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Search Results for " inward "

Targets

37

Compounds

4

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T23101 O-3M3FBS Others
Inactive analog of m-3M3FBS (PLC activator)
T22408 Proflavine 3,6-Diaminoacridine Antibacterial
Proflavine (3,6-Diaminoacridine) (3,6-Diaminoacridine) is a disinfectant bacteriostatic against many gram-positive bacteria and is a topical antiseptic used mainly in wound dressings.
T0438 Proflavine Hemisulfate 3,6-Diaminoacridine hemisulfate,Proflavin hemisulfate Others , Potassium Channel , DNA , Thrombin , Antibacterial , Autophagy
Proflavine Hemisulfate (3,6-Diaminoacridine hemisulfate) is the hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used for cellular imaging and a...
T4542 Clonixin Clonixic acid Others
Clonixin (Clonixic acid) is a non-steroidal anti-inflammatory drug (NSAID) with analgesic properties. This compound has been reported to block prostaglandin synthesis, and to block inward calcium currents.
T21263 Amlodipine maleate Amlodipine (+-)-form maleate,Amvaz Calcium Channel
Amlodipine maleate (Amvaz) is an orally active dihydropyridine calcium channel blocker that inhibits calcium inward flow by blocking voltage-dependent L-type calcium channels.Amlodipine maleate is used in the study of hy...
T27205 DPI 201-106 DPI-201-106 Sodium Channel
DPI-201-106 is a cardioselective inhibitor of the TTX-resistant h1 Na channel inactivation. DPI-201-106 inhibits the L-type calcium current, and inward and delayed rectifier potassium currents.
T36033 DETA NONOate NOC-18,Diethylamine NONOate NO Synthase
DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor with vasodilatory and antidepressant activity.DETA NONOate can be used to activate inward currents in neurons, which may accelerate the healing of MRSA-infect...
T22361 Mepivacaine Carbocaine Sodium Channel
Mepivacaine (Carbocaine) is an amide compound for local anaesthesia that causes transient loss of self-consciousness in humans or animals. mepivacaine acts by binding to specific voltage-gated sodium channels in nerve ce...
T6541 Ibutilide Fumarate Corvert Fumarate,U70226E Calcium Channel , Sodium Channel
Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outwar...
T0207 Ranolazine dihydrochloride RS 43285,Ranolazine 2HCl Calcium Channel , Sodium Channel , Autophagy
Ranolazine dihydrochloride (Ranolazine 2HCl) , an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), and do not affect blood pressure or h...
T0866 Propafenone Rythmol,Propafenonum Potassium Channel , MRP , Sodium Channel
Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity....
T15555 IK1 inhibitor PA-6 Potassium Channel
IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouse KIR2.x currents).
T13387L Zatebradine hydrochloride UL-FS-49CL,UL-FS-49 Others , HCN Channel
Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochl...
T2535 Ivabradine hydrochloride S 16257-2,Ivabradine HCl Adrenergic Receptor
Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gat...
T19839 Oxatomide Oxatomida P2X Receptor , Calcium Channel , 5-HT Receptor , Histamine Receptor
Oxatomide (Oxatomida) is a potent and orally active dual H1 histamine receptor and P2X7 receptor antagonist with antihistamine and antiallergic activity.Oxatomide can be used to block ATP-induced currents in the human P2...
T1046 Mexiletine hydrochloride KOE-1173 (hydrochloride),Mexiletine HCl,KO1173 AhR , Sodium Channel
Mexiletine hydrochloride (KOE-1173 (hydrochloride)) is the hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine exerts its antiarrhyt...
T23012 MNI caged kainic acid Others
Generates large inward currents at resting membrane potential
T24948 VU625 VU007625,VU 625,VU 007625,VU-625,VU-007625
VU625 is an effective inhibitor of Aedes aegypti inward rectifier potassium channels.
T5336L Zacopride Racemic zacopride
Zacopride is a selective agonist of inward rectifier potassium current (I K1) channel, inhibiting ventricular arrhythmias without affecting atrial arrhythmias.
T71406 SA 2572
SA 2572 is a newly synthesized Ca2+ antagonist having a inhibitory effect on the fast Na+ inward channel.
T80510 Tertiapin-RQ Potassium Channel
Tertiapin-RQ, an inward rectifier potassium (K+) channel-blocking peptide, exhibits antidepressant effects [1].
T70063 GYKI 52466 HCl
GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also i...
T68361 Asocainol hydrochloride
Asocainol hydrochloride ia an antiarrhythmic drug which inhibits slow Ca2+ influx. This is accompanied by alterations in normal Na+-carried action potentials. Therefore, Asocainol not only inhibits Ca2+ inflow but also i...
T17240 VU041 Others
VU041 is an inhibitor of Anopheles gambiae and Aedes aegypti inward rectifier potassium 1 channels (IC50: 2.5 μM and 1.7 μM, respectively). VU041 inhibits appreciably is mammalian Kir2.1 (IC50: 12.7 μM) and has less inhi...
TP1967 Phrixotoxin 3
Potent blocker of voltage-gated sodium channels (IC50 values are 0.6, 42, and 72 nM for NaV1.2, NaV1.3 and NaV1.5 respectively). Blocks inward sodium currents in a voltage-dependent manner.
T37093 4,9-Anhydrotetrodotoxin 4,9-Anhydrotetrodotoxin,4,9-anhydro-TTX
4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). [1][2][3] It demonstrate...
T36740 Guanosine 5’-diphosphate (sodium salt hydrate)
Guanosine 5’-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5’-triphosphate .1It has been used to study the conformations of GTPases.2GDP (100 μM) activates sulfonylurea receptor 2B (SUR...
TP2114 Tertiapin-Q
A high affinity blocker for inward-rectifier K+ channels, this compound is a stable derivative of the bee venom toxin tertiapin. Binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are...
T63445 Amlodipine mesylate
Amlodipine mesylate is an oral active dihydropyridine calcium channel blocker that blocks voltage-dependent L-type calcium channels and inhibits calcium inward flow, and is an anti-anginal agent. amlodipine mesylate can ...
T41209 DPNB-ABT 594
DPNB-ABT 594 is a nitrobenzyl-caged ABT 594, a selective α4β2 nAChR agonist. One-photon uncaging evokes large inward currents and Ca2+transients on cell bodies and dendrites of medial habenular neurons in mouse brain sli...
T37199 Bilaid C
Bilaid C is a tetrapeptide μ-opioid receptor agonist (Ki= 210 nM in HEK293 cell membranes expressing the human receptor) that has been found inPenicillium.1It inhibits forskolin-induced cAMP accumulation by 77% in HEK293...
T70987 AT-1001
AT-1001 is an α3β4 nAChR partial agonist. AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats. AT-1001 also potently and reversib...
TP2016 Huwentoxin-IV Huwentoxin IV
Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Inhibits the channel b...
TP1513 Egg Laying Hormone, aplysia
Egg-laying hormone (ELH) is a neuropeptide synthesized by the bag cell neurons, Egg-laying hormone (ELH) induces egg laying and its correlated behavior in Aplysia californica. Egg-laying hormone (ELH) has been purified t...
T83749 Tertiapin LQ TFA TPNLQ
Tertiapin LQ, a peptide derivative of honeybee venom peptide tertiapin, acts as an inhibitor of inwardly rectifying potassium (Kir) channels. Specifically, it targets and inhibits heteromultimeric potassium channels, inc...
T75855 Phrixotoxin 3 TFA
Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels , with IC 50 s of 0.6, 42, 72, 288, 610 nM for NaV1.2 , NaV1.3 , NaV1.4 , NaV1.1 and NaV1.5 , respectively. Phrixotoxin 3 TFA modulates voltage-gated...
T69600 Spermidine-d6
Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µ...

Compounds

o-3M3FBS
T23101
Synonym:
Target: Others
Proflavine
T22408
Synonym: 3,6-Diaminoacridine
Target: Antibacterial
Proflavine Hemisulfate
T0438
Synonym: 3,6-Diaminoacridine hemisulfate,Proflavin hemisulfate
Target: Others, Potassium Channel, DNA, Thrombin, Antibacterial, Autophagy
Clonixin
T4542
Synonym: Clonixic acid
Target: Others
Amlodipine maleate
T21263
Synonym: Amlodipine (+-)-form maleate,Amvaz
Target: Calcium Channel
DPI 201-106
T27205
Synonym: DPI-201-106
Target: Sodium Channel
DETA NONOate
T36033
Synonym: NOC-18,Diethylamine NONOate
Target: NO Synthase
Mepivacaine
T22361
Synonym: Carbocaine
Target: Sodium Channel
Ibutilide Fumarate
T6541
Synonym: Corvert Fumarate,U70226E
Target: Calcium Channel, Sodium Channel
Ranolazine dihydrochloride
T0207
Synonym: RS 43285,Ranolazine 2HCl
Target: Calcium Channel, Sodium Channel, Autophagy
Propafenone
T0866
Synonym: Rythmol,Propafenonum
Target: Potassium Channel, MRP, Sodium Channel
IK1 inhibitor PA-6
T15555
Synonym:
Target: Potassium Channel
Zatebradine hydrochloride
T13387L
Synonym: UL-FS-49CL,UL-FS-49
Target: Others, HCN Channel
Ivabradine hydrochloride
T2535
Synonym: S 16257-2,Ivabradine HCl
Target: Adrenergic Receptor
Oxatomide
T19839
Synonym: Oxatomida
Target: P2X Receptor, Calcium Channel, 5-HT Receptor, Histamine Receptor
Mexiletine hydrochloride
T1046
Synonym: KOE-1173 (hydrochloride),Mexiletine HCl,KO1173
Target: AhR, Sodium Channel
MNI caged kainic acid
T23012
Synonym:
Target: Others
VU625
T24948
Synonym: VU007625,VU 625,VU 007625,VU-625,VU-007625
Target:
Zacopride
T5336L
Synonym: Racemic zacopride
Target:
SA 2572
T71406
Synonym:
Target:
Tertiapin-RQ
T80510
Synonym:
Target: Potassium Channel
GYKI 52466 HCl
T70063
Synonym:
Target:
Asocainol hydrochloride
T68361
Synonym:
Target:
VU041
T17240
Synonym:
Target: Others
Phrixotoxin 3
TP1967
Synonym:
Target:
4,9-Anhydrotetrodotoxin
T37093
Synonym: 4,9-Anhydrotetrodotoxin,4,9-anhydro-TTX
Target:
Guanosine 5’-diphosphate (sodium salt hydrate)
T36740
Synonym:
Target:
Tertiapin-Q
TP2114
Synonym:
Target:
Amlodipine mesylate
T63445
Synonym:
Target:
DPNB-ABT 594
T41209
Synonym:
Target:
Bilaid C
T37199
Synonym:
Target:
AT-1001
T70987
Synonym:
Target:
Huwentoxin-IV
TP2016
Synonym: Huwentoxin IV
Target:
Egg Laying Hormone, aplysia
TP1513
Synonym:
Target:
Tertiapin LQ TFA
T83749
Synonym: TPNLQ
Target:
Phrixotoxin 3 TFA
T75855
Synonym:
Target:
Spermidine-d6
T69600
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T8195 Lotusine Others
Lotusine is a pure alkaloid extracted from the Nelumbo nucifera Gaertn. It shows effects on the action potentials in the myocardium and slow inward current in cardiac Purkinje fibers.
T8040 Cholesterol myristate Cholesteryl myristate,Cholesteryl tetradecanoate Others , Potassium Channel , GABA Receptor , Endogenous Metabolite , AChR
Cholesterol myristate (Cholesteryl myristate) is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as GABAA receptor, the nicotinic acetylcholine receptor...
T78489 Lotusine hydroxide
Lotusine (hydroxide), a pure alkaloid isolated from the green seed embryos of Nelumbo nucifera Gaertn, influences action potentials in myocardial tissue and the slow inward current in cardiac Purkinje fibers [1].
T74193 (R)-IDHP
(R)-IDHP is an isomer of IDHP, a salvia metabolite that exerts vasorelaxant effects by inhibiting Ca 2+ release and Ca 2+ inward flow in voltage-dependent and receptor-operated calcium channels in vascular smooth muscle ...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-01700 SMAD3 Protein, Human, Recombinant (His) Human Baculovirus
The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane...
TMPH-01701 SMAD6 Protein, Human, Recombinant (His & Myc) Human Baculovirus
The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane...
TMPH-01699 SMAD2 Protein, Human, Recombinant (His & SUMO) Human E. coli
The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric ...
TMPH-01548 IFI6 Protein, Human, Recombinant (B2M & His) Human E. coli
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to th...
TargetMol