HIF/HIF Prolyl-Hydroxylase

HIF prolyl-hydroxylase is an enzyme involved in the HIF (Hypoxia-inducible factor) signalling pathways, and is the target for a set of therapeutic drugs called HIF prolyl-hydroxylase inhibitors. Hypoxia-inducible factor (HIF) is an evolutionarily conserved transcription factor that allows the cell to respond physiologically to low concentrations of oxygen. A class of prolyl hydroxylases which act specifically on HIF has been identified; hydroxylation of HIF allows the protein to be targeted for degradation.

Cat. No.	Product name	CAS No.	Purity
T3289	Amifostine	20537-88-6	98%
T3289	Amifostine anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
T9627	PHD-1-IN-1	2009343-14-8	98%
T9627	PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
T50099	HIF-2α-IN-4	882268-69-1	98%
T50099	HIF-2a translation inhibitor is a compound used as a molecular building block.
T1141	Fenbendazole	43210-67-9	98%
T1141	Fenbendazole is an antinematodal benzimidazole used in veterinary medicine.
T7802	M1001	874590-32-6	98%
T7802	M1001 is a HIF-2α agonist.
T3S2344	β,β-Dimethylacrylshikonin	24502-79-2	98%
T3S2344	1. Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combine...
T11589	Hydroxycitric acid tripotassium hydrate	6100-05-6	98%
T11589	Potassium citrate monohydrate effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydr...
T5176	Desidustat	1616690-16-4	98%
T5176	Desidustat is an inhibitor of HIF hydroxylase.
T29797	AKB-6899	1007377-55-0	98%
T29797	AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macr...
T21653	1,4-DPCA	331830-20-7	98%
T21653	1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HI...
T5537	IDF-11774	1429054-28-3	98%
T5537	IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
TL0001	Dencichine	5302-45-4	98%
TL0001	Dencichine is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation ...
T5684	Ethyl 3,4-dihydroxybenzoate	3943-89-3	98%
T5684	Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
T0256	Citric acid trilithium salt tetrahydrate	6080-58-6	98%
T0256	Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and me...
T67831	HIF-2α agonist 2	2750141-15-0	98%
T67831	HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
T1152	Albendazole	54965-21-8	98%
T1152	Albendazole is used as a drug indicated for the treatment of a variety of worm infestations.
T12675L	PT2399	1672662-14-4	98%
T12675L	PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50:...
T6823	E3330	136164-66-4	98%
T6823	E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
T7880	IOX4	1154097-71-8	98%
T7880	IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)
T2445	FG-2216	223387-75-5	98%
T2445	FG-2216 is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo induction...