anandamide

Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous system.

LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). LY2183240 is a novel and highly effective blocker of anandamide uptake (IC50 = 270 pM).

Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent manner.

OMDM-6 is a dual agonist of TRPV1(EC50 = 75 nM) and CB1 (Ki = 3.2 μM). OMDM-6 inhibits anandamide cellular uptake with a Ki of 7.0 μM.

OMDM-1 ((Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide) is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor with a Ki of 2.4 μM.

OMDM-5 is a selective anandamide cellular uptake (ACU)inhibitor(Ki of 4.8 μM).

C17:1 Anandamide is a type of arachidonoyl ethanolamide.

C18:1 Anandamide is a type of arachidonylethanolamide.

C17:0 anandamide phosphate sodium is a type of arachidonylethanolamine.

C18:2 Anandamide phosphate sodium is a type of arachidonylethanolamine.

OMDM-2 is a metabolically stable and selective inhibitor of anandamide cellular uptake (ACU), exhibiting a Ki value of 3.0 μM in RBL-2H3 cells and demonstrating excellent stability during rat brain homogenate digestion.

OMDM-3 is a selective and metabolically stable anandamide cellular uptake (ACU) inhibitor with a Ki of 16.6 μM.

OMDM-4 is a selective and metabolically stable anandamide cellular uptake (ACU) inhibitor with a Ki of 17.7 μM.

ARN272 is a FAAH-like anandamide transporter (FLAT) inhibitor (IC50: 1.8 μM).

BI-0314 is a selective allosteric STEP activator.

BIA 10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (that is, the rest of the body other than the brain and spinal cord). BIA 10-2474(BIA10-2474) interacts with the human endocannabinoid system. BIA 10-2474(BIA10-2474) was in development for the treatment of a range of different medical conditions from anxiety to Parkinson's disease, also for the treatment of chronic pain of multiple sclerosis, Y, hypertension or the treatment of obesity.

MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective, active-site directed irreversible inhibitor of anandamide amidase, cPLA2, and iPLA2.

ASP8477 is a potent and selective FAAH inhibitor. It increases anandamide levels in the brain when administered orally. In rat models of neuropathic and osteoarthritic pain, ASP8477 demonstrates significant efficacy without causing motor coordination issues. A single oral dose of ASP8477 improves thermal hyperalgesia and cold allodynia in rats with chronic constriction nerve injury. Moreover, ASP8477 restores the decreased muscle pressure threshold in a myalgia model induced by reserpine. Research indicates that ASP8477 possesses analgesic effects effective for alleviating neuropathic and functional pain, making its pharmacological properties suitable for chronic pain treatment.

N-Stearoyltyrosine (N-(1-Oxooctadecyl)-L-tyrosine) is an analog of Anandamide. It exhibits neuroprotective effects by safeguarding the CA1 region of the hippocampus in a gerbil ischemia-reperfusion model. Additionally, N-Stearoyltyrosine inhibits free radical generation, enhances antioxidant capacity, and reduces IR-induced apoptosis (cell apoptosis).

(±)5(6)-EET Ethanolamide is a metabolite derived from Anandamide through oxidation by cytochrome P450 enzymes. It acts as a selective cannabinoid receptor 2 (CB2) agonist. The Ki values for (±)5(6)-EET Ethanolamide against human CB1 and CB2 are 11.4 μM and 8.9 nM, respectively. This compound can be used in studies related to immunoregulation and neuroinflammation.

biotinylated anandamide analog acts as a probe for visualizing the accumulation and intracellular trafficking of anandamide

anandamide uptake inhibitor

anandamide transport inhibitor

N-Decanoyl p-nitroaniline (DepNA) is a nitroaniline fatty acid amide used to measure fatty acid amide hydrolase (FAAH) activity. FAAH, which accepts various amide head groups beyond the ethanolamine of its endogenous substrate anandamide (AEA), can hydrolyze fatty acid amides with fewer carbons and fewer double bonds than arachidonate. When exposed to FAAH activity, DepNA releases the yellow colorimetric dye p-nitroaniline (ε = 13,500 at 410 nm), enabling fast and convenient FAAH activity measurement using a 96-well plate spectrophotometer.