cd135 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2340	AC1NS4RE		Tyrosinase
	It is a tyrosine kinase inhibitor.		Tyrosinase
T1938	FLT3-IN-2		FLT
	FLT3-IN-2 is an FLT3 inhibitor (IC50<1 μM).		FLT
T4428	CCT241736		FLT , Aurora Kinase
	CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinica...		FLT , Aurora Kinase
T11298	FLT3-IN-3		FLT
	FLT3-IN-3 is an effective FLT3 inhibitor, and the IC50s of FLT3 WT and FLT3 D835Y are 13 and 8 nM, respectively.		FLT
T2272	BPR1J-097	BPR1J097	FLT
	BPR1J-097) is a novel FLT-3 inhibitor(IC50: 11±7 nM) with promising in vivo anti-tumor activities. It also inhibits FLT-3 D835Y (IC50: 3 nM).		FLT
T15335	FN-1501		FLT , CDK
	FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1501 also has anticancer activity.		FLT , CDK
T6756	AMG 925		FLT , CDK
	AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.		FLT , CDK
T6138	TCS 359	FLT3 Inhibitor	FLT
	TCS 359 (FLT3 Inhibitor) is a potent FLT3 inhibitor with IC50 of 42 nM.		FLT
T3065	TG101209		Apoptosis , FLT , c-RET , JAK , Autophagy
	TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.		Apoptosis , FLT , c-RET , JAK , Autophagy
T7673	ATH686	ATH 686	Apoptosis , FLT
	ATH686 is an potent and selective Inhibitor of FLT3.		Apoptosis , FLT
T9473	4SC-203		FLT
	4SC-203 is a multikinase inhibitor with potential antineoplastic activity. 4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated forms, and vascular endothelial growth factor receptors (VEG...		FLT
T6020	Pacritinib	SB1518	FLT , Tyrosine Kinases , JAK
	Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).		FLT , Tyrosine Kinases , JAK
T8317	5'-Fluoroindirubinoxime	5'-FIO	FLT
	5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).		FLT
TQ0235	AC710		FLT , PDGFR , c-Kit
	AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).		FLT , PDGFR , c-Kit
T6115	Fostamatinib	R788	FLT , Syk , Monoamine Transporter , Adenosine Receptor
	Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.		FLT , Syk , Monoamine Transporter , Adenosine Receptor
T16144	MRX-2843	UNC2371	Others , FLT
	MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3(IC50s of 1.3 nM and 0.64 nM, respectively).		Others , FLT
T2341	KW-2449	KW2449	Apoptosis , FGFR , FLT , JAK , Bcr-Abl , Src , c-Kit , Aurora Kinase
	KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.
T6350	CHIR-124	CHIR124,CHIR 124	Apoptosis , GSK-3 , FLT , Chk , PDGFR , Src
	CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.		Apoptosis , GSK-3 , FLT , Chk , PDGFR , Src
T2620	G-749	G749	Apoptosis , FLT , c-RET , TAM Receptor , Aurora Kinase
	G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants.		Apoptosis , FLT , c-RET , TAM Receptor , Aurora Kinase
T3455	Merestinib	LY2801653	Discoidin Domain Receptor (DDR) , FLT , c-Met/HGFR , ROS , ROS Kinase
	Merestinib (LY2801653) is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. Merestinib electively binds to c-Met, thereby inhibiting c-Met phosph...
T38562	AKN-028		FLT
	AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.		FLT
T2640	Rebastinib	DCC2036,DCC 2036,DCC-2036	Apoptosis , FLT , Bcr-Abl , Src
	DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT3, KDR, and Tie-2, and low activity to c-Kit. Re...		Apoptosis , FLT , Bcr-Abl , Src
T6174	R406	R-406 besylate	Apoptosis , FLT , Syk
	R406 (R-406 besylate) is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.		Apoptosis , FLT , Syk
T7007	UNC2025	mrx-6313,UNC-2025,UNC 2025	FLT , TAM Receptor
	UNC2025 (mrx-6313)(IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER/FLT3 inhibitor. UNC-2025 is about 20-fold selectivity higher than Axl and Tyro3.		FLT , TAM Receptor
T4409	Gilteritinib	ASP2215	FLT , TAM Receptor , c-Kit
	Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively). In preClinicalal studies, gilteritinib showed strong an...		FLT , TAM Receptor , c-Kit
T2638	Gandotinib	LY2784544	VEGFR , FGFR , FLT , JAK
	LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3.		VEGFR , FGFR , FLT , JAK
T2054	Altiratinib	DCC-2701	VEGFR , Tie-2 , FLT , Trk receptor , c-Met/HGFR
	Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with an HGF antagonist...		VEGFR , Tie-2 , FLT , Trk receptor , c-Met/HGFR
T1836	AZD2932		VEGFR , FLT , PDGFR , c-Kit
	AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit.		VEGFR , FLT , PDGFR , c-Kit
T0093L	Sorafenib	Bay 43-9006	Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy
	Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. Sorafenib has antitumor activity...
T2467	R406 free base	R406 (free base)	Apoptosis , FLT , Syk
	R406 free base (R406 (free base)) is a potent Syk inhibitor.		Apoptosis , FLT , Syk
T9027	CA-4948	Emavusertib	IRAK , FLT
	CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.		IRAK , FLT
T3068	AT9283	J-504568	Apoptosis , FLT , JAK , Bcr-Abl , Aurora Kinase , Autophagy
	AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).		Apoptosis , FLT , JAK , Bcr-Abl , Aurora Kinase , Autophagy
T41003	KG5		Raf , FLT , PDGFR , c-Kit
	KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 nM and 300 nM for PDGFRβ and PDGFRα. KG5 inhibits FLT3, KIT, and c-Raf with anticancer and antiangiogenic activities.		Raf , FLT , PDGFR , c-Kit
T2358	ENMD-2076		Apoptosis , VEGFR , FGFR , FLT , c-RET , PDGFR , Src , Aurora Kinase
	ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.
T2677	Crenolanib	ARO 002,CP-868596	FLT , PDGFR , Autophagy
	Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and FLT3 (IC50s: 11, 3.2, and 4 nM).		FLT , PDGFR , Autophagy
T8482	Ripretinib	DCC-2618	Apoptosis , VEGFR , FLT , PDGFR , c-Kit
	Ripretinib (DCC-2618) is an orally bioavailable inhibitor of KIT and PDGFRA.		Apoptosis , VEGFR , FLT , PDGFR , c-Kit
T4209	TAK-659 hydrochloride	TAK-659	VEGFR , FLT , Tyrosine Kinases , JAK , Syk
	TAK-659 hydrochloride (TAK-659) is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.		VEGFR , FLT , Tyrosine Kinases , JAK , Syk
T0093	Sorafenib tosylate	Bay 43-9006	Apoptosis , Raf , VEGFR , FLT , Ferroptosis , PDGFR , c-Kit , Autophagy
	Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
T2066	Quizartinib	AC220	Apoptosis , FLT , Autophagy , Ligands for Target Protein for PROTAC
	Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.
T2051	SKLB4771	FLT3-IN-1,FLT3-IN-1	FLT
	SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.		FLT
T4053	AST 487	NVP-AST 487	VEGFR , FLT , c-RET , Bcr-Abl , c-Kit
	AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.		VEGFR , FLT , c-RET , Bcr-Abl , c-Kit
T2516	Amuvatinib	MP470,HPK 56	Apoptosis , FLT , c-Met/HGFR , c-RET , DNA/RNA Synthesis , PDGFR , c-Kit
	Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.
T6711	Tyrphostin AG1296	Tyrphostin AG 1296,AG 1296	Apoptosis , FGFR , FLT , PDGFR , c-Kit
	Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.		Apoptosis , FGFR , FLT , PDGFR , c-Kit
T2605	Fostamatinib Disodium	Tamatinib Fosdium,R788(Disodium),R788 Disodium,R788 (Fostamatinib) Disodium	FLT , Syk
	Fostamatinib Disodium (R788 Disodium) is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.		FLT , Syk
T21503	(E/Z)-Zotiraciclib	(E/Z)-TG02,(E/Z)-SB1317	FLT , JAK , CDK
	(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.		FLT , JAK , CDK
T1667	Tandutinib	MLN518,CT53518,NSC726292	Apoptosis , FLT , CSF-1R , PDGFR , Src , c-Kit
	Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versu...		Apoptosis , FLT , CSF-1R , PDGFR , Src , c-Kit
T2586	Cabozantinib	XL184,BMS-907351	Apoptosis , VEGFR , FLT , c-Met/HGFR , c-RET , TAM Receptor , c-Kit
	Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM). Cabozantinib exhibits both antitumor and antiangiogenic activity...
T4349	Sitravatinib	MG516,MGCD516	Discoidin Domain Receptor (DDR) , VEGFR , FLT , Trk receptor , TAM Receptor , c-Kit , Ephrin Receptor
	Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl.
T6479	Dovitinib lactate hydrate	Dovitinib (TKI258) Lactate,Dovitinib Lactate,TKI258	VEGFR , FGFR , FLT , PDGFR , c-Kit
	Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) R...		VEGFR , FGFR , FLT , PDGFR , c-Kit
T2514	Linifanib	ABT-869,RG3635,AL-39324	Apoptosis , c-Fms , VEGFR , FLT , CSF-1R , PDGFR , c-Kit , Autophagy
	Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: 66 nM). Linifanib may exhibit potent antiprolife...

Compounds

AC1NS4RE

T2340

Target: FLT, Aurora Kinase

Synonym: FLT3 Inhibitor

Target: Apoptosis, FLT, c-RET, JAK, Autophagy

ATH686

T7673

Synonym: ATH 686

Target: Apoptosis, FLT

Target: FLT, Tyrosine Kinases, JAK

5'-Fluoroindirubinoxime

Target: FLT, PDGFR, c-Kit

Fostamatinib

T6115

Synonym: R788

Target: FLT, Syk, Monoamine Transporter, Adenosine Receptor

Target: Apoptosis, FGFR, FLT, JAK, Bcr-Abl, Src, c-Kit, Aurora Kinase

CHIR-124

T6350

Synonym: CHIR124,CHIR 124

Target: Apoptosis, GSK-3, FLT, Chk, PDGFR, Src

G-749

T2620

Synonym: G749

Target: Apoptosis, FLT, c-RET, TAM Receptor, Aurora Kinase

Merestinib

T3455

Synonym: LY2801653

Target: Discoidin Domain Receptor (DDR), FLT, c-Met/HGFR, ROS, ROS Kinase

Synonym: DCC2036,DCC 2036,DCC-2036

Target: Apoptosis, FLT, Bcr-Abl, Src

R406

T6174

Synonym: R-406 besylate

Target: Apoptosis, FLT, Syk

UNC2025

T7007

Synonym: mrx-6313,UNC-2025,UNC 2025

Target: FLT, TAM Receptor

Gilteritinib

T4409

Synonym: ASP2215

Target: FLT, TAM Receptor, c-Kit

Gandotinib

T2638

Synonym: LY2784544

Target: VEGFR, FGFR, FLT, JAK

Altiratinib

T2054

Synonym: DCC-2701

Target: VEGFR, Tie-2, FLT, Trk receptor, c-Met/HGFR

AZD2932

T1836

Synonym:

Target: VEGFR, FLT, PDGFR, c-Kit

Sorafenib

T0093L

Synonym: Bay 43-9006

Target: Apoptosis, Raf, VEGFR, FLT, Ferroptosis, PDGFR, c-Kit, Autophagy

R406 free base

T2467

Synonym: R406 (free base)

Target: Apoptosis, FLT, Syk

Target: Apoptosis, FLT, JAK, Bcr-Abl, Aurora Kinase, Autophagy

KG5

T41003

Synonym:

Target: Raf, FLT, PDGFR, c-Kit

ENMD-2076

T2358

Synonym:

Target: Apoptosis, VEGFR, FGFR, FLT, c-RET, PDGFR, Src, Aurora Kinase

Crenolanib

T2677

Synonym: ARO 002,CP-868596

Target: FLT, PDGFR, Autophagy

Ripretinib

T8482

Synonym: DCC-2618

Target: Apoptosis, VEGFR, FLT, PDGFR, c-Kit

TAK-659 hydrochloride

T4209

Synonym: TAK-659

Target: VEGFR, FLT, Tyrosine Kinases, JAK, Syk

Sorafenib tosylate

T0093

Synonym: Bay 43-9006

Target: Apoptosis, Raf, VEGFR, FLT, Ferroptosis, PDGFR, c-Kit, Autophagy

Quizartinib

T2066

Synonym: AC220

Target: Apoptosis, FLT, Autophagy, Ligands for Target Protein for PROTAC

SKLB4771

T2051

Synonym: FLT3-IN-1,FLT3-IN-1

Target: VEGFR, FLT, c-RET, Bcr-Abl, c-Kit

Amuvatinib

T2516

Synonym: MP470,HPK 56

Target: Apoptosis, FLT, c-Met/HGFR, c-RET, DNA/RNA Synthesis, PDGFR, c-Kit

Tyrphostin AG1296

T6711

Synonym: Tyrphostin AG 1296,AG 1296

Target: Apoptosis, FGFR, FLT, PDGFR, c-Kit

Fostamatinib Disodium

T2605

Synonym: Tamatinib Fosdium,R788(Disodium),R788 Disodium,R788 (Fostamatinib) Disodium

Target: FLT, Syk

(E/Z)-Zotiraciclib

T21503

Synonym: (E/Z)-TG02,(E/Z)-SB1317

Target: FLT, JAK, CDK

Tandutinib

T1667

Synonym: MLN518,CT53518,NSC726292

Target: Apoptosis, FLT, CSF-1R, PDGFR, Src, c-Kit

Cabozantinib

T2586

Synonym: XL184,BMS-907351

Target: Apoptosis, VEGFR, FLT, c-Met/HGFR, c-RET, TAM Receptor, c-Kit

Sitravatinib

T4349

Synonym: MG516,MGCD516

Target: Discoidin Domain Receptor (DDR), VEGFR, FLT, Trk receptor, TAM Receptor, c-Kit, Ephrin Receptor

Dovitinib lactate hydrate

T6479

Synonym: Dovitinib (TKI258) Lactate,Dovitinib Lactate,TKI258

Target: VEGFR, FGFR, FLT, PDGFR, c-Kit

Linifanib

T2514

Synonym: ABT-869,RG3635,AL-39324

Target: Apoptosis, c-Fms, VEGFR, FLT, CSF-1R, PDGFR, c-Kit, Autophagy

Cat No.	Product Name	Species	Expression System
TMPY-01247	FLT3 Protein, Human, Recombinant (T227M, His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th...
TMPK-00523	FLT3 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
	The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2 (fetal liver kinase) and Stk-1(stem cell tyrosine kinase) is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the re...
TMPK-00416	FLT3 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	CHO
	The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2 (fetal liver kinase) and Stk-1(stem cell tyrosine kinase) is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the re...
TMPY-05738	FLT3 Protein, Human, Recombinant (hFc)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th...
TMPY-06938	FLT3 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th...
TMPY-03704	FLT3 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th...

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Compounds

Recombinant Proteins