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Fibroblast Growth Factors, FGFs

Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by macrophages; FGF are involved in a wide variety of processes, most notably as crucial elements for normal development in animal cells. Any irregularities in their function lead to a range of developmental defects. These growth factors typically act as systemic or locally circulating molecules of extracellular origin that activate cell surface receptors. FGFs are multifunctional proteins with a wide variety of effects; they are most commonly mitogens but also have regulatory, morphological, and endocrine effects. A defining property of FGFs is that they bind to heparin and to heparan sulfate.

FGF-10 Protein, Human, Recombinant
TMPY-01061
Expression system: E. coli
Length: 38-208, Full Length of Mature Protein
Activity: Organoid Coculture、Cells
  • $236
In Stock
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SPR-compatible buffer
FGF-2 Protein, Human, Recombinant
TMPY-00749
Expression system: E. coli
Length: 143-288, Full Length of Mature Protein of Isoform 1
Activity: Organoid Coculture、Cells
  • $174
In Stock
Size
QTY
SPR-compatible buffer
FGF-8b Protein, Human, Recombinant
TMPY-06986
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning.
  • $297
In Stock
Size
QTY
SPR-compatible buffer
FGF-9 Protein, Human, Recombinant
TMPJ-00090
Expression system: E. coli
Length: 1-208, Full Length
Activity: Cell Activity
  • $92
In Stock
Size
QTY
FGF-4 Protein, Human, Recombinant
TMPY-05004
Expression system: E. coli
Length: 54-206, Partial
Activity: Cell Activity
  • $136
In Stock
Size
QTY
SPR-compatible buffer
FGF-2 Protein, Mouse, Recombinant
TMPJ-00037
Expression system: E. coli
Length: 1-154, Full Length
Activity: Cell Activity
  • $38
In Stock
Size
QTY
SPR-compatible buffer
FGF-1 Protein, Human, Recombinant
TMPY-00756
Expression system: E. coli
Length: 16-155, Full Length of Mature Protein
Activity: Cell Activity
  • $57
In Stock
Size
QTY
SPR-compatible buffer
FGF-17 Protein, Human, Recombinant
TMPY-03104
Expression system: E. coli
Length: 23-216, Full Length of Mature Protein
Activity: Cell Activity
  • $106
In Stock
Size
QTY
FGF-7/KGF Protein, Human, Recombinant (His)
TMPY-00403
Expression system: E. coli
Length: 32-194, Full Length of Mature Protein
Activity: Cell Activity
  • $106
In Stock
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QTY
FGF-9 Protein, Mouse, Recombinant (His)
TMPJ-01011
Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine and bovine FGF-9. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In the mouse embryo the location and timing of FGF-9 expression affects development of the skeleton, cerebellum, lungs, heart, vasculature, digestive tract, and testes .It may have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. Deletion of mouse FGF-9 is lethal at birth due to lung hypoplasia, and causes rhizomelia, or shortening of the proximal skeleton. An unusual constitutive dimerization of FGF 9 buries receptor interaction sites which lowers its activity, and increases heparin affinity which inhibits diffusion. A spontaneous mouse mutant, Eks, interferes with dimerization, resulting monomeric, diffusible FGF-9 that causes elbow and knee synostoses (joint fusions) due to FGF-9 misexpression in developing joints.
  • $82
In Stock
Size
QTY
FGF-18 Protein, Mouse, Recombinant (His)
TMPY-01415
FGF-18 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 22.5 kDa and the accession number is A0A7U3JW51.
  • $462
In Stock
Size
QTY
SPR-compatible buffer
FGF-9 Protein, Human, Recombinant (hFc)
TMPY-00804
Expression system: HEK293 Cells
Length: 4-208, Partial
Activity: Cell Activity
  • $136
In Stock
Size
QTY
SPR-compatible buffer
FGF-21 Protein, Human, Recombinant (Low Endotoxin)
TMPY-06935
FGF-21 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.55 kDa and the accession number is NP_061986.1.
  • $245
In Stock
Size
QTY
SPR-compatible buffer
FGF-8a Protein, Human, Recombinant
TMPY-00005
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning.
  • $296
In Stock
Size
QTY
FGF-21 Protein, Mouse, Recombinant (His)
TMPY-02139
Expression system: HEK293 Cells
Length: 1-210, Full Length
Activity: Not Tested
  • $306
In Stock
Size
QTY
SPR-compatible buffer
FGF-2 Protein, Chicken, Recombinant (His)
TMPH-00368
Expression system: P. pastoris (Yeast)
Length: 13-158, Full Length of Mature Protein
Activity: Not Tested
  • $256
In Stock
Size
QTY
Buffer-exchangeable
FGF-19 Protein, Human, Recombinant
TMPY-02907
FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglycans that function as coreceptors. It interacts with KL and KLB directly. However, it interacts with FGFR4 in the presence of heparin, KL or KLB. FGF19 is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1 2 cascades. It also stimulates glucose uptake in adipocytes.
  • $543
In Stock
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QTY
SPR-compatible buffer
FGF-2 Protein, Rat, Recombinant
TMPJ-00842
Expression system: E. coli
Length: 11-154, Partial
Activity: Cell Activity
  • $58
In Stock
Size
QTY
SPR-compatible buffer
FGF-18 Protein, Rat, Recombinant
TMPS-00030
FGF-18 Protein, Rat, Recombinant is expressed in E. coli. The accession number is O88182.
  • $138
In Stock
Size
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SPR-compatible buffer
FGF-1 Protein, Mouse, Rat, Recombinant
TMPY-01089
Expression system: E. coli
Length: 16-155, Full Length of Mature Protein
Activity: Cell Activity
  • $88
In Stock
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QTY
FGF-18 Protein, Human, Recombinant (His)
TMPY-02626
Expression system: HEK293 Cells
Length: 1-207, Full Length
Activity: ELISA
  • $197
In Stock
Size
QTY
SPR-compatible buffer
FGF-6 Protein, Human, Recombinant
TMPY-03382
FGF6, also known as FGF-6, belongs to the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF6 plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis. It is also required for normal muscle regeneration. FGF6 gene displayed oncogenic transforming activity when transfected into mammalian cells.
  • $106
In Stock
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SPR-compatible buffer
FGF-16 Protein, Human/Cynomolgus, Recombinant
TMPY-00117
Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart. FGF16 involvement in the fine tuning of the human skeleton of the hand. Impaired FGF16 function may also be responsible for connective tissue symptoms in MF4 patients. FGF16 expression is markedly increased in ovarian tumors, and FGF16 in conjunction with Wnt pathway contributes to the cancer phenotype of ovarian cells and suggests that modulation of its expression in ovarian cells might be a promising therapeutic strategy for the treatment of invasive ovarian cancers.
  • $141
In Stock
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FGF-7/KGF Protein, Human, Recombinant
TMPJ-00073
Expression system: E. coli
Length: 32-194, Full Length of Mature Protein
Activity: Organoid Coculture
  • $184
In Stock
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