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Angiogenesis Filter
Angiogenesis Tyrosine Kinase/AdaptorsACK1
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Syk
Spleen tyrosine kinase (SYK) is an important non-receptor tyrosine kinase involved in regulating signaling pathways of various cellular processes. It is mainly expressed in hematopoietic cells and bone marrow cells and is essential for B cell development, maturation and antibody production, and is a key therapeutic target for autoimmune and allergic diseases.
Fostamatinib
T6115901119-35-5
Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
- $36
Size
QTY
Entospletinib
Cited
T61011229208-44-9
Entospletinib (GS-9973) (IC50= 7.7 nM)is a specific Syk inhibitor, which is orally bioavailable.
- $32
Size
QTY
CitedSyk-IN-3
T130451312534-69-2In house
Syk-IN-3 is a Syk inhibitor with potential anti-inflammatory and anticancer activity and can be used to study immune dysregulation.
- $397
Size
QTY
Fostamatinib Disodium
T26051025687-58-4
Fostamatinib Disodium (R788 Disodium) is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulatory activities.
- $39
Size
QTY
R406 Cited
T6174841290-81-1
R406 (R-406 besylate) is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.
- $40
Size
QTY
CitedPiceatannol Cited
T061010083-24-6
Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.
- $39
Size
QTY
CitedEllagic acid Cited
T0465476-66-4
Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor (IC50=40 nM; Ki=20 nM) with ATP-competitive properties. Ellagic acid is an antioxidant and also possesses antiproliferative activity.
- $44
Size
QTY
CitedURMC-099
T60571229582-33-5
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19 42 14 150 nM, for MLK1 MLK2 MLK3 DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
- $52
Size
QTY
TAK-659 hydrochloride
T42091952251-28-3
TAK-659 hydrochloride (TAK-659) is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.
- $33
Size
QTY
GSK1904529A Cited
T60031089283-49-7In house
GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
- $34
Size
QTY
CitedCevidoplenib dimesylate
T394372043659-93-2
Cevidoplenib dimesylate is an inhibitor of spleen tyrosine kinase (Syk), possessing anti-inflammatory and immunomodulating properties.
- $59
Size
QTY
Lanraplenib
T11824LL1800046-95-0
Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) being developed for treating inflammatory diseases. It inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.
- $47
Size
QTY
BAY 61-3606
T4263732983-37-8
BAY 61-3606 (Syk inhibitor IV) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
- $51
Size
QTY
Syk Inhibitor II dihydrochloride
T4391227449-73-2
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibit
- $132
Size
QTY
Cerdulatinib
T24871198300-79-6
Cerdulatinib (PRT2070) is an novel oral dual Syk JAK inhibitor.
- $37
Size
QTY
Gusacitinib
T143311425381-60-7
Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).
- $35
Size
QTY
Linocinnamarin
TN7075554-87-0
Linocinnamarin (3-[4-(beta-D-Glucopyranosyloxy)phenyl]acrylic acid methyl ester) is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen-stimulated degranulation by LN is mainly due to inactivation of Syk phospholipase Cgamma (PLCgamma) pathways.
- $148
Size
QTY
PRT-060318
T69571194961-19-7
PRT-060318 (P142-76) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.
- $35
Size
QTY
Cerdulatinib hydrochloride
T61041369761-01-2
Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM 6 nM 8 nM 0.5 nM and 32 nM for JAK1 JAK2 JAK3 TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.
- $31
Size
QTY
PRT062607 hydrochloride
T26961370261-97-4
PRT062607 hydrochloride (P505-15 Hydrochloride) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least 80-fold selectivity for Syk over other kinases.
- $55
Size
QTY
SRX3207
T224302254693-15-5
SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.
- $51
Size
QTY
MNS
T65941485-00-3
MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
- $43
Size
QTY
R406 free base
T2467841290-80-0
R406 free base (R406 (free base)) is a potent Syk inhibitor.
- $39
Size
QTY
R112
T3185575474-82-7
R112 is an ATP-competitive inhibitor of Syk kinase. Ki=6 nM,IC50=226 nM.
- $33
Size
QTY
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