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Natural Product Categories Natural Product Categories Fagales
Fagales is an order of flowering plants that includes ecologically and economically important families such as Fagaceae (oaks, beeches), Betulaceae (birches), and Juglandaceae (walnuts). Members of Fagales produce a wide range of secondary metabolites including tannins, flavonoids, phenolic acids, and diarylheptanoids. In biomedical research, Fagales is highly significant due to its strong antioxidant, anti-inflammatory, anticancer, and metabolic regulatory properties, especially from tannin-rich species like oak and walnut. The order is also important in pharmacognosy and forestry science, linking wood chemistry with medicinal potential and ecological resilience.
- QuercetinSophoretinT2174117-39-5Quercetin, a flavonoid natural product, is a SIRT1 activator. It is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ with IC50 values of 2.4, 3.0, and 5.4 μM, respectively. Recognized as a heat shock protein inhibitor, Quercetin can significantly reduce exosome release in TII models by downregulating Hsp70 or Hsp90.
- $42
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Cited - beta-Amyroneβ-AmyronTN3500638-97-1beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM. beta-Amyrone has anti-inflammatory activity through inhibiting the expression of COX-2. beta-Amyrone exhibits anti-α-glucosidase inhibitory activity and moderate AChE activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity.
- $122
SizeQTY - DihydromyricetinAmpeloptin, AmpelopsinT299827200-12-0Dihydromyricetin (Ampelopsin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyricetin can activate autophagy by inhibiting mTOR signaling.
- $39
SizeQTY Cited - IsoquercetinQuercetin 3-o-glucopyranoside, Isoquercitrin, Hirsutrin, 3-GlucosylquercetinT5S0754482-35-91. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as a potential therapeutic agent against neurodegeneration in Parkinson's disease. 3. Isoquercetin is an inhibitor of Wnt/β-catenin and may be as a potential novel anti-tumoral agent, such as against human pancreati,liver cancer related to opioid receptors and to the activation of the mitogen-activated protein kinase (MAPK) signalling pathway. .
- $40
SizeQTY Cited - SanguisorbigeninUrsa-12,19-dien-28-oic acid, Tomentosolic acid, 3β-Hydroxyurs-12,19-dien-28-oic acid, 19-Dehydroursolic acidTN49436812-98-2Sanguisorbigenin (Tomentosolic acid) is a natural antimicrobial agent that inhibits methicillin-resistant Staphylococcus aureus (MRSA).
- $163
SizeQTY - NothofaginTN199611023-94-2In houseNothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases.
- $293
SizeQTY Cited - MyricetinCannabiscetinT0579529-44-2Myricetin (Cannabiscetin) is a natural flavonoid and MEK1 inhibitor. Myricetin has hypoglycemic, antioxidant, hepatoprotective, anti-tumor and anti-inflammatory activities.
- $30
SizeQTY Cited - QuercitrinXanthaurine, Sophoretin, Quercetin 3-rhamnoside, Meletin, 3-rhamnosyl quercetinT2871522-12-3Quercitrin (3-rhamnosyl quercetin) is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such as garden tomato (var. ), German camomile, endive, and kiwi, which makes quercitrin a potential biomarker for the consumption of these food products.
- $40
SizeQTY Cited - Ursolic acid acetateAcetylursolic acid, 3-Acetylursolic AcidT38197372-30-7Ursolic acid acetate (Acetylursolic acid) has cytotoxic activity, antimalarial activity, antitumor and anticancer activities. Acetylursolic acid has NO production inhibitory activities. Acetylursolic acid has inhibition against both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes.
- $64
SizeQTY Cited - Betulinic acidLupatic acid, Betulic acid, ALS-357T2830472-15-1Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretroviral, antimalarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase.AminopeptidaseApoptosisAutophagyEndogenous MetaboliteHIV ProteaseMitophagyNF-κBParasiteTopoisomerase
- $33
SizeQTY Cited - ProtopineMacleyine, Hypercorine, Fumarine, Corydinine, BiflorineT3429130-86-9Protopine (Fumarine) is a benzylisoquinoline alkaloid. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.
- $50
SizeQTY - EngeletinDihydrokaempferol 3-rhamnosideT6S0840572-31-61. Engeletin (Dihydrokaempferol 3-rhamnoside) may serve as a potential anti-inflammatory agent. 2. Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml. 3. Engeletin inhibits a recombinant human aldose reductase (IC5 value=1.16 microM).
- $41
SizeQTY Cited - BetulinTrochol, Betulol, betulinol, betulinic alcohol, betulineT3121473-98-3Betulin (betulinol) (lup-20(29)-ene-3β, 28-diol) is an abundant, naturally occurring triterpene. It is commonly isolated from the bark of birch trees where it forms up to 30% of the dry weight of the extractive and is found in birch sap as well.
- $33
SizeQTY Cited - Castanospermine1,6,7,8-Tetrahydroxyoctahydroindolizine, (1S,6S,7R,8R,8aR)-1,6,7,8-TetrahydroxyindolizidineTQ030879831-76-8Castanospermine (1,6,7,8-Tetrahydroxyoctahydroindolizine) is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.
- $32
SizeQTY Cited - Rotundic acidRutundic acidT5S050620137-37-5Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.
- $30
SizeQTY Cited - TrilobatinP-PhlorizinT2S07314192-90-9Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory response by suppressing the NF-κB signaling pathway.Trilobatin shows a strong inhibitory activity against α-glucosidase and a moderate inhibitory activity against α-amylase for management of postprandial hyperglycemia with less side effect.
- $48
SizeQTY - Myricetin 3-O-glucosideMyricetin 3-O-beta-D-glucopyranosideTN196119833-12-6Myricetin 3-O-glucoside (Myricetin 3-O-beta-D-glucopyranoside) is a flavonol extracted from Tibouchina paratropica, exhibiting anti-leishmania, anti-inflammatory, and antibacterial activities.
- $118
SizeQTY - Ilexoside DT2S0504109008-27-7Ilexoside D has ant-allergic, and anti-coagulant activities, it shows anti-tissue factor activity as well as the antithrombotic activity.
- $50
SizeQTY - Homovanillic acidVanillacetic acid, Vanilacetic acid, Homovaniuic acidT3S0507306-08-1Homovanillic acid (Vanillacetic acid), a dopamine metabolite, is linked to aromatic L-amino acid decarboxylase deficiency, growth hormone deficiency, celiac disease, and sepiapterin reductase deficiency.
- $40
SizeQTY - JugloneRegianin, 5-Hydroxy-1,4-naphthoquinoneT4010481-39-0Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.
- $41
SizeQTY Cited - Homogentisic acidMelanic acid, Homogentisinic Acid, 2,5-dihydroxyphenylacetic acidTCS2070451-13-81. Homogentisic acid (2,5-dihydroxyphenylacetic acid) shows interesting antioxidant and antiradical activities, and protective effect against thermal-cholesterol degradation, comparable to those of well known antioxidants. 2. Homogentisic acid is the primary precursor of melanin synthesis in Vibrio cholerae, a Hyphomonas strain, and Shewanella colwelliana. 3. A derivative of homogentisic acid which inhibits Pfnek-1 with an IC(5) around 1.8 muM, this product is moderately active in vitro against a FcB1 P. falciparum strain (IC(5) = 12 muM).
- $30
SizeQTY - Myricetin 3-O-galactosideMyricetin 3-O-beta-D-galactopyranosideTN196215648-86-9Myricetin 3-O-galactoside (Myricetin 3-O-beta-D-galactopyranoside) can inhibit xanthine oxidase (xanthine oxidase; XO) activity, lipid peroxidation and scavenging free radicals. Myricetin 3-O-galactoside has many effects, including cytotoxicity, anti-oxidation, anti-genotoxicity, anti-infectivity, anti-inflammatory and antioxidant activities, and its main effect is to inhibit the synthesis of inducible nitric oxide synthase (iNOS). The IC50 of Myricetin 3-O-galactoside inhibited lipid peroxidation was 160 μg/mL.
- $147
SizeQTY - Ilexgenin AT2S0501108524-94-3Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr
- $64
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