Home Tools
Log in
Cart

HIF/HIF Prolyl-Hydroxylase

HIF prolyl-hydroxylase is an enzyme involved in the HIF (Hypoxia-inducible factor) signalling pathways, and is the target for a set of therapeutic drugs called HIF prolyl-hydroxylase inhibitors. Hypoxia-inducible factor (HIF) is an evolutionarily conserved transcription factor that allows the cell to respond physiologically to low concentrations of oxygen. A class of prolyl hydroxylases which act specifically on HIF has been identified; hydroxylation of HIF allows the protein to be targeted for degradation.
Cat. No. Product name CAS No. Purity Chemical Structure
T3289 Amifostine 20537-88-6 98%
Amifostine anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
T9627 PHD-1-IN-1 2009343-14-8 98%
PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
T50099 HIF-2α-IN-4 882268-69-1 98%
HIF-2a translation inhibitor is a compound used as a molecular building block.
T1141 Fenbendazole 43210-67-9 98%
Fenbendazole is an antinematodal benzimidazole used in veterinary medicine.
T7802 M1001 874590-32-6 98%
M1001 is a HIF-2α agonist.
T3S2344 β,β-Dimethylacrylshikonin 24502-79-2 98%
1. Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combine...
T11589 Hydroxycitric acid tripotassium hydrate 6100-05-6 98%
Potassium citrate monohydrate effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydr...
T5176 Desidustat 1616690-16-4 98%
Desidustat is an inhibitor of HIF hydroxylase.
T29797 AKB-6899 1007377-55-0 98%
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macr...
T21653 1,4-DPCA 331830-20-7 98%
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HI...
T5537 IDF-11774 1429054-28-3 98%
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
TL0001 Dencichine 5302-45-4 98%
Dencichine is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation ...
T5684 Ethyl 3,4-dihydroxybenzoate 3943-89-3 98%
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
T0256 Citric acid trilithium salt tetrahydrate 6080-58-6 98%
Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and me...
T67831 HIF-2α agonist 2 2750141-15-0 98%
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
T1152 Albendazole 54965-21-8 98%
Albendazole is used as a drug indicated for the treatment of a variety of worm infestations.
T12675L PT2399 1672662-14-4 98%
PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50:...
T6823 E3330 136164-66-4 98%
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
T7880 IOX4 1154097-71-8 98%
IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)
T2445 FG-2216 223387-75-5 98%
FG-2216 is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo induction...
Amifostine
T3289
Amifostine anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
PHD-1-IN-1
T9627
PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
HIF-2α-IN-4
T50099
HIF-2a translation inhibitor is a compound used as a molecular building block.
Fenbendazole
T1141
Fenbendazole is an antinematodal benzimidazole used in veterinary medicine.
M1001
T7802
M1001 is a HIF-2α agonist.
β,β-Dimethylacrylshikonin
T3S2344
1. Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combine...
Hydroxycitric acid tripotassium hydrate
T11589
Potassium citrate monohydrate effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydr...
Desidustat
T5176
Desidustat is an inhibitor of HIF hydroxylase.
AKB-6899
T29797
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macr...
1,4-DPCA
T21653
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HI...
IDF-11774
T5537
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
dencichine
TL0001
Dencichine is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation ...
Ethyl 3,4-dihydroxybenzoate
T5684
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
Citric acid trilithium salt tetrahydrate
T0256
Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and me...
HIF-2α agonist 2
T67831
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
Albendazole
T1152
Albendazole is used as a drug indicated for the treatment of a variety of worm infestations.
PT2399
T12675L
PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50:...
E3330
T6823
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
IOX4
T7880
IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)
FG-2216
T2445
FG-2216 is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo induction...
1 2 3