paq

PAQ is a neuroprotective agent. It protects dopaminergic neurons from cell death without inhibiting glial cell proliferation in a rat midbrain culture model of Parkinson's disease when used at a concentration of 10 μM. PAQ (25 or 50 mg/kg, twice per day) prevents loss of dopaminergic neurons in the substantia nigra in a mouse model of Parkinson's disease induced by MPTP.

Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor with potential anti-inflammatory activity. It mitigates statin-induced toxicity in human skeletal muscle cells and protects guinea pigs from simvastatin-induced myotoxicity, useful for research on hypercholesterolemia and HMG-CoA reductase deficiency.

Lapaquistat is a cholesterol biosynthesis inhibitor and is the active metabolite of TAK-475. Lapaquistat can reduce statin-induced myotoxicity in lipid-lowering therapy.

Propaquizafop, a phenoxyisopropionic acid derivative, is used as a herbicide.

Leiocarpaquinone is a bioactive chemical from root of Uentilago leiocarpa Benth. (Rhamnaceae).

L-Topaquinone is a metabolite of dopaquione, an important intermediate in melanogenesis.

Paquinimod (ABR 25757) is a S100A9 inhibitor preventing S100A9 binding to TLR-4.

Iodixanol (Visipaque) is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography.

Sodium diatrizoate is an iodinated radiopaque X-ray contrast agent used as a diagnostic aid in angiography, urography, and radiography. It induces mitochondrial renewal and oxidative stress through calcium dysregulation and activates apoptosis.

Diatrizoate meglumine (Renocal) is the meglumine salt of diatrizoate, it is an organic, iodinated, radiopaque X-ray contrast medium used in diagnostic radiography.

Disopyramide (Triombrin) is a class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.

Metrizamide is a nonionic radiopaque contrast agent.

6-Hydroxydopa-quinone-CoA (6-Hydroxydopa quinone-coenzyme A) is a derivative of coenzyme A.