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Search Results for " rho-kinase "

Targets

64

Compounds

2

Natural Products

5

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T12721 Rho-Kinase-IN-1 ROCK
Rho-Kinase-IN-1 is an inhibitor of ROCK with Kis of 30.5 nM and 3.9 nM for ROCK1 and ROCK2, respectively. Rho-Kinase-IN-1 can be used in studies about excessive cell proliferation, remodeling, edema and inflammation dise...
T2633 GSK429286A RHO-15 ROCK
GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
T2155 Thiazovivin ROCK
Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.
T14960 Chroman 1 ROCK
Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM).
TQ0187 SR-3677 ROCK , Autophagy
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
T12747 ROCK2-IN-2 ROCK
ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).
T1870 Y-27632 ROCK , Apoptosis
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
T7301 BDP5290 ROCK
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
T1898 RKI-1447 RKI1447 ROCK
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
T3513 GSK180736A GSK180736 ROCK , GRK , PKA
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM).
T7391 SAR407899 ROCK , Rho
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
T12746 ROCK inhibitor-2 ROCK
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).
T7885 Afuresertib hydrochloride ROCK , Akt , PKC
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
T2482 AT13148 ROCK , SGK , Akt , PKA , S6 Kinase
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T14989 CMPD101 ROCK , GRK , PKC
CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with I...
T7648 HA-100 Myosin , PKA , PKC
HA-100 is an inhibitor of protein kinase
T4488 GSK-25 GSK25 ROCK , S6 Kinase , mTOR
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).
T4095 ZINC00881524 ROCK inhibitor ROCK
ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.
T1911 Afuresertib GSK2110183C,GSK2110183 ROCK , Akt , PKC
Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
T2011 RKI1313 RKI 1313,RKI-1313 ROCK
RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion.
T7764 CCG-222740 ROCK , Rho , Ras
CCG-222740 is an inhibitor of Rho/MRTF pathway
T13384L Y-33075 dihydrochloride CaMK , ROCK , PKC
Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
T4276L Hydroxyfasudil Hydroxy-Fasudil,HA-1100 ROCK , PKA
Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
TQ0110 ROCK-IN-2 TC-S 7001,Azaindole 1 ROCK
ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
TQ0319 Ripasudil K-115,Ripasudil hydrochloride dihydrate ROCK
Ripasudil (Ripasudil hydrochloride dihydrate) (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2).
T6867 Belumosudil KD025,Rezurock,ROCK inhibitor,SLx-2119 ROCK
Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).
T23308 SAR407899 hydrochloride ROCK
ATP-competitive ROCK inhibitor
T3518 GSK269962A GSK269962B,GSK 269962,GSK269962A HCl ROCK , S6 Kinase
GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
T4276 Hydroxyfasudil Hydrochloride Hydroxyfasudil (HA-1100) HCl,HA 1100 hydrochloride ROCK
Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
T61497 Rho-Kinase-IN-2
Rho-Kinase-IN-2 (Compound 23) is an orally active and selective inhibitor of Rho Kinase (ROCK), which can penetrate the central nervous system (CNS). It exhibits a high affinity for ROCK2 with an inhibition constant (IC5...
T1606 Fasudil HA-1077,AT877 ROCK , Serine/threonin kinase , Calcium Channel , PKA , PKC , Autophagy
Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T1725 Y-27632 dihydrochloride Y-27632 2HCl ROCK , Apoptosis
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
T3060 Fasudil hydrochloride Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877 ROCK , Serine/threonin kinase , Calcium Channel , HIV Protease , PKA , PKC , Autophagy
Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
T7552 H-1152 ROCK
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
T15798 LX7101 ROCK , LIM Kinase , PKA
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
T7492 Ripasudil free base K-115 (free base) ROCK , Antibacterial
Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
T26078 Rhodblock 6 Rhodblock6,Rhodblock-6 ROCK
Rhodblock 6 is a Rho kinase (ROCK) inhibitor that inhibits the localization of phosphorylated MRLC (Myosin Regulatory Light Chain) and acts by specifically inhibiting Rho kinase activity.
T10358 Netarsudil Dihydrochloride AR-13324 Dihydrochloride ROCK
Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction.
T36196 CAY10746 ROCK
CAY10746 is a selective Rho kinase (ROCK) inhibitor that inhibits ROCK I and ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively.CAY10746 can be used to study diabetic retinopathy.
T35328 H-1152 dihydrochloride H-1152 2HCl,H-1152 dihydrochloride ROCK
H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 ...
T60924 Verosudil AR-12286 ROCK
Verosudil (AR-12286) is a highly potent Rho kinase (ROCK) inhibitor with a Ki of 2 and 2 nM against ROCK1 and ROCK2, respectively. AR-12286 reverses steroid-induced intraocular pressure in mice by decreasing intraocular ...
T24722 ROCK-IN-32 ROCK-inhibitor-32,ROCK inhibitor 32
ROCK-IN-32 is an effective Rho-kinase inhibitor.
T69132 NSC-4231
NSC-4231 is a novel Rho-Kinase-II Inhibitor with Vasodilatory Activity.
T69142 NSC-2888
NSC-2888 is a Novel Rho-Kinase-II Inhibitor with Vasodilatory Activity.
T71106 Cotosudil 2HCl
Cotosudil 2HCl is the salt form of Cotosudil Free Base, a Rho-associated (ROCK) kinase inhibitor.
T28387 PF-4950834 PF 4950834,PF4950834
PF-4950834, a ATP-competitive, selective Rho kinase inhibitor, provides therapeutic benefits in chronic inflammatory diseases.
T69123 NSC-2488
NSC-2488 is a novel Rho-Kinase-II Inhibitor with Vasodilatory Activity.
T28469 PT-262 PT 262
PT-262 is a ROCK (Rho-associated coiled-coil forming protein kinase) inhibitor. It induces cytoskeleton remodeling and migration inhibition in lung carcinoma cells.
T69665 Zelasudil
Zelasudil is a Rho-associated (ROCK) kinase inhibitor. Zelasudil has a ROCK2 binding affinity .
T10358L2 Netarsudil mesylate AR-13324 (mesylate) Others
Netarsudil mesylate is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction.

Compounds

Rho-Kinase-IN-1
T12721
Synonym:
Target: ROCK
GSK429286A
T2633
Synonym: RHO-15
Target: ROCK
Thiazovivin
T2155
Synonym:
Target: ROCK
Chroman 1
T14960
Synonym:
Target: ROCK
SR-3677
TQ0187
Synonym:
Target: ROCK, Autophagy
ROCK2-IN-2
T12747
Synonym:
Target: ROCK
Y-27632
T1870
Synonym:
Target: ROCK, Apoptosis
BDP5290
T7301
Synonym:
Target: ROCK
RKI-1447
T1898
Synonym: RKI1447
Target: ROCK
GSK180736A
T3513
Synonym: GSK180736
Target: ROCK, GRK, PKA
SAR407899
T7391
Synonym:
Target: ROCK, Rho
ROCK inhibitor-2
T12746
Synonym:
Target: ROCK
Afuresertib hydrochloride
T7885
Synonym:
Target: ROCK, Akt, PKC
AT13148
T2482
Synonym:
Target: ROCK, SGK, Akt, PKA, S6 Kinase
CMPD101
T14989
Synonym:
Target: ROCK, GRK, PKC
HA-100
T7648
Synonym:
Target: Myosin, PKA, PKC
GSK-25
T4488
Synonym: GSK25
Target: ROCK, S6 Kinase, mTOR
ZINC00881524
T4095
Synonym: ROCK inhibitor
Target: ROCK
Afuresertib
T1911
Synonym: GSK2110183C,GSK2110183
Target: ROCK, Akt, PKC
RKI1313
T2011
Synonym: RKI 1313,RKI-1313
Target: ROCK
CCG-222740
T7764
Synonym:
Target: ROCK, Rho, Ras
Y-33075 dihydrochloride
T13384L
Synonym:
Target: CaMK, ROCK, PKC
Hydroxyfasudil
T4276L
Synonym: Hydroxy-Fasudil,HA-1100
Target: ROCK, PKA
ROCK-IN-2
TQ0110
Synonym: TC-S 7001,Azaindole 1
Target: ROCK
Ripasudil
TQ0319
Synonym: K-115,Ripasudil hydrochloride dihydrate
Target: ROCK
Belumosudil
T6867
Synonym: KD025,Rezurock,ROCK inhibitor,SLx-2119
Target: ROCK
SAR407899 hydrochloride
T23308
Synonym:
Target: ROCK
GSK269962A
T3518
Synonym: GSK269962B,GSK 269962,GSK269962A HCl
Target: ROCK, S6 Kinase
Hydroxyfasudil Hydrochloride
T4276
Synonym: Hydroxyfasudil (HA-1100) HCl,HA 1100 hydrochloride
Target: ROCK
Rho-Kinase-IN-2
T61497
Synonym:
Target:
Fasudil
T1606
Synonym: HA-1077,AT877
Target: ROCK, Serine/threonin kinase, Calcium Channel, PKA, PKC, Autophagy
Y-27632 dihydrochloride
T1725
Synonym: Y-27632 2HCl
Target: ROCK, Apoptosis
Fasudil hydrochloride
T3060
Synonym: Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877
Target: ROCK, Serine/threonin kinase, Calcium Channel, HIV Protease, PKA, PKC, Autophagy
H-1152
T7552
Synonym:
Target: ROCK
LX7101
T15798
Synonym:
Target: ROCK, LIM Kinase, PKA
Ripasudil free base
T7492
Synonym: K-115 (free base)
Target: ROCK, Antibacterial
Rhodblock 6
T26078
Synonym: Rhodblock6,Rhodblock-6
Target: ROCK
Netarsudil Dihydrochloride
T10358
Synonym: AR-13324 Dihydrochloride
Target: ROCK
CAY10746
T36196
Synonym:
Target: ROCK
H-1152 dihydrochloride
T35328
Synonym: H-1152 2HCl,H-1152 dihydrochloride
Target: ROCK
Verosudil
T60924
Synonym: AR-12286
Target: ROCK
ROCK-IN-32
T24722
Synonym: ROCK-inhibitor-32,ROCK inhibitor 32
Target:
NSC-4231
T69132
Synonym:
Target:
NSC-2888
T69142
Synonym:
Target:
Cotosudil 2HCl
T71106
Synonym:
Target:
PF-4950834
T28387
Synonym: PF 4950834,PF4950834
Target:
NSC-2488
T69123
Synonym:
Target:
PT-262
T28469
Synonym: PT 262
Target:
Zelasudil
T69665
Synonym:
Target:
Netarsudil mesylate
T10358L2
Synonym: AR-13324 (mesylate)
Target: Others
1 2
Cat No. Product Name Synonyms Targets
TQ0183 Narciclasine Lycoricidinol ROCK
Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
T4969 Guanosine 5'-triphosphate trisodium salt GTP Trisodium salt,5'-GTP trisodium salt Endogenous Metabolite
Guanosine 5'-triphosphate trisodium salt (5'-GTP trisodium salt) activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of se...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-01958 RhoA Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Transforming protein RhoA, also known as Rho cDNA clone 12, Ras homolog gene family member A, RHOA and ARH12, is a cell membrane and cytoplasm protein that belongs to the small GTPase superfamily and Rho family. The Rho ...
TMPH-01620 TNF beta Protein, Human, Recombinant (His) Human HEK293
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Negativ...
TMPH-02509 ANGPTL8 Protein, Mouse, Recombinant (E. coli, His) Mouse E. coli
Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration...
TMPY-04397 PAK-3 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
PAK3 is a member of PAK proteins, a family of serine/threonine p21-activating kinases, serve as effectors of small Rho GTPases Cdc42 and RAC and have been implicated in a wide range of biological activities. There are si...
TMPH-01547 Interferon alpha 21/IFNA21 Protein, Human, Recombinant (His) Human E. coli
Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to ...
Cat No. Product Name
L7700 Neural Regeneration Compound Library

529 compounds
A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening;
TargetMol