a 274

A 274 is a highly aromatic, monosubstituted phenol antioxidant generated during differentiation of neuroblastoma cells.

Antibacterialagent 274 (Compound 18b) is an antibacterial agent that targets bacterial cell membranes, exhibiting a minimum inhibitory concentration (MIC) of 8 μg/mL against Acinetobacter baumannii ATCC 17978. It functions by disrupting membrane integrity, causing intracellular accumulation of ROS, which leads to DNA and protein leakage, thereby exerting its antibacterial effects. Antibacterialagent 274 is applicable in research on infections caused by Gram-negative bacteria.

Anticanceragent 274 (Compound 1) is a Sorafenib analog that inhibits tumor cell growth, with IC50 values of 0.034 μM and 0.042 μM for SaOS-2 and MNNG-HOS cells, respectively. It exhibits low toxicity to normal cells and can be utilized in osteosarcoma and other tumor research.

CRBN ligand-274 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), utilized for cereblon protein recruitment. This compound can be linked via a linker to a target protein ligand to form a PROTAC.

GNE-274, a non-degrader compound structurally similar to GDC-0927 (an ER degrader), serves as a partial ER agonist in breast cancer cell lines without triggering ER turnover. Notably, GNE-274 enhances chromatin accessibility at ER-DNA binding sites, unlike GDC-0927. Acting as a potent inhibitor of the ER-ligand binding domain (LBD), GNE-274 exhibits potential for cancer research purposes.

NCX-274 is a ROCK inhibitor and NO-donating anti-glaucoma agent

ABI-274 is a novel potent colchicine binding site inhibitor (CBSI) and tubulin inhibitor.

HIV gp120 254-274, a conserved fragment of the envelope glycoprotein gp120 from the human immunodeficiency virus (HIV), displays immunosilent activity [1].

(R)-GNE-274 is the chiral isomer of GNE-274. GNE-274 serves as a structural analogue of the ER degrader, GDC-0927, but does not function as a degrader itself.

FD274 is a potent dual PI3K/mTOR inhibitor with inhibitory effects on PI3Kα/β/γ/δ and mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM, respectively. FD274 showed significant antiproliferative activity in AML cell line antiproliferative assays. FD274 exhibited dose-dependent pit tumor growth activity in an HL-60 xenograft model. FD274 has potential for use in acute myeloid leukemia studies.

Asiaticoside (Emdecassol) (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burns.

1,3-Benzodioxole ,with CAS No. 274-09-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1,3-Benzodioxole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Imidazo[1,2-a]pyridine ,with CAS No. 274-76-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Imidazo[1,2-a]pyridine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Imidazo[1,2-a]pyrazine ,with CAS No. 274-79-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Imidazo[1,2-a]pyrazine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Pyrazolo[1,5-a]pyrimidine ,with CAS No. 274-71-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Pyrazolo[1,5-a]pyrimidine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1,7,9-Triazabicyclo[4.3.0]nona-2,4,6,8-tetraene ,with CAS No. 274-85-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1,7,9-Triazabicyclo[4.3.0]nona-2,4,6,8-tetraene provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

MS-8709 is a potent and selective G9a/GLP PROTAC Degrader with a DC50(G9a) of 274 nM and a DC50(GLP) of 260 nM. It induces G9a/GLP protein degradation in a concentration-dependent and time-dependent manner via the ubiquitin-proteasome system, without affecting mRNA expression levels. MS-8709 demonstrates superior cell growth inhibition compared to the parent compound UNC0642 in prostate cancer, leukemia, and lung cancer cell models, and exhibits mouse pharmacokinetic characteristics suitable for in vivo efficacy studies.

BPP-2 is a GHSR ligand containing the element F. By labeling BPP-2 with the isotope 18F, a PET probe targeting GHSR can be produced. The binding affinity (Ki) of 18F-BPP-2 for GHSR is 274 nM.

NSD2-IN-6 is a selective inhibitor of NSD2, with an IC50 of 3.8 nM for NSD2 and 274 nM for NSD1. It reduces H3K36me2 levels and reverses cellular plasticity by restoring androgen receptor (AR) signaling pathways. In organoid models, NSD2-IN-6 prompts a transition of cell states from cluster 2 and cluster 3 to cluster 1. In vivo, it exhibits antitumor activity by reversing tumor cell plasticity, inhibiting growth, and promoting apoptosis. NSD2-IN-6 is useful for research in prostate cancer.

P53 mutant stabilizer-1 (compound 274) is a covalent stabilizer for the mutant form of p53. It can be utilized in studies related to the wild-type functions of p53 mutants, such as those associated with p53 mutations in cancer.

D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor.1,2It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growthin vitroat 20 μM and significantly inhibits DNA synthesis at 3 μM.3[Matreya, LLC. Catalog No. 1865] 1.Shen, W., Henry, A.G., Paumier, K.L., et al.Inhibition of glucosylceramide synthase stimulates autophagy flux in neuronsJ. Neurochem.129(5)884-894(2014) 2.Lee, L., Abe, A., and Shayman, J.A.Improved inhibitors of glucosylceramide synthaseJ. Biol. Chem.274(21)14662-14669(1999) 3.Abe, A., Inokuchi, J.-i., Jimbo, M., et al.Improved inhibitors of glucosylceramide synthaseJ. Biochem.111(2)191-196(1992)

Enpp-1-IN-17 (example 274) is a potent inhibitor of ENPP1, with inhibition constants (Ki values) ranging from 100 nM to 1 μM for cGAMP hydrolysis and greater than 1 μM for ATP hydrolysis, demonstrating a selectivity ratio of over 6.4 favoring cGAMP hydrolysis inhibition [1].

Sodium lactate ringer's solution is an isotonic crystalloid solution used to regulate body fluids, electrolytes, and acid-base balance, and it is effective for fluid replenishment during the perioperative period (perioperative). This solution consists of a sterile aqueous solution of sodium lactate, sodium chloride, potassium chloride, and calcium chloride (RL, 130 mEq sodium/L, 274 mOsm/L).