dgtp

dGTP (2'-Deoxyguanosine-5'-triphosphate) is a guanosine nucleotide highly susceptible to oxidative damage, resulting in 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

7-Deaza-7-propargylamino-dGTP is a dGTP analogue specifically engineered for gene sequencing.

7-Deaza-7-propargylamino-3'-azidomethyl-dGTP is a widely used deoxyguanosine triphosphate (dGTP) analog in next generation sequencing (NGS).

8-Br-dGTP (8-Bromo-dGTP) sodium (Compound 5) is a cis isomer of dGTP, characterized as an 8-bromoguanosine nucleotide. This compound is hydrolyzed by the enzyme hMTH1 protein. It inhibits dGTP-activated ADP reduction, exhibiting a Ki value of 56 μM. During DNA synthesis, 8-Br-dGTP sodium presents no significant genotoxicity or mutagenic potential.

3'-Amino-3'-deoxyguanosine-5'-O-triphosphate (3'-amino-dGTP), an amine-modified nucleotide, effectively terminates RNA strand synthesis as catalyzed by RNA polymerase in E. coli. This compound has also been utilized in creating a non-hydrolyzable derivative of the alarmone guanosine pentaphosphate (pppGpp).

Deoxyguanosine triphosphate trisodium salt (2'-Deoxyguanosine-5'-triphosphate trisodium salt) is a nucleotide precursor for DNA synthesis in cells and can be used in the reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification.

Guanine-2'-deoxy-β-L-ribofuranosyl-5'-O-triphosphate (sodium) is an isomer of dGTP and functions as an inhibitor of telomerase, with an inhibition constant (Ki) of 15 μM for the human enzyme.

7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, functions as a telomerase inhibitor with an IC50 of 11 μM [1].

Sp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate), a sulfur-containing isomer of 2'-deoxyguanosine-5'-O-triphosphate (dGTP), functions as an inhibitor of the deoxynucleoside triphosphate triphosphohydrolase SAMHD1, with an inhibitory constant (Ki) of 820 nM.

7-Deaza-dGTP tetralithium is utilized for the amplification of GC-rich DNA sequences [1].

Biotin-16-dGTP tetralithium is a biotin-labeled dGTP used for tagging oligonucleotides.

8-Oxo-dGTP is an oxidized guanine nucleotide and serves as a critical biomarker of oxidative stress.

3'-Amino-3'-dGTP tetrasodium serves as an analog of GTP, generated by the insertion of an amino group at the C3 position of GTP.

3'-ONH2-dGTP sodium solution (100mM) is a labeled modified deoxynucleotide (dNTP) that releases pyrophosphate to produce fluorescence, offering specialized applications in gene synthesis and sequencing.

7-Deaza-7-propargylamino-dGTP sodium is the sodium salt form of 7-Deaza-7-propargylamino-dGTP. It is an analog of deoxyguanosine triphosphate dGTP and can be used in gene sequencing.

3'-Amino-3'-dGTP sodium is a labeled and modified deoxyoligonucleotide (dNTP) that can release pyrophosphate and generate fluorescence during gene synthesis and sequencing, so it has special application value.

3'-P-dGTP sodium is a labeled and modified deoxyoligonucleotide (dNTP) that can release pyrophosphate and generate fluorescence during gene synthesis and sequencing, so it has special application value.

3'-O-Methylthiomethyl-dGTP sodium is a labeled and modified deoxyoligonucleotide (dNTP) that can release pyrophosphate and generate fluorescence during gene synthesis and sequencing, so it has special application value.

3'-Azidomethyi-dGTP sodium is a labeled and modified deoxyoligonucleotide (dNTP) that can release pyrophosphate and generate fluorescence during gene synthesis and sequencing, so it has special application value.

3'-Bromo ANT-dGTP [3'-O-(5-Bromoanthraniloyl)-2'-deoxyguanosine-5'-O-triphosphate] sodium is a derivative of dGTP.

3'-O-Ac-dGTP sodium is an acetylated derivative of the nucleoside triphosphate 2'-deoxyguanosine-5'-triphosphate.

Sp-dGTPαS tetrasodium is a sulfur-containing isomer of dGTP. It acts as an inhibitor of SAMHD1 triphosphate hydrolase activity, with a Ki value of 820 nM.

Rp-dGTPαS, an enantiomer of the dNTPαS nucleotide, serves as the substrate for SAMHD1, a critical regulator of cellular dNTP levels that curtails the replication of viruses (HIV-1, etc.) in CD4+ myeloid lineage and resting T cells. The SAMHD1 tetrameric complex facilitates the hydrolysis of Rp-dGQTPαS into 2'-deoxynucleosides and triphosphates [1].

dGTPαS sodium is a labeled and modified deoxyoligonucleotide (dNTP) that can release pyrophosphate and generate fluorescence during gene synthesis and sequencing, so it has special application value.