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Cat No. | Product Name | Synonyms | Targets |
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T10415 | Autotaxin-IN-3 | PDE | |
Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma. | |||
T22086 | HA 155 | Autotaxin Inhibitor IV | PDE |
HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine. | |||
T10418 | Autotaxin modulator 1 | PDE | |
Autotaxin modulator 1 is a new modulator of Autotaxin. | |||
T10416 | Autotaxin-IN-4 | PDE | |
Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis. | |||
T10417 | Autotaxin-IN-5 | PDE | |
Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis. | |||
T14352 | Autotaxin-IN-1 | PDE | |
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treatment of osteoarthritis pain[1]. | |||
T72837 | Autotaxin-IN-6 | ||
Autotaxin-IN-6 (compound 23) is a potent inhibitor of autotaxin (ATX), exhibiting an IC50 of 30 nM, and is capable of attenuating cell migration with potential applications in anticancer research [1]. | |||
T11533 | Z-HA155 | CS-963 | PDE |
Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM. | |||
T10545 | BIO-32546 | PDE | |
BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM. | |||
T2646 | HA130 | PDE | |
HA130 is a selective ATX (autotaxin) inhibitor. | |||
T31101 | CRT0273750 | CRT 0273750,CRT-0273750 | PDE |
CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM. | |||
T63190 | Cudetaxestat | BLD-0409 | PDE |
Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin. | |||
T4041 | Ziritaxestat | GLPG1690 | PDE |
Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients. | |||
T3631 | PF-8380 | PDE | |
PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhib... | |||
T38759 | ONO-8430506 | PDE | |
ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma. | |||
T10409 | ATX inhibitor 5 | PDE | |
ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50 : 15.3 nM) that reduces the level of CCl4-induced hepatic fibrosis and has anti-hepatic fibrosis effects,. | |||
T12372 | PAT-505 | EGFR | |
PAT-505 is an orally available, selective and potent inhibitor of autologous epidermal growth factor (IC50 2 nM in Hep3B cells, 9.7 nM in human blood, 62 nM in mouse plasma). | |||
T23293 | S32826 disodium | S 32826 | Others |
autotaxin inhibitor | |||
T28299 | PAT-078 | PAT078,PAT 078 | |
PAT-078 is an inhibitor of type II autotaxin. | |||
T39136 | ATX inhibitor 7 | ||
ATX inhibitor 7 is a autotaxin inhibitor and shows good oral exposure. | |||
T38488 | S32826 | ||
S32826 is a highly potent inhibitor of autotaxin, exhibiting an IC50 value of 8.8 nM. It displays comparable inhibitory properties towards various autotaxin isoforms, including α, β, and γ. Furthermore, S32826 effectivel... | |||
T28301 | PAT-494 | PAT 494,PAT494 | |
PAT-494 is an inhibitor of type II Autotaxin. | |||
T63612 | ATX inhibitor 8 | ||
ATX inhibitor 8 is an inhibitor of the autocrine motor factor Autotaxin (ATX). | |||
T16434 | PAT-048 | PDE | |
PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no effect on autotaxin protein and pulmonary lysophosphatidic ac... | |||
T63564 | ATX inhibitor 22 | ||
ATX inhibitor 22 is a novel inhibitor of ATX (autotaxin) (IC50: 218.9 μM) that lacks inhibitory activity against LPAR1. | |||
T36138 | BMP-22 | ||
BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM). It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid... | |||
T69647 | UCM-05194 | ||
UCM-05194 is a potent Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1). UCM-05194 Shows Efficacy in Neuropathic Pain Amelioration. UCM-05194 stands out as the most potent and selective LPA1 receptor agonist de... | |||
T14560 | BI-2545 | Others | |
BI-2545 is an autotaxin (ATX) inhibitor that significantly reduces LPA. For human ATX and rat ATX, the IC50s values are 2.2 nM and 3.4 nM , respectively. | |||
T70275 | PAT-347 | ||
PAT-347 is a potent Autotaxin Inhibitor. Autotaxin (ATX) is a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline. The ATX-LPA signali... | |||
T28300 | PAT-347 sodium | PAT-347,PAT347,PAT 347 | |
PAT-347 is a potent inhibitor of Autotaxin (ATX), a secreted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline. | |||
T63575 | PF-8380 hydrochloride | ||
PF-8380 hydrochloride is a powerful inhibitor of autotaxin, exhibiting an IC(50) of 2.8 nM in isolated enzyme assays and 101 nM in human whole blood. | |||
T64141 | ATX inhibitor 11 | ||
ATX inhibitor 11 is a potent inhibitor of ATX (autotaxin) (IC50: 2.7 nM). ATX inhibitor 11 alleviates the severity of fibrotic tissue and effectively reduces the deposition of α-SMA, a biomarker of fibrosis, in a mouse m... | |||
T81804 | MEY-003 | ||
MEY-003, an Autotaxin (ATX) inhibitor, exhibits EC50 values of 460 nM for hATX-β and 1.09 μM for hATX-ɣ (analysis with LPC18:1), demonstrating its potency against these isoforms. It acts non-competitively with a K i of 4... | |||
T61612 | ATX inhibitor 15 | ||
ATX inhibitor 15 (compound 30) is an indole-based carbamate derivative with a strong inhibitory effect on autotaxin (ATX), demonstrated by an IC50 of 2.17 nM. Additionally, ATX inhibitor 15 effectively inhibits ATX activ... | |||
T63325 | ATX inhibitor 9 | ||
ATX inhibitor 9 is a thickened heteroaryl derivative compound and a potent inhibitor of ATX. Among them Autotaxin (ATX), also known as ENPP2, is a secreted enzyme highly expressed mainly in lung cancer cells, bronchial e... | |||
T38000 | Lysosphingomyelin (d18:1) | ||
Sphingomyelins are complex membrane lipids composed of phosphorylcholine, sphingosine, and an acylated group, such as a fatty acid. Lysosphingomyelin is a naturally-occurring lipid which is produced by the removal of the... |
Cat No. | Product Name | Species | Expression System |
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TMPY-00463 | ENPP2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen... | |||
TMPY-02778 | ENPP2 Protein, Human, Recombinant (His) | Human | HEK293 |
ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen... | |||
TMPY-02055 | ENPP2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogen... |