skeleton

Usnic Acid (Usniacin) is an antimicrobial, antitumor and enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Usnic acid induces necrosis in certain cells.

2-Ketoglutaric acid Sodium (AKG) is a key molecule in the TCA cycle. It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination reactions (mediated by branched-chain amino acid transaminases) in which glutamate is a common amino donor.

2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) and exhibits antioxidant activity. As an intermediate in the Krebs cycle, 2-Ketoglutaric acid can generate ATP or GTP. 2-Ketoglutaric acid also serves as the primary carbon skeleton for nitrogen assimilation reactions.

Batabulin (T138067) is an antitumor compound that binds covalently and selectively to a subset of the β-tubulin isotypes, disrupting microtubule polymerization. This disruption affects cell morphology, induces cell-cycle arrest, and ultimately leads to apoptotic cell death.

Bohemine is a cyclin-dependent kinase inhibitor.

Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1].

SMIFH2 is formin homology 2 (FH2) domains inhibitor.

Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.

MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).

Azadirachtin has antifungal activity, used as an insecticide.

2-Methyl-2H-indazole-3-carboxylic acid can be used as a potentially active molecular skeleton for the design and synthesis of biologically active compounds.

3-Aminophenol can provide an aromatic ring skeleton for the synthesis of various dyes and is also a core raw material for the synthesis of para-amino-salicylic acid.

Barbituric acid is a pyrimidine derivative and the basic skeleton of barbiturate drugs, commonly used in the preparation of barbiturate drugs and other heterocyclic compounds. It exhibits weak inhibitory activity against tyrosinase in mushrooms.

Adipic dihydrazide (ADH) is a dihydrazide with a symmetrical C4 skeleton, commonly used as a bifunctional cross-linking agent for water-in-oil emulsions and a curing agent for epoxy resins. ADH exhibits antibacterial activity against E. coli and P. aeruginosa.

Ursonic Acid (TOS-BB-0966) belongs to the family of Ursane Triterpenes whose structure is based on the pentacyclic ursane skeleton. It has potential as HIV-1 Protease Inhibitor.

Chelidamic acid is a heterocyclic organic acid with a pyran skeleton and acts as an inhibitor of glutamate decarboxylase, with a Ki of 33 μM.

Collagen, Type I, from bovine achilles tendon is a type I collagen derived from bovine achilles tendon, which is widely found in marine invertebrate tissues. Collagen, Type I, from bovine achilles tendon is the only component of collagen fibers that make up the dermis, and plays a major role in bone and connective tissue. connective tissues, and functions primarily by forming and maintaining the integrity of the skeleton.

Nortrachelogenin-8'-O-beta-glucoside is a lignan with a diarylhydroxybutyrolactone skeleton which isolated from the leaves and stems of Trachelospermum jasminoides (Lindl.) Lem.

(R,R)-(+)-Hydrobenzoin is an o-diol compound with chiral configuration, which belongs to endogenous metabolites and is often used as chiral ligand or chiral auxiliary reagent in asymmetric synthesis to induce stereoselectivity. (R,R)-(+)-Hydrobenzoin rigid diphenyl glycol skeleton can form complexes with metal ions, which has important application value in catalysis and chiral recognition research.

Deprodone propionate (RD20000) is a synthetic corticosteroid suitable for inflammation research.

3-Amino-5-bromo-2-methylpyridine (3ABMP) is a key reagent for constructing heterocyclic compounds in the field of biochemistry. its unique structure enables it to act as a core skeleton for synthesizing candidate drugs containing pyridine structures such as antibacterial and antiviral drugs.

CP-8668 is an orally active nonsteroidal progesterone receptor modulator with tetrahydrobenzoindolone skeleton.

Dihydroisoalantolactone is found in herbs and spices. Dihydroisoalantolactone is isolated from roots of Inula helenium (elecampane). This compound Aliphatic heteropolycyclic, belongs to the class of organic compounds known as eudesmanolides, secoeudesmano

3-[(2,6-Dichlorophenyl)methyl]-3H-purin-6-amine is a small molecule compound based on a purine skeleton. 3-[(2,6-Dichlorophenyl)methyl]-3H-purin-6-amine acts as an orally effective, non-competitive, selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP). Acting in the liver, it enhances insulin signal transduction and can be used in research on obesity-associated type 2 diabetes and insulin resistance.