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Search Result

Search Results for " p97 "

Targets

p97 JAK

23

Compounds

5

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T4657 WHI-P97 JAK
WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane ...
T4657L WHI-P97 HCl 211555-05-4(free base) JAK
WHI-P97 HCl is a potent and selective JAK-3 inhibitor. WHI-P97 had an estimated Ki value of 0.09 microM from modeling studies and a measured IC50 value of 2.5 microM in EGFR kinase inhibition assays. WHI-P97 effectively ...
T40255 VCP/p97 inhibitor-1 VCP/p97 inhibitor-1
VCP/p97 inhibitor-1, a highly effective compound, inhibits VCP/p97 (also known as Cdc48, CDC-48, or Ter94) with an IC 50 of 54.7 nM. This inhibitor induces a disruption in protein homeostasis and interferes with the degr...
T3535 ML240 p97
ML240 is a selective, ATP-competitive p97 inhibitor.
T9008 NPD8733 Others
NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. It specifically binds to valosin-containing protein (VCP)/p97.
T1853 NMS-873 p97
NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.
T6796 CB-5083 CB5083,CB 5083 p97
CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).
T1969 DBEQ JRF 12 Apoptosis , p97 , Autophagy
DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.
T4684 ML241 hydrochloride p97
ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 may be a novel agent for the chemo...
T12236 NMS-859 ZINC169324353 Others
NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
T60193 CB-5339 p97
p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].
T27240 Eeyarestatin I Apoptosis
Eeyarestatin I is an inhibitor that inhibits the degradation and translocation of ER-associated proteins. Eeyarestatin I is associated with the p97 deubiquitination process and inhibits atx3 deubiquitination. Eeyarestati...
T22592 ATPγS tetralithium salt ATP-gamma-S tetralithium salt PERK
ATPγS tetralithium salt is a substrate for nucleotide hydrolysis and RNA unraveling activity of the eukaryotic translation initiation factor eIF4A, associated with p97 mutants and prions.
T6594 MNS Syk , Src , p97
MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.
T29068 UPCDC-30245 UPCDC 30245
UPCDC30245 is an AAA ATPase p97 allosteric inhibitor.
T34661 SMDC818909 SMDC 818909,SMDC-818909
SMDC818909 is an effective and selective p97 inhibitor.
T23616 ACJI-99C ACJI 99 C,ACJI-99-C,ACJI99C
ACJI-99C is a cell-permeable irreversible Cdc48/p97 inhibitor.
T69681 LC-1310
LC-1310 is an irreversible p97 inhibitor.
T3164 ML241 p97
ML241 is a potent and selective inhibitors of p97 ATPase.
T62148 NW 1028
NW 1028 is a potent inhibitor of VCP/p97. NW 1028 selectively acts on the ND1L domain of p97 and inhibits the degradation of p97-dependent reporter genes. NW 1028 has a regulatory effect on the mitotic spindle.
T69679 LC-1028
LC-1028 is a novel potent selective, covalent and irreversible inhibitor of p97 (valosin-containing protein) with IC50 =33 nM.
T79255 UPCDC30766 p97
UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].
T12114 MSC1094308 p97
MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase.

Recombinant Proteins

Species：
Human (5)
Expression System：
E. coli (4)
HEK293 (1)
Tag：
N-terminal 6xHis-tagged (2)
C-6His (1)
C-terminal hFc-tagged (1)
N-6His (1)
Cat No. Product Name Species Expression System
TMPJ-01013 VCP Protein, Human, Recombinant (His) Human E. coli
Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxi...
TMPJ-01120 KPNB1 Protein, Human, Recombinant (His) Human E. coli
Importin subunit beta-1(KPNB1) is a member of the importin beta family. KPNB1 contains 1 importin N-terminal domain and 19 HEAT repeats. It is involved in nucleocytoplasmic transport, a signal- and energy-dependent proce...
TMPH-01260 AMFR Protein, Human, Recombinant (hFc) Human HEK293
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-01259 AMFR Protein, Human, Recombinant (His) Human E. coli
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VC...
TMPH-01270 TRAIP Protein, Human, Recombinant (His) Human E. coli
E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethe...
Cat No. Product Name
L8600 Ubiquitination Compound Library

214 compounds
A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening；

Libraries

Ubiquitination Compound Library
L8600
Compounds: 214
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