lifespan

Parishin (Parishin A) A is isolated from the rhizomes of Gastrodia elata. It has good neuroprotective effects against brain disorders.

Cyclogalegenin (Astramembrangenin) is able to elongate telomeres, resulting in increased lifespan of the animals.

Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Qingyangshengenin B has antiepileptic and anti-aging effects, it can extend lifespan, increase heat stress-resistance, delay body paralysis, and increase the chemotaxis response in C. elegans models of Alzheimer's disease. Otophylloside B can suppress the seizure-like locomotor activity caused by pentylenetetrazole in zebrafish.

Ascr#7 is a small-molecule glycolipid pheromone secreted by Caenorhabditis elegans, belonging to the ascaroside family. These compounds are often referred to as "dauer pheromones" and serve as critical chemical signals regulating development, social behavior, and stress responses in nematodes. The expression of Ascr#7 is strongly dependent on diet and developmental stage. Its primary biological function is to induce the formation of long-lived and highly stress-resistant dauer larvae. This mechanism allows nematodes to arrest normal development and enter a specialized diapause state for survival during adverse environmental conditions such as food scarcity or high population density.

Cyclogalegenin (Standard) is a reference standard for research and analysis in studies involving Cyclogalegenin. Cyclogalegenin (Astramembrangenin) is able to elongate telomeres, resulting in increased lifespan of the animals.

Withanolide A (Standard) is a reference standard for research and analysis in studies involving Withanolide A. Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.

Mycothiazole is an inhibitor of mitochondrial electron transport chain (ETC) complex I. It exhibits cytotoxicity in cancer cells Huh7 (IC50 of 55.8 μM), U87, and MCF7. In Huh7 cells, Mycothiazole induces apoptosis (apoptosis). Additionally, Mycothiazole extends the lifespan of C. elegans by modulating transcription factors ATFS-1 and HSF1, which are associated with the unfolded protein response (UPR) and heat shock response (HSR).

AChE-IN-58 (Compound 3) is an acetylcholinesterase (AChE) inhibitor. It has the ability to extend the average lifespan of CL4176 nematodes, delay Aβ1-42-induced paralysis, enhance locomotor activity, and mitigate glutamate (Glu)-induced neurotoxicity.

Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.