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c-012

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HJC-0123
T706861430420-02-2
Downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER)-negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy.
  • $1,520
6-8 weeks
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QTY
C012 Dihydrochloride
C-012 Dihydrochloride,C 012 Dihydrochloride,C 012 2HCl,C012 2HCl,C-012 2HCl
T306761219163-50-4
C012 Dihydrochloride is a novel small molecule compound that sensitized BRAF wild-type melanoma cells to verofenib. It can significantly reduce the activity of melanoma cells and has limited toxicity to normal human fibroblasts.
    6-8 weeks
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