This compound has potential applications in the study of severe COVID-19 pneumonia [1]. | |||
T77173 | Eflepedocokin alfa | ||
Eflepedocokin alfa is a recombinant fusion protein that exhibits cell protective activity by comprising human IL-22 fused with the human IgG2-Fc domain. This compound activates the IL-22/IL-22R -mediated signal transduct... | |||
T40043 | RORγt Inverse agonist 10 | ||
RORγt Inverse agonist 10 is a highly potent and orally bioavailable compound that acts as an antagonist for the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt). With an IC50 of 51 nM, it effectivel... | |||
T76803 | Elsilimomab | ||
Elsilimomab (B-E8), an IgG1 monoclonal antibody targeting interleukin-6 (IL-6), exhibits a dissociation constant (K D) of 22 pM and an inhibitory concentration (IC 50) of 1.4 nM. It is applicable in researching multiple ... | |||
T79170 | Immuno modulator-1 | ||
Immuno modulator-1 (compound 22) effectively suppresses the secretion of TNFα and IL-2 in human peripheral blood mononuclear cells (hPBMC) with IC50 values of 4.7 nM and 26 nM, respectively. Additionally, this compound e... | |||
T36011 | P38 MAP Kinase Inhibitor IV | p38 MAPK Inhibitor IV | |
p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α an... | |||
T63559 | IRAK4-IN-22 | ||
IRAK4-IN-22 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 3 nM) and TAK1 (IC50: 17 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.10 μM. IRAK4-IN... | |||
T81678 | NF(N-Me)GA(N-Me)IL | Amylin (22-27) [NMeG24, NMeI26], human (IAPP) | |
NF(N-Me)GA(N-Me)IL is a biologically active peptide, representing a modified segment (amino acids 22 to 27) of the human islet amyloid polypeptide (hIAPP) sequence NFGAIL. This modification includes N-methylations at G24... | |||
T36629 | Givinostat | ||
Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF30... |