nitrate

NOS-IN-1 (2-Imino-4-methylpiperidine acetate) is a potent and orally active inhibitor of NO synthase (NOS) isoforms. NOS-IN-1 exhibits IC50s of 0.1 μM, 0.2 μM, and 1.1μM for human iNOS (hiNOS), hnNOS and heNOS, respectively.

Naphazoline nitrate is an α1-Adrenergic receptor agonist. It also induces autophagy and necrotic cell death in erythroleukemia cells and inhibits erythroid differentiation. It used to treat congestion and ocular pathologies.

(4-Acetamidocyclohexyl) nitrate (BM121307) is an activator of guanylate cyclase.

Cycloguanil-D6 Nitrate is a dihydrofolate reductase inhibitor, deuterium-labeled Cycloguanil Nitrate (T69591).

Ald-Ph-amido-C2-nitrate (Example XXIVb) is a thiazolidine derivative mainly used as a noncleavable ADC linker[1].

Isosorbide-2-nitrate, a nitric oxide (NO) donor and active metabolite of isosorbide dinitrate, inhibits contraction in rabbit aortic strips induced by potassium chloride or angiotensin II and reduces vasopressin-induced coronary spasm in isolated rabbit hearts at concentrations of 100 and 1,000 µM.

Propatyl nitrate is a coronary vasodilator and a nitric oxide donor. It can be used for the study of cardiovascular and cerebrovascular conditions, such as acute angina pectoris.

Methylatropine is an antagonist of muscarinic acetylcholine receptors (IC50= <0.1 nM in a radioligand binding assay using isolated porcine brain membranes) and a derivative of atropine .1,2It reduces acetylcholine-induced decreases in blood pressure in rats when administered intravenously with an ED50value of 5.5 μg/kg.2Methylatropine reduces salivation, induces mydriasis, and increases heart rate in dogs.3 1.Schmeller, T., Sporer, F., Sauerwein, M., et al.Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptorsPharmazie50(7)493-495(1995) 2.Brezenoff, H.E., Xiao, Y.-F., and Vargas, H.A comparison of the central and peripheral antimuscarinic effects of atropine and methylatropine injected systemically and into the cerebral ventriclesLife Sci.42(8)905-911(1988) 3.Albanus, L.Central and peripheral effects of anticholinergic compoundsActa Pharmacol. Toxicol. (Copenh)28(4)305-326(1970)

Tetrahydrozoline (Tetryzoline) nitrate is a derivative of imidazoline. It is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline is widely used for the nasal congestion and conjunctival congestion research [1] [2].

Ethyl 3-guanidino-4-methylbenzoate nitrate is a useful organic compound for research related to life sciences. The catalog number is T66321 and the CAS number is 641569-96-2.

PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also upregulates the expression of the tumor suppressor retinoic acid receptor-beta 2 (RAR-beta2).

Cycloguanil nitrate is a dihydrofolate reductase inhibitor and is a metabolite of the antimalarial drug proguanil.

Sildenafil nitrate is a selective inhibitor of PDE5 (type 5 cGMP phosphodiesterase) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP).

Nitrate Reductase (cytochrome), Escherichia coli (EC 1.9.6.1), is an enzyme classified as a ferrocytochrome:nitrate oxidoreductase. This enzyme facilitates the reaction where ferrocytochrome, H+, and nitrate are converted into ferrocytochrome and nitrite.

Nitrate Reductase, Corn (EC 1.7.1.1), is an iron-sulfur molybdenum flavoprotein that catalyzes the reduction of nitrate to nitrite.

Nitrate Reductase from Aspergillus species (EC 1.7.1.2) is an iron-sulfur molybdenum flavoprotein that catalyzes the conversion of nitrite to nitrate.

Iron(III) nitrate nonahydrate, for cell culture (Ferric nitrate nonahydrate, for cell culture), is a compound suitable for use in cell culture applications.

Miconazole nitrate (R18134 nitrate), an imidazole antifungal agent, selectively affects the integrity of fungal cell membranes, high in ergosterol content and different in composition from mammalian cells membranes.

Econazole nitrate (NSC-243115) (Spectazole) is an imidazole class antifungal medicine.

Pilocarpine nitrate (Pilagan) is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.

Thiamine nitrate (Vitamin B1 nitrate) is an essential vitamin, and can enhance normal neuronal actives.

Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate (RS 35887) interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition. Butoconazole nitrate is active against many dermatophytes and yeasts. It also contains antibacterial effects against some gram-positive organisms.

Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris.

Fenticonazole Nitrate (Lomexin) is an azole agent with antifungal activity.