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(35)
By Target- Proteasome
- Apoptosis(13)
- Autophagy(11)
- Endogenous Metabolite(3)
- Antibiotic(2)
- DUB(2)
- NF-κB(2)
- PROTACs(2)
- Parasite(2)
- Others(12)
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Results for "
20s proteasome
" in TargetMol Product Catalog- Inhibitors & Agonists46
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PROTAC 20S proteasome subunit β5 degrader 2
T200540
PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader targeting the 20S proteasome subunit β5 (20Sproteasomesubunit β5), with a DC50 of 0.16 μM. It inhibits the proliferation of FaDu cancer cells, showcasing an IC50 of 0.23 μM. Additionally, PROTAC20Sproteasomesubunit β5 degrader 2 demonstrates antitumor activity in a mouse model.
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PROTAC 20S proteasome subunit β5 degrader 1
T200715
PROTAC 20S proteasome subunit β5 degrader 1 (compound 12f) serves as a targeted degrader of the 20S proteasome subunit β5, exhibiting a DC50 value of 0.11 μM in FaDu cells. This compound disrupts the cell cycle and promotes apoptosis (apoptosis), while inhibiting cell proliferation and migration in both FaDu and KM3/BTZ cells. It is applicable for research into resistance to Bortezomib in pharyngeal carcinoma and multiple myeloma.
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