nitrate

Miconazole nitrate (R18134 nitrate), an imidazole antifungal agent, selectively affects the integrity of fungal cell membranes, high in ergosterol content and different in composition from mammalian cells membranes.

Econazole nitrate (NSC-243115) (Spectazole) is an imidazole class antifungal medicine.

Pilocarpine nitrate (Pilagan) is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.

Thiamine nitrate (Vitamin B1 nitrate) is an essential vitamin, and can enhance normal neuronal actives.

Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate (RS 35887) interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition. Butoconazole nitrate is active against many dermatophytes and yeasts. It also contains antibacterial effects against some gram-positive organisms.

Fenticonazole Nitrate (Lomexin) is an azole agent with antifungal activity.

Isoconazole nitrate (Fazol) (Travogen) is an azole antifungal reagent.

Naphazoline nitrate is an α1-Adrenergic receptor agonist. It also induces autophagy and necrotic cell death in erythroleukemia cells and inhibits erythroid differentiation. It used to treat congestion and ocular pathologies.

(4-Acetamidocyclohexyl) nitrate (BM121307) is an activator of guanylate cyclase.

Cycloguanil D6 Nitrate is a dihydrofolate reductase inhibitor, deuterium-labeled Cycloguanil.

Sanguinarine nitrate is a useful organic compound for research related to life sciences and the catalog number is T124812.

Sempervirine nitrate is an alkaloid extracted from Gelsemium elegans Benth., inhibiting HCC tumor growth and enhancing sorafenib's antitumor effects in vivo. It inhibits HCC proliferation and induces apoptosis by modulating the Wnt β-catenin pathway.

Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad-spectrum imidazole derivative with antifungal activity. Likely inhibiting cytochrome P450-dependent demethylation of lanosterol, it prevents ergosterol synthesis, a crucial component of the fungal cell membrane. This disruption of membrane synthesis and integrity alters permeability, promotes loss of essential intracellular components, and inhibits fungal cell growth.

Ald-Ph-amido-C2-nitrate (Example XXIVb) is a thiazolidine derivative mainly used as a noncleavable ADC linker[1].

1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially attributed to DHC. 2. Dehydrocorydal

Carnosine nitrate is a dipeptide molecule. It is highly concentrated in muscle and brain tissues.

Homoanserine Nitrate is a dipeptide found in mammalian brains and muscles.

Methylatropine is an antagonist of muscarinic acetylcholine receptors (IC50= <0.1 nM in a radioligand binding assay using isolated porcine brain membranes) and a derivative of atropine .1,2It reduces acetylcholine-induced decreases in blood pressure in rats when administered intravenously with an ED50value of 5.5 μg/kg.2Methylatropine reduces salivation, induces mydriasis, and increases heart rate in dogs.3 1.Schmeller, T., Sporer, F., Sauerwein, M., et al.Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptorsPharmazie50(7)493-495(1995) 2.Brezenoff, H.E., Xiao, Y.-F., and Vargas, H.A comparison of the central and peripheral antimuscarinic effects of atropine and methylatropine injected systemically and into the cerebral ventriclesLife Sci.42(8)905-911(1988) 3.Albanus, L.Central and peripheral effects of anticholinergic compoundsActa Pharmacol. Toxicol. (Copenh)28(4)305-326(1970)

L-Anserine nitrate (L-Anserine nitrate salt) is a dipeptide found in most animal tissues. In model systems it is a potent Antioxidant and scavener of hydroxyl radicals. The compound inhibits nonenzymatic protein glycation induced by aldose and ketose reducing sugars. It is much less potent than L-carnosine as an inhibitor of protein crosslinking.

Tetrahydrozoline (Tetryzoline) nitrate is a derivative of imidazoline. It is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline is widely used for the nasal congestion and conjunctival congestion research [1] [2].

Ethyl 3-guanidino-4-methylbenzoate nitrate is a useful organic compound for research related to life sciences. The catalog number is T66321 and the CAS number is 641569-96-2.

Sertaconazole nitrate (FI-7045), a topical broad-spectrum antifungal, is developed to supply an additional agent for the treatment of superficial cutaneous and mucosal infections.

PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also upregulates the expression of the tumor suppressor retinoic acid receptor-beta 2 (RAR-beta2).

Cycloguanil nitrate is a dihydrofolate reductase inhibitor and is a metabolite of the antimalarial drug proguanil.