Retinoid Receptor

Retinoid receptors are nuclear receptors (a class of proteins) that bind to retinoids. When bound to a retinoid, they act as transcription factors, altering the expression of genes with corresponding response elements. Significant age-related declines in the levels of retinoid receptors in the forebrains of rats have been reversed by supplementation with the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which can restore neurogenesis. Subtypes include: Retinoic acid receptors (RARs), Retinoid X receptors (RXRs), RAR-related orphan receptors (RORs).

Cat. No.	Product name	CAS No.	Purity
T22767	ER 50891	187400-85-7	98%
T22767	ER-50891 is a potent retinoic acid receptor alpha (RARα) antagonist. er-50891 reduces the inhibitory effect of allosteric retinoic acid and restores osteoblast d...
T68104	Mofarotene	125533-88-2	98%
T68104	Mofarotene is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of tumors and resp...
T77499	MSU-42011	2456434-36-7	98%
T77499	MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and...
T24240	K-8012	1346513-17-4	98%
T24240	K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.
T14912	CD3254	196961-43-0	98%
T14912	CD3254 a selective agonist of retinoid-X-receptor (RXR).
T14689	BMS493	215030-90-3	98%
T14689	BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR), inhibiting retinoic acid-induced differentiation. It can enhance nuclear corepressor intera...
T67921	Retinoic acid-d5	78996-15-3	98%
T67921	Retinoic acid-d5 is the deuterium-labeled form of Retinoic acid. Retinoic acid is a natural RAR receptor agonist with an IC50 of 14 nM for RARα/β/γ and a Kd of 1...
T14143	AGN 194310	229961-45-9	98%
T14143	AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].
T15825	LY 178002	107889-32-7	98%
T15825	LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of...
T17209	UVI 3003	847239-17-2	98%
T17209	UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respective...
T1093	Adapalene	106685-40-9	98%
T1093	Adapalene is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
TQ0064	Peretinoin	81485-25-8	98%
TQ0064	Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
T14090	AC-55649	59662-49-6	98%
T14090	AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.
T11844	LG-100064	153559-46-7	98%
T11844	LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)
T21714	BMS453	166977-43-1	98%
T21714	BMS453, a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through t...
T1872	Fenretinide	65646-68-6	98%
T1872	Fenretinide is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.
T14911	CD2665	170355-78-9	98%
T14911	CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, the Kis are 110 nM and 306 nM.
T4371	CD437	125316-60-1	98%
T4371	CD437 is a specifc Retinoic Acid Receptor γ (RARγ) agonist.
T1611	Isotretinoin	4759-48-2	98%
T1611	Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and a...
T3955	AR7	80306-38-3	98%
T3955	AR7 is a retinoic acid receptor α (RARα) antagonist.