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Results for "

low cytotoxicity

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    145
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    2
    TargetMol | Peptide_Products
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    1
    TargetMol | Inhibitory_Antibodies
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    TargetMol | Recombinant_Protein
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    TargetMol | Inhibitors_Agonists
MKK7-COV-9
T608572283355-59-7In house
MKK7-COV-9 is a selective and potent covalent inhibitor of MKK7 with inhibitory effects on MKK7-induced protein-protein interactions.MKK7-COV-9 interrupts the activation of primary B-cells in response to LPS.MKK7-COV-9 shows low cytotoxicity at high concentrations.
  • Inquiry Price
6-8 weeks
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SARS-CoV-2 Mpro-IN-9
SARS-CoV-2 Mpro IN 9, SARS-CoV-2 Mpro-IN 9
T794552754370-99-3In house
SARS-CoV-2 Mpro-IN-9 (compound c7), a nonpeptidic, noncovalent inhibitor of SARS-CoV-2 main protease (Mpro), exhibits potent inhibitory action (IC50 = 0.085 μM) and improved physicochemical and drug metabolism and pharmacokinetics (DMPK) properties. It effectively suppresses viral replication in SARS-CoV-2-infected Vero E6 cells (EC50 = 1.10 μM) and demonstrates low cytotoxicity (CC50 > 50 μM) [1].
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6-8 weeks
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Antimicrobial agent-22
THI 6c
T794682373339-51-4In house
Antimicrobial agent-22 (THI 6c) is a broad-spectrum, multi-target antibacterial with rapid bactericidal efficacy, effective anti-biofilm activity, and low cytotoxicity and hemolytic properties [1].
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6-8 weeks
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Bictegravir Sodium
GS-9883 Sodium
T353401807988-02-8
Bictegravir Sodium (GS-9883 Sodium) is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir Sodium exhibits potent and selective anti-HIV activity and low cytotoxicity
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DODAP
T38679127512-29-2
DODAP is an ionic cationic lipid with low cytotoxicity and high transfection efficiency that can be used to synthesize liposomes and encapsulate biologically active molecules such as mRNA, siRNA and plasmid DNA.
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7-10 days
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Bz-RS-ISer(3-Ph)-Ome
Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate
T705532981-85-4
Bz-RS-ISer(3-Ph)-Ome (Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate) is a paclitaxel derivative that inhibits the HSV replication cycle at low cytotoxicity, blocks mitosis in Vero cells, affects the size of M-MSV-induced tumors, and influences the immune response by inhibiting PHA-induced proliferation of T lymphocytes.
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TargetMol | Inhibitor Sale
Antimalarial agent 14
4-hydroxy-3-phenyl-naphthalene-1,2-dione, 2-Hydroxy-3-phenyl-1,4-naphthoquinone
T223811150-59-0
Antimalarial agent 14 (NSC-102533) is a bioactive chemical.
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TargetMol | Inhibitor Sale
Cathepsin X-IN-1
T608122418577-51-0
Cathepsin X-IN-1 (compound 25) is a potent Cathepsin X inhibitor (IC50 = 7.13 μM) that reduces PC-3 cell migration with low cytotoxicity [1].
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6-8 weeks
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TargetMol | Inhibitor Sale
YYA-021
YYA 021
T6256144217-65-2
YYA-021 inhibits HIV entry, with high anti-HIV activity and low cytotoxicity.
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TargetMol | Inhibitor Sale
Tau-aggregation and neuroinflammation-IN-1
T628992175953-98-5
Tau-aggregation and neuroinflammation-IN-1 is a potent inhibitor of tau protein aggregates, showing significant inhibitory activity against AcPHF6 and full-length tau protein aggregates. It has anti-inflammatory activity, reduces NO release, exhibits low cytotoxicity against LSP-stimulated BV2 cells, and reverses okadaic acid-induced memory impairment in rats.
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6-8 weeks
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TargetMol | Inhibitor Sale
Enpp/Carbonic anhydrase-IN-2
T776312883495-39-2
Enpp Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp Carbonic anhydrase-IN-2 induced apoptosis.Enpp Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells.
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TargetMol | Inhibitor Sale
Liquiritigenin-7-apiosylglucoside
Liquiritigenin-7-O-β-D-glucopyranosyl-(1→2)-β-D-apiofuranoside
T13756135432-48-3
Liquiritigenin-7-O-β-D-glucopyranosyl-(1→2)-β-D-apiofuranoside, a flavonoid extracted from Glycyrrhiza roots, exhibits low cytotoxicity on a variety of tumor and normal cells.
    7-10 days
    Inquiry
    Rilematovir
    JNJ-53718678, JNJ-678
    T156211383450-81-4
    Rilematovir (JNJ-678) is an inhibitor of fusion protein with antiviral activity and low cytotoxicity. Rilematovir can be used in studies about respiratory syncytial virus treatment.
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    7-10 days
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    MMG-11
    T16123313254-94-3
    MMG-11 inhibits both TLR2 1 and TLR2 6 signaling (IC50s: 1.7 μM for Pam3CSK4-induced hTLR2 1 and 5.7 μM for Pam2CSK4-induced hTLR2 6 responses). MMG-11 is an effective and selective human TLR2 antagonist with low cytotoxicity.
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    7-10 days
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    ATP-polyamine-biotin
    T174541800401-93-7
    ATP-polyamine-biotin is a cell-permeable, efficient kinase cosubstrate with conversions and kinetics similar to those of other known ATP analogues. APB shows a cytotoxicity EC50 value of 19 ± 1 mM. ATP-polyamine-biotin is shown to promote biotin labeling
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    LpxC-IN-14
    T200428
    LpxC-IN-14 (compound 6i) is an effective inhibitor of LpxC, exhibiting antibacterial activity and low cytotoxicity. It also demonstrates an acceptable plasma protein binding rate.
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    SARS-CoV-2-IN-97
    T200450364338-71-6
    SARS-CoV-2-IN-97 (Compound CO-01) is an inhibitor of the SARS-CoV-2Nsp15 endoribonuclease, exhibiting an IC50 of 53.5 μM. It demonstrates low cytotoxicity in A549-AT cells with an IC50 value of 134 μM.
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    2-4 weeks
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    HIV-1 protease-IN-14
    T200601
    HIV-1protease-IN-14 (compound 5ae) is an effective inhibitor of HIV-1protease, exhibiting Ki values of 0.28 nM and 56.9 nM against WTHIV-1PR and R41THIV-1PR, respectively. This compound also demonstrates low cytotoxicity.
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    SARS-CoV-2-IN-96
    T200648
    SARS-CoV-2-IN-96 (compound 12b) acts as an inhibitor for both HCoV-OC43 (EC50= 97 nM) and SARS-CoV-2 (EC50= 45 nM), while displaying low cytotoxicity in Huh7 cells (CC50=10 μM).
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    PS-166276
    T201008348089-57-6
    PS-166276 is a potent p38 inhibitor with low cytotoxicity. It exhibits an IC50 value of 28 nM against p38 kinase and an IC50 of 170 nM in the THP-1 TNFα assay.
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    6-8 weeks
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    MDG506
    MDG 506, MDG-506
    T202892933005-54-0
    MDG506 is a novel selective androgen receptor (AR) interaction disruptor that demonstrates low cytotoxicity in prostate cancer (PCa) models and shows a dose-dependent reduction in prostate-specific antigen expression induced by classical antiandrogens.
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    TXY541
    T2030891499168-63-6
    TXY541 is an orally active antibacterial agent that is converted into PC190723 under physiological conditions. It demonstrates strong antibacterial activity against Staphylococcus aureus and exhibits low cytotoxicity towards mammalian cells.
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    hDHODH-IN-16
    T203173
    hDHODH-IN-16 (Compound 3t) is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 0.11 μM. It demonstrates very low cytotoxicity towards healthy HaCaT cells, with an IC50 value exceeding 200 μM.
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    HIV-1 inhibitor-79
    T203329
    HIV-1inhibitor-79 (Compound 3k) is an HIV inhibitor that demonstrates significant inhibitory activity against HIV-1 and its common mutants, with IC50 values of 1.9 nM for HIV-1, K103, 8.7 nM for L100I, and 11 nM for E138K. It exhibits low cytotoxicity and a high selectivity index (CC50 = 21.95 μM, SI = 11478). Additionally, HIV-1inhibitor-79 shows antiviral activity against HIV-2, with an EC50 value of 6.14 μM, and effectively inhibits HIV-1 reverse transcriptase with an IC50 of 25 nM.
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