gx — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9647	GX 201	GX-201	Sodium Channel
	GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.		Sodium Channel
T27520	GX-395	GX 395
	GX-395 is a novel Nav1.7 inhibitor.
T27521	GX-936	GX 936,PF 05196233,PF05196233,GX936,PF-05196233
	GX-936, a Nav1.7 inhibitor, inhibits Nav1.7 through a voltage-sensor trapping mechanism, likely by stabilizing inactivated states of the channel.
T22829	GX-674		Sodium Channel
	GX-674 is a highly potent and selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 value of 0.1 nM measured at -40 mV for the study of inflammatory and neuropathic pain.		Sodium Channel
T69915	GX-585
	GX-585 is a novel potent inhibitor of NaV1.7 and highly selective against NaV1.5, having limited selectivity against NaV1.1 and NaV1.2.
T1439	Lacidipine	SN-305,GX-1048,GR-43659X	Apoptosis , Calcium Channel , Reactive Oxygen Species
	Lacidipine (SN-305) is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex tachycardia. It displays specifi...		Apoptosis , Calcium Channel , Reactive Oxygen Species
T80638	Glycinexylidide	GX	MEK
	Glycinexylidide (GX), the active metabolite of the local anesthetic Lidocaine, exhibits properties significant in inhibiting sodium channels with complex voltage dependence and mitigates the proliferation and spread of g...		MEK
T69914	Variegatic acid
	Variegatic acid is a natural inhibitor of β-hexosaminidase release and tumor necrosis factor (TNF)-α secretion from rat basophilic leukemia (RBL 2H3) cells, with IC50 values of 10.4 μM and 16.8 μM, respectively, also inh...
T5128	RGX-104 hydrochloride	SB742881,RGX-104 HCl	Liver X Receptor
	RGX-104 hydrochloride (SB742881) is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional activation of the ApoE gene.		Liver X Receptor
T7535	RGX-202	β-GPA,3-Guanidinopropionic Acid	AMPK , PPAR
	RGX-202 (β-GPA) is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK), activating PPARγ coac...		AMPK , PPAR
T2293	SGX-523		Raf , p38 MAPK , c-Met/HGFR , Bcr-Abl
	SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.		Raf , p38 MAPK , c-Met/HGFR , Bcr-Abl
T7768	RGX-104	RGX-104 free Acid	Liver X Receptor
	RGX-104 (RGX-104 free Acid) free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR)		Liver X Receptor
T2661	TGX-221	TGX221	PI3K
	TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.		PI3K
T10268	AGX51		Others
	AGX51 is an antagonist of inhibitor of DNA binding (ID) proteins. AGX51 treatment lead to pan-Id degradation, cell cycle arrest, and cell death.		Others
T24873	TGX-115	TGX 115	PI3K
	TGX-115 is a cell-permeable and potent inhibitor of the PI 3-K isoform p110β/p110δ (IC50 values of 0.13 μM for p110β and 0.63 μM for p110δ), an enzyme that regulates platelet adhesion and inhibits phosphoinositide (PI) 3...		PI3K
T1813	VGX-1027	VGX1027,VGX 1027,GIT 27	IL Receptor , TNF , Interleukin
	VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.		IL Receptor , TNF , Interleukin
T28168	NGX-267	AF-267B,AF267B,AF 267B,NGX 267
	NGX-267, a muscarinic M1 agonist, is used potentially for the treatment of Xerostomia, Alzheimer's disease and cognitive.
TP1531	Guangxitoxin 1E
	Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.
T78352	N-acetylglucosamine-1-P uridyltransferase (AGX1)	GlcNAc1pUT
	N-acetylglucosamine-1-P uridyltransferase (AGX1) (GlcNAc1pUT) is a bifunctional enzyme that couples with GlcNAc-1-P and UTP to catalyze the synthesis of UDP-GlcNAc through an uridyltransfer reaction. It exhibits acetyltr...
T79034	GXF-111		Epigenetic Reader Domain
	GXF-111, a proteolysis targeting chimera (PROTAC) molecule, efficiently induces the selective degradation of the BRD3 and BRD4-L proteins. It exhibits high binding affinities to both BRD3 BD1 and BRD3 BD2, with K i value...		Epigenetic Reader Domain