ards

Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) induces pulmonary vasodilation and inhibits the proliferation of vascular SMCs and platelet aggregation. Avitadil acetate can be used for research on pulmonary fibrosis, pulmonary hypertension (PAH), and respiratory failure caused by SARS-CoV-2.

TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity.

Mulberrofuran C, a benzofuran present in Morus alba, has inhibitory effects on Aβ₁₋₄₂ auto-aggregation, tau protein aggregation, AChE, antioxidant activity and neuroprotective effects, and has anti-Alzheimer's disease potential.

Lipopolysaccharides (LPS), derived from Escherichia coli O55:B5, are essential components of the outer membrane of Gram-negative bacteria. Composed of lipid A, a core oligosaccharide, and an O-specific polysaccharide, LPS exhibits strong immunogenicity. It activates immune cells via the TLR4 receptor, induces chemotactic cell migration and cytokine secretion, and helps maintain the integrity of the bacterial outer membrane, protecting against bile salts and lipid-based antibiotics. LPS is commonly used to establish inflammatory models, including arthritis, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), and gastrointestinal disease models.

Eltenac (B78820) is a non-steroidal anti-inflammatory, COX inhibitor with analgesic activity.Eltenac inhibits COX-1 and COX-2 and is used in the study of Acute Respiratory Distress Syndrome (ARDS).

PNSC928 is an inhibitor of the CtBP2-p300 interaction, with an IC50 of 23.60 µM. It can reverse the expression of pro-inflammatory cytokines induced by Lipopolysaccharides in RAW264.7 cells. Additionally, PNSC928 has the potential to ameliorate acute respiratory distress syndrome (ARDS) in mice.

Nrf2 activator-20 is a potent Nrf2 activator with anti-inflammatory and antioxidant properties. It activates anti-inflammatory pathways by disrupting the interaction between Keap1 and Nrf2, demonstrating beneficial effects in vivo. Nrf2 activator-20 is applicable for studies on acute respiratory distress syndrome (ARDS) and ischemia-reperfusion injury.

Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic double-stranded RNA (dsRNA) analog and an agonist of TLR3 as well as retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5). It can induce innate immune responses in mammals and serve as a vaccine adjuvant to enhance both innate and adaptive immunity, while modulating the tumor microenvironment and directly inducing apoptosis in cancer cells. Poly(I:C) is commonly used to establish acute respiratory distress syndrome (ARDS) animal models for studying immune responses and disease mechanisms.

Tabersonine (Tabersonin)is a terpene indole alkaloid found in the medicinal plant Catharanthus roseus.

SN50 TFA is a cell-permeable inhibitor of NF-κB and attenuates alveolar hypercoagulation and fibrinolysis inhibition in acute respiratory distress syndrome mice through inhibiting NF-κB p65 translocation. SN50 TFA can be used in studies about ARDS.

Nrf2 activator-1 is a potent activator of NF-E2-related factor 2 (Nrf2) and can be used to study COPD and other respiratory diseases, including asthma, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and pulmonary fibrosis.

Lipopolysaccharides from Escherichia coli O111:B4 are key components of the outer membrane of Gram-negative bacteria. As a smooth-type LPS, they consist of lipid A, an R3-type core oligosaccharide, and an O-specific polysaccharide. These LPS molecules exhibit high immunogenicity, can trigger strong immune responses and gastric disorders by activating the TLR-4 receptor on immune cells, and help maintain the structural integrity of the bacterial outer membrane while protecting against bile salts and lipid-based antibiotics. They are widely used to establish inflammation-related disease models, such as chronic obstructive pulmonary disease (COPD) and acute respiratory distress syndrome (ARDS).

P-CAB agent 1 (compound B19) is a potassium-competitive acid blocker with an IC50 of 60.50 nM for H+/K+-ATPase, used in the study of acid-related diseases (ARDs).

IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM). IRAK4-IN-20, which has anti-inflammatory, antitumor and anticancer effects, is often used to treat acute respiratory distress syndrome (ARDS).

AMY-101 acetate (Cp40 acetate) is a cyclic peptide, an inhibitor of C3 Complement and an immunomodulator used in the treatment of gingivitis and periodontitis, which significantly reduces inflammation and lowers MMP-8 and MMP-9 levels.AMY-101 acetate also have a palliative effect on covid -19-induced lung inflammation/injury and SARS-COV-2-related acute kidney injury in patients with acute respiratory distress syndrome (ARDS).

Paridiprubart (NI-0101) is a humanised monoclonal antibody targeting TLR4, demonstrating ameliorative effects in COVID-19 patients with acute respiratory distress syndrome (ARDS) and holding potential for rheumatoid arthritis research.

STC314 is an anti-infective agent that reverses organ damage caused by excessive immune response by neutralizing extracellular histones and neutrophil trapping networks, and can be used in the study of sepsis and acute respiratory distress syndrome (ARDS).STC314 protects the stability of lipid bilayers, and inhibits platelet activation and erythrocyte damage.STC314 is also used in the study of prostate cancer.Nardeterol HCl is a selective kappa agonist with analgesic activity.

Quisovalimab is a fully human monoclonal antibody that specifically binds to and neutralizes LIGHT(TNFSF14), a member of tumor necrosis factor superfamily, thus blocking its interaction with the receptor and inhibiting T cell-related inflammatory response. Quisovalimab has been used to study the inflammatory pathway mediated by LIGHT, and it has potential therapeutic value in COVID-19-related acute respiratory distress syndrome (ARDS) and cytokine release syndrome (CRS).

(±)9(10)-DiHOME, the diol derivative of (±)9(10)-EpOME—a cytochrome P450-derived epoxide of linoleic acid also known as leukotoxin—is formed through the action of soluble epoxide hydrolase (sEH) in neutrophils. It exhibits toxicity towards Sf21 cells expressing sEH as well as tolacZ-expressing control cells, differing from leukotoxin which only harms sEH-containing cells. Furthermore, combined exposure to 9(10)- and 12(13)-DiHOME leads to cell death in rabbit renal proximal tubule cells by disrupting mitochondrial respiration, and causes lung injury, respiratory distress, and mortality in mice, highlighting its role as a toxic lipid mediator. Specifically, 9(10)-DiHOME has been associated with acute respiratory distress syndrome (ARDS), a severe and often deadly complication in patients with major burns. Elevated levels of this compound have been detected in the bronchoalveolar lavage fluid (BALF) of women, but not men, with chronic obstructive pulmonary disease (COPD), and its levels are also increased in patients with allergic asthma, indicating its significance in respiratory conditions.

MS-II-124 is an effective and selective NLRP3 inhibitor (IC50=0.12 μM) with anti-inflammatory and immunomodulatory properties, suitable for the study of Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS).

GSK2862277 is a human monoclonal antibody (mAb) targeting TNFRSF1A. It enhances the formation of neutrophil extracellular traps and boosts the phagocytic activity of alveolar macrophages. GSK2862277 is applicable for research in acute lung injury and acute respiratory distress syndrome (ARDS). Recommended isotype control: VHH-hFc.

S095024 is a humanized IgG1 monoclonal antibody inhibitor targeting CD73. It is applicable in research related to acute respiratory distress syndrome (ARDS), non-small cell lung cancer (NSCLC), and advanced solid tumors [malignant neoplasms].

ALT-100 (Human IgG1) is a humanized monoclonal neutralizing antibody targeting extracellular nicotinamide phosphoribosyltransferase (eNAMPT). This product binds specifically to eNAMPT, blocking its function as a damage-associated molecular pattern (DAMP) that induces pro-inflammatory and pro-fibrotic signaling. ALT-100 effectively inhibits eNAMPT-mediated TLR4 activation, reduces the release of inflammatory cytokines, and suppresses tissue remodeling. It serves as an important pharmacological tool for researching post-infarct myocardial fibrosis, acute respiratory distress syndrome (ARDS), and systemic inflammatory response syndrome.

TABERSONINE HYDROCHLORIDE (Standard) is a reference standard for research and analysis in studies involving TABERSONINE HYDROCHLORIDE. TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity.