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Results for "

mnk

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    21
    TargetMol | Inhibitors_Agonists
  • Natural Products
    1
    TargetMol | Natural_Products
  • Recombinant Protein
    9
    TargetMol | Recombinant_Protein
MNK/PIM-IN-1
T400922430792-91-7
MNK/PIM-IN-1 is a novel dual inhibitor targeting both MNK and PIM pathways, characterized by its favorable pharmacokinetic profile.
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mnk inhibitor 9
T727521889336-59-7
MNK Inhibitor 9 is a potent, selective inhibitor of MNK1 2, demonstrating IC50 values of 0.003 µM for both MNK1 and MNK2. It exhibits good cell permeability, making it suitable for tumor-related research.
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8-10 weeks
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MNK1/2-IN-5
T607331426928-20-2
MNK1 2-IN-5 is a potent and selective MNK1 2 inhibitor with anticancer activity and can be used to study solid tumors and hematological malignancies.
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6-8 weeks
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MNK
3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione
T99452055078-49-2
MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1].
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TargetMol | Inhibitor Sale
MNK1/2-IN-7
T869182548283-27-6
MNK1 2-IN-7 (compound 20j) serves as an orally administered inhibitor targeting MNK1 2, known for its anticancer properties and hERG safety. It also blocks the phosphorylation of eIF4E, thereby disrupting the MNK eIF4E signaling pathway and reducing cancer cell growth. Additionally, MNK1 2-IN-7 synergizes effectively with Ibrutinib. [15] [1]
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10-14 weeks
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mnk1/2-in-6
T62686
MNK1 2-IN-6 is a potent and selective inhibitor of MNK1 (IC50: 2.3 nM) and MNK2 (IC50: 3.4 nM) that induces apoptosis in a concentration-dependent manner.
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10-14 weeks
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MNK1/2-IN-8
T880212430793-35-2
MNK1 2-IN-8 (compound 15b) serves as an inhibitor of MNK1 2, exhibiting potent IC 50 values of 0.8 nM for Mnk1 and 1.5 nM for Mnk2. Additionally, this compound demonstrates anti-proliferative effects and induces cell cycle arrest.
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10-14 weeks
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HSN748
T2043962409925-53-5
HSN748 is an analog of ponatinib and acts as a multi-kinase inhibitor. It exhibits inhibitory activity against kinases such as FLT3, ABL1, RET, PDGFRα β, MNK1, and MNK2. HSN748 can suppress the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines, making it a useful compound in leukemia research.
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10-14 weeks
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DS12881479
T606812373065-59-7
DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].
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6-8 weeks
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TargetMol | Inhibitor Sale
QL-X-138
T389601469988-63-3In house
QL-X-138 is a potent and selective BTK and MNK dual kinase inhibitor that binds covalently to BTK and non-covalently to MNK. The IC50 values of QL-X-138 are 9.4 nM for BTK, 107.4 nM for MNK1, 26 nM for MNK2, and 3.5 μM against Dengue 2. QL-X-138 is used in the study of B-cell malignancies and B-cell malignant tumors.
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6-8 weeks
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QL-X-138 HCl
QL-X-138 HCl(1469988-63-3 Free base)
T38960L In house
QL-X-138 HCl is a novel selective and highly potent BTK MNK dual-kinase inhibitor with anticancer activity that binds covalently to BTK and noncovalently to MNK. QL-X-138 HCl inhibited BTK, MNK1, and MNK2 kinases. QL-X-138 HCl has anti-dengue virus 2 activity and shows anti-proliferative activity in acute myeloid leukemia cells. QL-X-138 HCl can be used to study lymphoma and leukemia.
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Tomivosertib
eFT508
T34681849590-01-7
Tomivosertib (eFT508) is a potent and highly selective MNK1 and MNK2 inhibitor with an IC50 value of 1-2 nM.
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MK2-IN-3 hydrate
MK-2 Inhibitor III
T120581186648-22-5
MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)
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TargetMol | Inhibitor Sale
ETC-206
T152501464151-33-4
ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).
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TargetMol | Inhibitor Sale
SLV-2436
SEL201-88, SLV 2436, SEL-201
T44242095704-43-9
SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8 5.4 nM).
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CGP 57380
MNK1 Inhibitor
T6440522629-08-9
CGP 57380 (MNK1 Inhibitor) is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases.
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EB1
T7358242951-68-8
EB1 is a potent and selective MNK kinase inhibitor with inhibitory effects on MNK1 and MNK2 with IC50 values of 0.69 μM and 9.4 μM, respectively.EB1 inhibits the growth of cancer cells, promotes apoptosis, and inhibits the phosphorylation of eIF4E.
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6-8 weeks
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AZ7550
T135641421373-99-0
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
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Cercosporamide
(-)-Cercosporamide
T10764131436-22-1
Cercosporamide is a ATP-competitive Pkc1 kinase inhibitor (IC50 <50 nM; Ki <7 nM). It also is a unique Mnk inhibitor.
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6-8 weeks
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HG-10-102-01
T71961351758-81-0
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
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TargetMol | Inhibitor Sale
ETC-168
T863851464150-99-9
ETC-168 is a selective, orally active MNK inhibitor with IC50 values of 23 nM for MNK1 and 43 nM for MNK2. It demonstrates antiproliferative efficacy both in vivo and in vitro [1].
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4-6 weeks
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