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IACS-4619
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Catalog No. T218041 Copy Product Info
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IACS-4619 (compound 4) is a highly selective 2-aminopyridine-based MTH1 (MutT homolog 1) inhibitor with an IC50 of 0.2 nM. By inhibiting MTH1 from hydrolyzing oxidized purine nucleotides like 8-oxo-dGTP, it prevents MTH1 from stopping the incorporation of these nucleotides into DNA. In MTH1-overexpressing U2OS cells, IACS-4619 significantly inhibits endogenous MTH1 activity, yet it shows no substantial antiproliferative or cytotoxic effects on various human cancer or normal cell lines. IACS-4619 can be utilized for MTH1-targeted research within the field of oncology.
IACS-4619
Cas No. 1884209-98-6
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | IACS-4619 (compound 4) is a highly selective 2-aminopyridine-based MTH1 (MutT homolog 1) inhibitor with an IC50 of 0.2 nM. By inhibiting MTH1 from hydrolyzing oxidized purine nucleotides like 8-oxo-dGTP, it prevents MTH1 from stopping the incorporation of these nucleotides into DNA. In MTH1-overexpressing U2OS cells, IACS-4619 significantly inhibits endogenous MTH1 activity, yet it shows no substantial antiproliferative or cytotoxic effects on various human cancer or normal cell lines. IACS-4619 can be utilized for MTH1-targeted research within the field of oncology. |
| In vitro | IACS-4619 demonstrates good permeability in MDCK cells, a high human plasma protein binding rate, an elevated hepatic microsomal metabolic turnover rate, and strong plasma stability in both rats and humans. In human cancer cell lines (U2OS, SaOS2, etc.) and normal cell lines (WI38, BJ, etc.), IACS-4619 (up to 50 μM) does not exhibit a significant antiproliferative phenotype. |
| Molecular Weight | 195.26 |
| Formula | C10H17N3O |
| Cas No. | 1884209-98-6 |
| Smiles | N=1C=C(C(=NC1N)OCC(C)(C)C)C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: IACS-4619 in vitro | IACS-4619 formula | IACS-4619 molecular weight
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