or 611

Entacapone is a potent and specific peripheral catechol-O-methyltransferase (COMT) inhibitor with an IC50 of 151 nM. Entacapone is also a potential obesity-related gene (FTO) inhibitor that can inhibit FTO demethylation activity and be used in the study of metabolic diseases.

RGW 611, a morpholine derivative, enhances radiation effects and induces cell death in hypoxic V79-379A cells.

CRBN ligand-611 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of cereblon proteins. This compound can be linked to a target protein ligand via a linker to form a PROTAC.

TRI-611 is an oral, blood-brain barrier-penetrating ALK molecular chaperone degrader. TRI-611 specifically binds to E3 ligases, recruits and marks oncogenic ALK fusion proteins, and mediates their selective degradation via the ubiquitin-proteasome system. TRI-611 induces tumor regression in xenograft models of ALK-positive NSCLC. TRI-611 is equally effective in TKI-resistant tumor models. TRI-611 is suitable for use in studies of ALK-positive non-small cell lung cancer and TKI-resistant tumors.

T-611, a cytomegalovirus replication inhibitor, is used potentially for the treatment of cytomegalovirus infections.

MS611 is a BET bromine domain inhibitor that shows high selectivity only for BD in the BRD4 bromine domain.

NK 611 is a new semisynthetic analogue of etoposide and has been found to be more potent against several cancer cell lines in vitro than etoposide.

AL-611 is an HCV NS5B polymerase inhibitor (EC50 = 5 nM).

HPR-611 is a potent inhibitor of anaphylactic chemical mediator release.

NK-611 free acid is a new semisynthetic analogue of etoposide, which presumably also acts through inhibition of topoisomerase II, and has been found to be more potent against several cancer cell lines in vitro than etoposide.

Naftopidil (KT-611) (INN, marketed under the brand name Flivas), an antihypertensive medicine, is used as a selective α1-adrenergic receptor antagonist or α-blocker.

Bromhexine-D3 hydrochloride is a deuterated compound of Bromhexine Hydrochloride (T0828). Bromhexine hydrochloride has a CAS number of 611-75-6. Bromhexine hydrochloride is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.