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Angiogenesis Syk

Syk

Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene.
Cat No. product name
T6174 R406HOT R406 is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.
T2696 PRT062607 hydrochlorideHOT PRT062607 (BIIB-057) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least 80-fold selectivity for Syk over other kinases.
T16995 TAS05567 TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, ...
T6003 GSK1904529A GSK1904529A is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
T6957 PRT060318 PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.
T2487 Cerdulatinib Cerdulatinib is an novel oral dual Syk/JAK inhibitor.
T6101 Entospletinib Entospletinib (IC50= 7.7 nM)is a specific Syk inhibitor, which is orally bioavailable.
T6104 Cerdulatinib hydrochloride Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
T0465 Ellagic acid Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
T3185 (E)-Elafibranor R112 is an ATP-competitive inhibitor of Syk kinase.
T6776 BAY-61-3606 dihydrochloride BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM).
T2467 R406 free base R406 (free base) is a potent Syk inhibitor.
T6115 Fostamatinib Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
T16776 RO9021 RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).
T7035 ANTHRAQUINONE-2-CARBOXYLIC ACID Anthraquinone-2-carboxylic acid acts as a potent anti-inflammatory and antinociceptive component in vivo, thus contributing to the immune regulatory role of frui...
T4209 TAK-659 hydrochloride TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent ...
T4391 Syk Inhibitor II (hydrochloride) Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chai...
T4348 Syk Inhibitor II Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).
T4263 BAY 61-3606 BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effec...
TN1549 Damnacanthal Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its...
TN2103 PROCYANIDIN C1 Procyanidin C1 is a natural product, with anti-inflammatory effects, and induces apoptosis.
T11824LL Lanraplenib Lanraplenib is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib inhibits S...
T11824L Lanraplenib monosuccinate Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans....
T11824 Lanraplenib succinate Lanraplenib succinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lan...
T2605 R788 Disodium Fostamatinib Disodium is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.
R406 HOT
T6174CAS 841290-81-1
R406 is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.
PRT062607 hydrochloride HOT
T2696CAS 1370261-97-4
PRT062607 (BIIB-057) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least 80-fold selectivity for Syk over other kinases.
TAS05567
T16995CAS 1429038-15-2
TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, ...
GSK1904529A
T6003CAS 1089283-49-7
GSK1904529A is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
PRT060318
T6957CAS 1194961-19-7
PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.
Cerdulatinib
T2487CAS 1198300-79-6
Cerdulatinib is an novel oral dual Syk/JAK inhibitor.
Entospletinib
T6101CAS 1229208-44-9
Entospletinib (IC50= 7.7 nM)is a specific Syk inhibitor, which is orally bioavailable.
Cerdulatinib hydrochloride
T6104CAS 1369761-01-2
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
Ellagic acid
T0465CAS 476-66-4
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
(E)-Elafibranor
T3185CAS 575474-82-7
R112 is an ATP-competitive inhibitor of Syk kinase.
BAY-61-3606 dihydrochloride
T6776CAS 648903-57-5
BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM).
R406 free base
T2467CAS 841290-80-0
R406 (free base) is a potent Syk inhibitor.
Fostamatinib
T6115CAS 901119-35-5
Fostamatinib(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
RO9021
T16776CAS 1446790-62-0
RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).
ANTHRAQUINONE-2-CARBOXYLIC ACID
T7035CAS 117-78-2
Anthraquinone-2-carboxylic acid acts as a potent anti-inflammatory and antinociceptive component in vivo, thus contributing to the immune regulatory role of frui...
TAK-659 hydrochloride
T4209CAS 1952251-28-3
TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent ...
Syk Inhibitor II (hydrochloride)
T4391CAS 227449-73-2
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chai...
Syk Inhibitor II
T4348CAS 726695-51-8
Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).
BAY 61-3606
T4263CAS 732983-37-8
BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effec...
Damnacanthal
TN1549CAS 477-84-9
Damnacanthal possesses anti-cancer, immunomodulatory, antinociceptive and anti-inflammatory actions, it can treat or prevent hepatocellular carcinoma through its...
PROCYANIDIN C1
TN2103CAS 37064-30-5
Procyanidin C1 is a natural product, with anti-inflammatory effects, and induces apoptosis.
Lanraplenib
T11824LLCAS 1800046-95-0
Lanraplenib is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib inhibits S...
Lanraplenib monosuccinate
T11824LCAS 1800046-97-2
Lanraplenib monosuccinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans....
Lanraplenib succinate
T11824CAS 1800047-00-0
Lanraplenib succinate inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans. Lan...
R788 Disodium
T2605CAS 1025687-58-4
Fostamatinib Disodium is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.