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Natural Product Categories Natural Product Categories Pinopsida
Pinopsida represents the class of gymnosperms commonly known as conifers, including ecologically dominant trees such as pines, spruces, firs, and cedars. These plants are characterized by needle-like leaves, resin ducts, and strong adaptations to cold and nutrient-poor environments. Chemically, Pinopsida is rich in diterpenoids, resin acids, lignans, and essential oils, which function as defense compounds against pathogens and herbivores. In biomedical research, conifers are important sources of antimicrobial, anti-inflammatory, and anticancer compounds, with resin-derived molecules being widely studied for their pharmacological potential. Their evolutionary position as ancient seed plants also provides key insights into early gymnosperm metabolite biosynthesis and structural diversification of terpenoid pathways.
- PaclitaxelTaxol, NSC 125973T096833069-62-4Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
- $34
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Cited - (-)-Catechin(-)-Cianidanol, (-)-Catechuic acidT1359718829-70-4(-)-Catechin ((-)-Cianidanol), an isomer of catechin, inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.
- $40
SizeQTY - HomoharringtonineOmacetaxine mepesuccinate, Myelostat, HHT, CeflatoninT338026833-87-4Homoharringtonine (HHT) is a natural alkaloid that inhibits the translation of proteins and is cytotoxic. Homoharringtonine acts on the ribosomes of tumor cells to inhibit the elongation step of protein translation, thereby inhibiting protein synthesis, and has antitumor activity.
- $50
SizeQTY Cited - HarringtonineT828626833-85-2Harringtonine is a naturally occurring alkaloid that inhibits DNA synthesis and protein synthesis and strongly kills S-phase cells. Harringtonine has antitumor and antiviral activities.
- $37
SizeQTY - Piceatannoltrans-Piceatannol, AstringeninT061010083-24-6Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.
- $35
SizeQTY Cited - AmentoflavoneDidemethyl-ginkgetin, Amenthoflavone, 3',8''-BiapigeninT34171617-53-4Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the Delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having the dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted suppression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression.AntibacterialAntifungalApoptosisCOXCytochromes P450GABA ReceptorOpioid ReceptorPhospholipaseReactive Oxygen SpeciesROSRSV
- $30
SizeQTY Cited - GnetolT705286361-55-9Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly suppresses melanin biosynthesis in murine B16 melanoma cells. It is active in the inhibition of a
- $35
SizeQTY - TaxifolinDihydroquercetin, (+)-Taxifolin, (+)-DihydroquercetinT1738480-18-2Taxifolin (Dihydroquercetin) is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
- $30
SizeQTY Cited - IsorhapontigeninIsorhapotogeninT381432507-66-7Isorhapontigenin (Isorhapotogenin) is a tetrahydroxylated stilbenoid with a methoxy group. It is an isomer of rhapontigenin and an analog of resveratrol. It is found in the Chinese herb Gnetum cleistostachyum, in Gnetum parvifolium and in the seeds of the palm Aiphanes aculeata.
- $39
SizeQTY Cited - Dehydroabietic acidDehydroabietateTCS17721740-19-81. Dehydroabietic acid (Dehydroabietate) (DAA) is an EBV-EA activation inhibitor. 2. DAA is a useful food-derived compound for treating obesity-related diseases, by decreasing plasma glucose, insulin levels, plasma triglyceride (TG) , and hepatic TG levels. 3. DAA derivatives displays anti-secretory and anti-pepsin effect in animal models.
- $35
SizeQTY Cited - HinokiflavoneT4S018119202-36-9Hinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the formation of the B complex. Additionally, it acts as a SUMO protease inhibitor by impeding the activity of sentrin-specific protease 1 (SENP1). Hinokiflavone also demonstrates significant cytotoxicity, including the inhibition of MMP-9.
- $38
SizeQTY Cited - SecoisolariciresinolTN219729388-59-8Secoisolariciresinol is an enterolignan precursor, it has antioxidant, and estrogen-like activities, it can significantly suppress triglyceride (TG) accumulation in 3T3-L1 adipocytes.
- $129
SizeQTY - Baccatin IIIBaccatin ⅢT278827548-93-2Baccatin III (Baccatin Ⅲ) is a polycyclic diterpene which can be used for the semi-synthesis of paclitaxel and analogs. It has immunomodulatory and anticancer chemotherapeutic activities.
- $30
SizeQTY Cited - Calenduloside ESilphioside FTJS092826020-14-4Calenduloside E (Silphioside F) is a pentacyclic triterpene saponin extracted from Panax japonicus. It targets heat shock protein 90 (Hsp90) and has anti-apoptotic effect.AMPKApoptosisBcl-2 FamilyCalcium ChannelInterleukinJAKOthersPPARPyroptosisReactive Oxygen SpeciesROSSTATTNF
- $117
SizeQTY Cited - 9-dihydro-13-acetylbaccatin III9-DHAB III, 13-Acetyl-9-dihydrobaccatin IIIT5132142203-65-49-dihydro-13-acetylbaccatin III (9-DHAB III)is an apoptosis inducer. It shows cytotoxicity against the MCF7 cell line and drug-resistant cell line MCF7-ADR.
- $35
SizeQTY Cited - Podocarpusflavone ATQ013422136-74-9Podocarpusflavone A is a DNA topoisomerase I inhibitor with moderate anti-proliferative activity that induces cell apoptosis in MCF-7.
- $81
SizeQTY - Hinokitiolβ-thujaplicin, 4-IsopropyltropoloneT3717499-44-5Hinokitiol (4-Isopropyltropolone) can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein induced by the agent. Also, Hinokitiol modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells.
- $31
SizeQTY - Pinosylvin5-Styrylresorcinol, 3,5-stilbenediolT384322139-77-1Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.
- $38
SizeQTY - PruninNaringenin 7-0-glucosideTN2111529-55-5Prunin (Naringenin 7-0-glucoside) possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells; it also can stimulate growth of Pseudomonas aeruginosa and different Bacilllus sp. Prunin exhibits a markedly enhanced solubility compared to naringenin and naringin while maintaining the in vitro inhibition of HMG-CoA reductase.
- $116
SizeQTY - Pinobanksin 3-acetate3-O-AcetylpinobanksinTN296752117-69-8Pinobanksin 3-acetate (3-O-Acetylpinobanksin), a flavonoid derivative, is a strong antioxidant found in sunflowers and honey that inhibits LDL peroxidation.
- $68
SizeQTY - Caffeic acid 4-O-glucosideT125634166735-99-5Caffeic acid 4-O-glucoside (Linocaffein), a glycosylation product of Caffeic acid, reverses Aβ25-35-induced axonal atrophy and induces axonal regeneration in mouse cortical neurons, and can be used in Alzheimer's disease research.
- $393
SizeQTY - 7-Epi 10-desacetyl paclitaxel7-Epi-10-deacetyltaxol, 10-Deacetyl-7-epipaclitaxelT573878454-17-87-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.
- $37
SizeQTY - (+)-Catechin pentaacetateCatechin pentaacetateTN361016198-01-9(+)-Catechin pentaacetate (Catechin pentaacetate) is an esterified derivative of catechin with the potential to improve intestinal morphology and function and positively modulate the microbiome, and reduce iron and zinc transport proteins in the duodenum.
- $918
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