3 ap

3-AP (Triapine) is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR).

3-AP-Me is the dimethyl derivative of the ribonucleotide reductase inhibitor 3-AP (SML0568). It activates the endoplasmic reticulum (ER) stress pathway by promoting eIF2α phosphorylation and upregulating gene expression of transcription factors ATF4 and ATF6, thereby inducing apoptosis. Additionally, 3-AP-Me activates cellular stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase, leading to the upregulation of spliced mRNA variant XBP1. It is applicable in cancer research.

AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.

L-AP3 is a potent antagonist of metabotropic glutamate receptor (mGluR), demonstrating inhibitory effects on D-phosphoserine and L-phosphoserine with IC50 values of 368 μM and 2087 μM, respectively.

20-O-Demethyl-AP3 is a secondary metabolite derived from Ansamitocin P-3 [a macrocyclic antitumor antibiotic] that exerts its therapeutic effects by inhibiting microtubules.

AP-C3 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII), with a pIC50 value of 6.3, and demonstrates only weak inhibition of cGKII-dependent anion secretion [1].

5Me3F4AP is an effective potassium channel blocker, with an IC50 ranging from 220 μM to 693 μM as the pH increases from 6.4 to 9.1. It has the potential to cross the blood-brain barrier and may be used in positron emission tomography (PET).

Ap3A is a vasoactive molecule that promotes the growth of vascular smooth muscle cells.

(Ala13)-Apelin-13 acetate, an APJ antagonist, modulates CRF-induced enhanced colonic motility, visceral sensation, and gut barrier.

3-Aminopropylphosphinic acid (3-APPA), a phosphonic analog of gamma-aminobutyric acid (GABA), acts as a potent and selective agonist of the GABA B receptor.

(R)-tert-Butyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate is a useful organic compound for research related to life sciences and the catalog number is T65597.

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine is a useful organic compound for research related to life sciences. The catalog number is T66986 and the CAS number is 767340-03-4.

1-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione is a useful organic compound for research related to life sciences. The catalog number is T67692 and the CAS number is 764667-65-4.

Metitepine is a serotonin receptor antagonist in the CNS used as an antipsychotic.

3-Acetylpyridine adenine dinucleotide functions as an alternative reductant in glutamate-synthase-catalyzed glutamate synthesis. 3-Acetylpyridine adenine dinucleotide demonstrates kinetic parameters in the AcPdADH-dependent reaction wherein Kcat and Km values for other substrates are reduced approximately fourfold relative to the NADH-dependent reaction. 3-Acetylpyridine adenine dinucleotide shows a Km of ~3 µM and acts as a competitive inhibitor of NADH in NADH-dependent glutamate synthesis with a Ki of 1 µM. 3-Acetylpyridine adenine dinucleotide provides meaningful mechanistic insights into redox cofactor selectivity in enzymatic glutamate biosynthesis.

Rhamnocitrin 3-apiosyl-(1→2)-glucoside is a natural product for research related to life sciences. The catalog number is TN6650 and the CAS number is 148031-68-9.

A3-APO is an antimicrobial peptide that exhibits significant antibacterial activity through a dual mechanism of action (membrane lysis and inhibition of intracellular targets). It can neutralize bacterial toxins and enhance the expression of anti-inflammatory cytokines (such as IL-4 and IL-10) without leading to resistance. A3-APO also accelerates wound healing in burn-infected mouse models of Acinetobacter baumannii and Staphylococcus aureus.

NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells. 3. Flavokawain A (Flavokavain A) may exert anti-inflammatory responses by suppressing LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.

CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM.

AP-C5 is a compound with selective inhibition of guanosine 3',5' cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII), with a Pic50 value of 7.2 for cGMP, and can be used in the study of diarrheal diseases.

1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (Nudifloric Acid) from Cordyceps bassiana targets to block AP-1-mediated luciferase activity, implying an anti-inflammatory function.

Farudodstat (ASLAN003) is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity, showing potential as a first-in-class candidate in AML [Acute Myeloid Leukemia].

DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.

T-5224 is a transcription factor c-Fos/AP-1 inhibitor that specifically inhibits the DNA-binding activity of c-Fos/c-Jun without affecting other transcription factors.