Biotin

Biotinyl tyramide, a biotin derivative, is used for tyramide signal amplification, as a reagent to amplify both in situ hybridization and immunohistochemical signals protocols.

Biotin-aniline is a probe that reacts strongly to RNA and DNA.Biotin-aniline is highly efficient and is used to capture subcellular transcriptomes in living cells with high spatial specificity.

Sulfo-NHS-SS-Biotin sodium (Sulfosuccinimidyl 3-[[2-(biotinamido)ethyl]dithio]propionate) is a cell-impermeant and long-chain cleavable amine-reactive biotinylation reagent. It can be used for the labeling and purifying of cell-surface protein.

Sulfo-NHS-LC-LC-Biotin (Biotin-XX-SSE) is used for efficient and irreversible biotin labeling of antibodies, proteins and any other macromolecules containing a primary amine group (-NH2), thus permitting the use of streptavidin or affinity couplings for the detection and isolation of proteins; since the negatively charged reagent does not penetrate the cellular membrane, it is only labeled on the cellular surface for labeling.

Coumarin hydrazine is a fluorophore containing an aromatic hydrazine moiety that serves as a fluorescent chemical probe for labeling intracellular protein- and lipid-bound carbonyls, and as a fluorescent sensor in living cells for the detection of carbonylated biomolecules produced following oxidative stress.

Amine-PEG3-Biotin can be used as a signal amplification label.

Biotin-PEG-Thiol (MW 2000) is a compound composed of biotin, polyethylene glycol and thiol, an active polymer that can be used to study nanomaterials.

Biotin-C5-Azide (DecarboxyBiotin-N3) is an azide derivative with a biotin tag attached.

Fluorescein Biotin is a biotin-substituting fluorescent dye that detects and quantifies biotin binding sites by fluorescence or absorbance.Fluorescein Biotin undergoes fluorescence quenching when bound to avidin or streptavidin.

Biotin-BMCC is a biotinylation reagent.

Biotin-NH-PSMA-617 is a biotinylated derivative of the small molecule PSMA-617, designed to target the prostate-specific membrane antigen (PSMA), prominently expressed on prostate tumor cells [1].

CCP-biotin peptide (non-cyclized) is a biotin-labeled linear form of cyclic citrullinated peptide (CCP), designed for the detection of anti-citrullinated protein antibodies (ACPAs), which may recognize its linear structure. This peptide corresponds to amino acids 447-467 of human filaggrin (UniProt ID: P20930) and includes Q447H, S449C, G459R, E460G, and S462C substitutions, with citrullination at arginine 455.

Biotin-4-Fluorescein is a molecular probe designed for the detection and quantitative measurement of (strepto)avidin.

Biotin-PEG-OH (MW 3400) is a polymer consisting of biotin and polyethylene glycol (PEG) units [1].

Biotin-PEG4-dialkoxydiphenylsilane-picolyl azide is a clickable, acid-cleavable biotin-picolyl azide designed as an enrichment handle for labeling cell surface glycoproteins [1].

Biotin (5-fluorescein) conjugate (N-(Fluorescein-5-carbamidoethyl)biotinamide) is a fluorescent biotin derivative known for its high efficiency in cell labeling. This conjugate is utilized in biomedical research to detect and localize target molecules. It is extensively used in immunofluorescence staining experiments to enhance sensitivity and specificity.

γ-(6-Aminohexyl)-ATP-biotin serves as a multifunctional dye with extensive applications across various fields. This compound is a critical tool in biological research, facilitating the observation and analysis of cell structures, tracking of biomolecules, evaluation of cell functions, differentiation of cell types, detection of biomolecules, examination of tissue pathology, and monitoring of microorganisms. Its usage extends beyond basic scientific research to include clinical diagnostics, textile dyeing, functional textile processing, food pigments, and dye-sensitized solar cells. This wide-reaching utility underscores the importance of dyes in both traditional and emerging industries.

Biotin-DADOO (TFA) serves as a versatile dye with extensive applications in both scientific and industrial fields. In biological experiments, dyes like this are crucial for observing and analyzing cell structures, tracking biomolecules, evaluating cell functionality, distinguishing between cell types, detecting biomolecules, examining tissue pathology, and monitoring microorganisms. Their usage spans from fundamental research to a broad spectrum of clinical diagnostics. Additionally, dyes play a significant role in traditional industries such as textile dyeing and are increasingly utilized in emerging sectors like functional textile processing, food pigments, and dye-sensitized solar cells.

Biotin-PEG-azide (MW 3400) is a biotinylated polyethylene glycol (PEG) derivative featuring an azide group. Biotin functions as an enzyme co-factor for protein labeling, while PEG, a hydrophilic and water-soluble polymer with low toxicity, enhances solubility. The azide group, a moderately good leaving group, undergoes Cu-catalyzed reactions with alkynes, improving biotin's target binding efficiency.

Biotin-PEG-Alk (MW 20000) is a biotin-labeled polyethylene glycol (PEG) derivative with a terminal alkyne group for efficient click chemistry applications. Biotin serves as an enzymatic cofactor, providing specific protein labeling, while the hydrophilic PEG moiety offers solubility and low toxicity. The alkyne functionality enables copper-catalyzed azide-alkyne cycloaddition (CuAAC), enhancing target binding through reaction with azide-modified molecules.

Biotin-16-dUTP is a fluorescent substitute of dTTP.

15(S)-Hete-biotin (15(S)-Hydroxyeicosatetraenoic acid-biotin) is a metabolite of arachidonic acid produced via the 15-lipoxygenase pathway. It is utilized in identifying proteins and/or receptors that bind with 15(S)-HETE.

Tris-NTA Biotin is a biotinylated version of tris-NTA. It serves as a probe capable of reversibly labeling proteins and cell surfaces.

Biotin-PEG3-benzophenone is a biotin-labeled benzophenone. Benzophenone serves as both an endogenous metabolite and a photosensitizer, implicated in DNA photodamage. It can lead to oxidation of nucleobases, formation of cyclobutane pyrimidine dimers, single-strand breaks, DNA-protein crosslinks, or abasic sites, potentially causing a variety of lesions in nucleosides, oligonucleotides, or DNA.