14-α demethylase

Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 [CYP3A].

Tioconazole (Vagistat) is a synthetic imidazole derivative, inhibits cell wall synthesis by inhibiting the biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and promoting loss of essential intracellular elements.

Miconazole (R18134) is an imidazole antifungal agent used both topically and via intravenous infusion.

Econazole ((±)-Econazol) is an imidazole derivative that is commonly used as a topical antifungal agent.

Econazole nitrate (NSC-243115) (Spectazole) is an imidazole class antifungal medicine.

Clotrimazole (FB 5097), an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol.

Rifampicin (Rifamycin AMP) is a broad-spectrum antibiotic. Rifampicin has a strong antibacterial effect against Mycobacterium tuberculosis and is also effective against gram-positive and gram-negative bacteria and viruses.

Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.

Fluconazole (UK-49858) belongs to the triazole class of antifungal agents and is a CYP51 inhibitor (IC99 = 0.20–0.39 μg/mL against Candida albicans), possessing broad-spectrum antifungal activity, good oral absorption, and cell permeability. This compound is used for the treatment of various invasive fungal infections.

Terconazole (Terazol 7) is a synthetic triazole derivative structurally related to fluconazole, antifungal Terconazole seems to disrupt cell wall synthesis by inhibiting biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and promoting loss of essential intracellular elements. Terconazole is active against Candida sp.

Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad-spectrum imidazole derivative with antifungal activity. Likely inhibiting cytochrome P450-dependent demethylation of lanosterol, it prevents ergosterol synthesis, a crucial component of the fungal cell membrane. This disruption of membrane synthesis and integrity alters permeability, promotes loss of essential intracellular components, and inhibits fungal cell growth.

Azalanstat (RS 21607) is an orally available selective mammalian lanosterol 14-alpha-demethylase inhibitor with hypocholesterolemic activity that inhibits cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes, and hamster livers through inhibition of the cytochrome P450 enzyme, lanosterol 14 alpha demethylase.

Oxiconazole is a broad-spectrum imidazole antifungal agent with fungicidal activity against T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini, M. gypseum, C. albicans, and M. furfur. have fungicidal activity, inhibiting ergosterol biosynthesis and disrupting fungal cell membrane integrity by disrupting cytochrome P450 enzymes (lanosterol 14- α demethylase). It also inhibits DNA synthesis and suppresses intracellular ATP concentration.

Epoxiconazole (BAS-480F) is a 14-α demethylase inhibitor. It inhibits ergosterol synthesis and fungal cell wall formation.

(Z)-Lanoconazole is the Z configuration of Lanoconazole, used for investigating dermatophytosis and onychomycosis. It inhibits sterol 14-alpha demethylase, disrupting fungal membrane ergosterol biosynthesis. Lanoconazole is a potent, orally active imidazole antifungal agent with a broad spectrum of activity against fungi both in vitro and in vivo [1] [2].

Myclobutanil hydroxide is a 14-α demethylase inhibitor that inhibits ergosterol synthesis and fungal cell wall formation. It also weakly inhibits testosterone production.

Voriconazole-D3 is a deuterated compound of Voriconazole. Voriconazole (T0120) has a CAS number of 137234-62-9. Voriconazole (T0120) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.

Voriconazole (Standard) is a reference standard for research and analysis in studies involving Voriconazole. Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.

Voriconazole-D3 (Standard) is a reference standard of Voriconazole-D3 intended for quantitative analysis, quality control, and related biochemical research applications. Voriconazole-d3 is a deuterated compound of Voriconazole. Voriconazole has a CAS number of 137234-62-9. Voriconazole is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.