scopolamine

Scopolamine is a high-affinity (nanomolar level) muscarinic receptor antagonist that can reversibly inhibit 5-HT₃ receptor responses (IC₅₀ = 2.09 μM). It is commonly used to induce animal models of Alzheimer's disease or memory impairment.

Scopolamine hydrobromide is a tropane alkaloid derived from the Solanaceae family. It is a high-affinity (nanomolar level) muscarinic receptor antagonist and can also reversibly inhibit 5-HT₃ receptor responses (IC₅₀ = 2.09 μM). It is commonly used to induce animal models of Alzheimer's disease or memory impairment.

Scopolamine butylbromide ((-)-Scopolamine butylbromide) is a competitive antagonist of mAChR (IC50: 55.3 ± 4.3 nM).

Norscopolamine is a natural product

Anisodamine (6-beta-Hydroxyhyoscyamine) is an antagonist of muscarinic and nicotinic cholinoceptor with similar affinities at the muscarinic receptor as scopolamine and atropine. Anisodamine improve the microcirculation in states of shock and can be used in studies about organophosphate poisoning.

Tropine is a secondary metabolite of the Solanaceae family of plants and is an anticholinergic reagent. It is a common intermediate used in the synthesis of various biologically active alkaloids (e.g. hyoscyamine, scopolamine).

Littorine is a tropane alkaloid found in a variety of plants including Datura and Atropa belladonna. It is closely related in chemical structure to atropine, hyoscyamine, and scopolamine, which all share a common biosynthetic pathway.

Tenuifoliside B is a natural product from the roots of Polygala tenuifolia.And is a target lactate dehydrogenase inhibitor. Tenuifoliside B has cognitive improving and cerebral protective effects. it can inhibit potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment in mice.

Suffruticosol A, a neuroprotective compound isolated from the seeds of P. lactiflora [1], mitigates scopolamine-induced neurodegenerative cellular damage and improves hippocampal cholinergic function. Additionally, it partially boosts BDNF signaling and has neuromodulatory effects, leading to the restoration of memory and cognitive performance in a scopolamine-induced mouse model.

Eurystatin B is an inhibitor of prolyl endopeptidase (PED). It exhibits protective effects in the scopolamine-induced amnesia process in rats.

Ingenol-3,4,5,20-diacetonide, a natural product isolated from the sap of the Euphorbia plant, exhibits a wide range of biological activities, including anti-tumor, anti-inflammatory, and immunomodulatory effects.

Soyasaponin Ba may represent viable candidates for effective vaccine adjuvants due to their higher and lower or non-haemolytic effects.Soyasaponins Ab and Bb prevent scopolamine-induced memory impairment in mice without the inhibition of acetylcholinester

Vitisin A ((+)-Vitisin A) is a resveratrol tetramer that can be isolated from the roots of Vitis vinifera and possesses antioxidant, anticancer, antiapoptotic, neuroprotective, and anti-inflammatory activities.It ameliorates the impaired learning and memory functions of scopolamine-induced amnesia in ICR mice, and can be used in the study of degenerative diseases.

Anisodamine hydrochloride, an anticholinergic and α1 adrenergic receptor antagonist, is used for enhancing blood flow in circulatory disorders like septic shock. It exhibits a range of pharmacological effects similar to Atropine and Scopolamine, including the inhibition of salivation, gastrointestinal and sweat secretion, gastrointestinal motility, respiratory secretion, and urinary bladder contraction in vivo [1].