cdc42 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T61448	AZA1	Rac1/Cdc42-IN-1	Apoptosis , Rho , CDK
	AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration and invasion.		Apoptosis , Rho , CDK
T1855	ZCL278	ZCL 278	CDK , Ras
	ZCL278 is a selective Cdc42 GTPase inhibitor.		CDK , Ras
T22106	MLS-573151		CDK , Ras
	MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM). It is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding...		CDK , Ras
T2427	EHop-016	EHop 016	Rho , Ras
	EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.		Rho , Ras
T3196	GNF-7	GNF7	Bcr-Abl , ACK , AChR
	GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.		Bcr-Abl , ACK , AChR
T5092	AIM-100	AIM100	ACK
	AIM-100 is a Ack1 inhibitor (IC50: 24 nM).		ACK
T8930	CID44216842	KUC103479N-02	CDK , Ras
	CID44216842 (KUC103479N-02) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT...		CDK , Ras
T2641	KRCA-0008	KRCA 0008,KRCA0008	ACK , ALK
	KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.		ACK , ALK
T16021	MBQ-167		CDK , Ras
	MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).		CDK , Ras
T2463	ML141	CID-2950007	Apoptosis , CDK , Ras
	ML141 (CID-2950007) is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).		Apoptosis , CDK , Ras
T3971	CASIN	Pirl1-related Compound 2	CDK , STAT , Ras
	CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).		CDK , STAT , Ras
T25125	AZA197	AZA 197,AZA-197	CDK
	AZA197 (AZA-197) is a selective Cdc42 inhibitor. It acts by inhibiting primary colon cancer growth and prolonging survival in a preclinical mouse xenograft model by downregulation of PAK1 activity.		CDK
T6342	NSC 23766 trihydrochloride	Rac1 Inhibitor,NSC 23766	Apoptosis , Rho , Ras
	NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related targets, RhoA or Cdc42.		Apoptosis , Rho , Ras
T16745	Rhosin hydrochloride		Apoptosis , Rho , Ras
	Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin hydrochloride does not interact with Cdc42 o...		Apoptosis , Rho , Ras
T5S1981	Alpha-Cyperone	(+)-α-Cyperone,α-Cyperone	Others , Endogenous Metabolite
	1. alpha-Cyperone (α-Cyperone) is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium. 2. alpha-Cyperone significantly inhibited PGE2 production by suppressing the LPS-induced...		Others , Endogenous Metabolite
T26382	2-Mc-1,4-NHQ	NSC 111552,NSC-111552,NSC111552
	2-Mc-1,4-NHQ, an inhibitor of the Cdc42-PBD interaction, blocks the association of Cdc42 with the PBD.
T61182	(R)-BDP9066
	(R)-BDP9066 is a highly effective inhibitor of myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK), effectively impeding cancer cell invasion, making it an invaluable resource for studying and researching proli...
T68740	NVP-TAC544
	NVP-TAC544 is a novel focal adhesion kinase (FAK) inhibitor, potently blocking kinase activity of FAK along with Aurora A, activated Cdc42-associated kinase 1 (ACK1), Met, insulin receptor (IR), TrkA, and IGF-1R.
T16746	Rhosin		Rho
	Rhosin is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin does not interact with Cdc42 or Rac1, nor the GEF, LARG. R...		Rho
T72363	Antiangiogenic agent 3
	Antiangiogenic agent 3 is a potent inhibitor of human umbilical vein endothelial cells (HUVEC), effectively blocking HUVEC migration and chemotactic motilities. Additionally, it suppresses the gene expression of Src, cdc...