chaperone — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8986	ML198		Glucokinase
	ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecule treatment for patients suffering from Gaucher disease.		Glucokinase
T4304	Azoramide		Apoptosis , PERK
	Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.		Apoptosis , PERK
T8958	PU-H54		GPR
	PU-H54 is a purine-based inhibitor of Grp94. It is a Grp94-selective resorcinol-based inhibitor isolated through probing of the exclusive binding region of S2 subpocket in Grp94.		GPR
T0920	Ambroxol	Ambroxolum,NA-872	P450 , Autophagy
	Ambroxol (NA-872) is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. The substance is a muco...		P450 , Autophagy
T6234	Ambroxol hydrochloride	Mucosolvan,Mucoangin,Ambroxol HCl	Sodium Channel , Autophagy
	Ambroxol hydrochloride (Mucosolvan) is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.		Sodium Channel , Autophagy
T3324	Lycorine	Galanthidine,Narcissine,Amarylline,Belamarine,Licorine	Apoptosis , Virus Protease , Antibacterial , AChR , Fatty Acid Synthase
	Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
T8989	NCGC 607	NCGC607	Others
	NCGC 607 is a a noninhibitory chaperone of glucocerebrosidase (GCase).		Others
T4663	QX77		Others , Autophagy
	QX77 is a chaperone-mediated autophagy (CMA) activator.		Others , Autophagy
T6284	Onalespib	AT13387,Onalespib (AT13387)	HSP
	Onalespib (AT13387) is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Onalespib selectively binds to Hsp90, thereby inhibiting its chap...		HSP
T15947	MAC13243 HCl		Antibacterial
	MAC13243 HCl, an inhibitor of LolA, a periplasmic chaperone that transports lipoproteins from the inner membrane to the outer membrane, is an antimicrobial agent with specificity and significant inhibitory effects on Gra...		Antibacterial
T30480	BiP inducer X	BIX	Apoptosis
	BiP inducer X (BIX) is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.		Apoptosis
T11718	JI051	JI-051	Gamma-secretase
	JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) to induce cell cycle arrest by inhibiting the transcription of the Notch downstream effector gene, Hes1, and inh...		Gamma-secretase
T67717L	Questiomycin A derivatives 18 TFA
	Questiomycin A derivatives 18 TFA is A Questiomycin A derivative with antibacterial and anticancer activity and inhibition of the expression of the cell-protective ER chaperone protein GRP78.
T36818	Questiomycin A		GPR , Antibacterial
	Questiomycin A is an antibiotic produced in crème fraiche with antibacterial and anticancer activities. Questiomycin A suppresses expression of GRP78, a cell-protective ER chaperone protein.		GPR , Antibacterial
T4361	CBL0137 hydrochloride	CBL0137,CBLC137,Curaxin 137,CBL-C137 hydrochloride,Curaxin-137 hydrochloride	Others , NF-κB , p53
	CBL0137 hydrochloride (Curaxin-137 hydrochloride) activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperone FACT.		Others , NF-κB , p53
T25770	116-9e	MAL-2-11B,MAL2-11B,MAL211B,MAL 2 11B,MAL2 11B	Virus Protease
	116-9e (MAL2-11B) is a potent Hsp70 co-chaperone DNAJA1 inhibitor with antiviral properties, inhibition of simian virus 40 (SV40) replication, inhibition of tumour antigen (TAg) endogenous ATPase activity, and TAg-mediat...		Virus Protease
T8990	ML266		Glucokinase
	ML266, a glucocerebrosidase (GCase) chaperone with an IC50 of 2.5 µM, facilitates the transport of the mutant protein to the lysosome, thereby restoring GCase activity without inhibiting the enzyme's function. This compo...		Glucokinase
T6248	XL888		HSP
	XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50: 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation, cell cycling, and apoptosis....		HSP
T15646	KBU2046		Others
	KBU2046 is an orally administered compound that inhibits cell motility and invasion, effectively suppressing cancer metastasis and extending lifespan. This compound uniquely targets and binds to chaperone heterocomplexes...		Others
T7265	HSP27 inhibitor J2	J2	HSP
	HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function.		HSP