T22767 |
ER 50891
|
187400-85-7
|
98%
|
|
ER-50891 is a potent retinoic acid receptor alpha (RARα) antagonist. er-50891 reduces the inhibitory effect of allosteric retinoic acid and restores osteoblast d...
|
T68104 |
Mofarotene
|
125533-88-2
|
98%
|
|
Mofarotene is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of tumors and resp...
|
T77499 |
MSU-42011
|
2456434-36-7
|
98%
|
|
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
|
T24240 |
K-8012
|
1346513-17-4
|
98%
|
|
K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.
|
T14912 |
CD3254
|
196961-43-0
|
98%
|
|
CD3254 a selective agonist of retinoid-X-receptor (RXR).
|
T14689 |
BMS493
|
215030-90-3
|
98%
|
|
BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR), inhibiting retinoic acid-induced differentiation. It can enhance nuclear corepressor intera...
|
T67921 |
Retinoic acid-d5
|
78996-15-3
|
98%
|
|
Retinoic acid-d5 is the deuterium-labeled form of Retinoic acid. Retinoic acid is a natural RAR receptor agonist with an IC50 of 14 nM for RARα/β/γ and a Kd of 1...
|
T14143 |
AGN 194310
|
229961-45-9
|
98%
|
|
AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].
|
T15825 |
LY 178002
|
107889-32-7
|
98%
|
|
LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of...
|
T17209 |
UVI 3003
|
847239-17-2
|
98%
|
|
UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respective...
|
T1093 |
Adapalene
|
106685-40-9
|
98%
|
|
Adapalene is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
|
TQ0064 |
Peretinoin
|
81485-25-8
|
98%
|
|
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
|
T14090 |
AC-55649
|
59662-49-6
|
98%
|
|
AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.
|
T11844 |
LG-100064
|
153559-46-7
|
98%
|
|
LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)
|
T21714 |
BMS453
|
166977-43-1
|
98%
|
|
BMS453, a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through t...
|
T1872 |
Fenretinide
|
65646-68-6
|
98%
|
|
Fenretinide is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.
|
T14911 |
CD2665
|
170355-78-9
|
98%
|
|
CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM.
|
T4371 |
CD437
|
125316-60-1
|
98%
|
|
CD437 is a specifc Retinoic Acid Receptor γ (RARγ) agonist.
|
T1611 |
Isotretinoin
|
4759-48-2
|
98%
|
|
Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and a...
|
T3955 |
AR7
|
80306-38-3
|
98%
|
|
AR7 is a retinoic acid receptor α (RARα) antagonist.
|