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Adenylate

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    76
    TargetMol | Inhibitors_Agonists
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    14
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    TargetMol | Inhibitors_Agonists
Adenylate
T736189013-02-9
Adenylate (Adk), also known as myokinase, is a phosphotransferase enzyme that catalyzes the interconversion of adenosine phosphates, playing a crucial role in the regulation of phosphate nucleotide levels and cellular energy homeostasis [1]. This enzyme is frequently utilized in biochemical research.
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20 days
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Phenylalanyl adenylate
Phe-pA
T3401835874-27-2
Phenylalanyl adenylate is a bioactive chemical.
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Tryptophyl adenylate
T3496131528-64-0
Tryptophyl adenylate is a bioactive chemical.
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Valyl adenylate
Valyladenylate,Valyl-adenylate
T3503152435-65-1
Valyl adenylate is a peptide.
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Forskolin
FSK, Colforsin, Coleonol
T293966575-29-9
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the heart, and has platelet anticoagulant and antihypertensive effects.
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NB001
HTS 09836
T16275686301-48-4In house
NB001 (HTS 09836) is an adenyl cyclase 1 inhibitor that affects both neural and non-neural pain.
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6-8 weeks
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9-CP-Ade Mesylate
9-Cyclopentyladenine monomethanesulfonate, 9 CP Ade Mesylate, 9CPAde Mesylate
T23588189639-09-6In house
9-CP-Ade Mesylate (9 CP Ade Mesylate) is a cell-permeable, stable and non-competitive inhibitor of adenylate cyclase.
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6-8 weeks
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9-Cyclopentyladenine
NSC19486, NSC 19486, 9CPAde, 9-CP-Ade, 9 CP Ade, NSC-19486
T29652715-91-3In house
9-Cyclopentyladenine (NSC-19486) is an adenylate cyclase inhibitor that blocks cellular morphological differentiation and phosphorylation of specific signaling molecules.
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Bithionol
Actamer
T083097-18-7
Bithionol (Actamer), formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the NDA's for bithionol drug products were withdrawn on October 24, 1967.
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Salbutamol
Albuterol, AH-3365
T113918559-94-9
Salbutamol (Albuterol) stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3', 5'-adenosine monophosphate (cAMP). Salbutamol Sulfate is the sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Increased cAMP concentrations relax the bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent, Salbutamol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction.
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KH7
T15658330676-02-3
KH7 is a soluble inhibitor of adenylyl cyclase (sAC)-specific. It has IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibitor.
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Prostaglandin E1
PGE1, Alprostadil
T1626745-65-3
Prostaglandin E1 (Alprostadil) is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Prostaglandin E1 is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP.
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NKH477
NKH 477, Colforsin dapropate hydrochloride
T16332138605-00-2
NKH477 (Colforsin dapropate hydrochloride) is a derivative of forskolin with antidepressant activity. It inhibits ACh-induced Ca2+ mobilization by acting on ionomycin-sensitive storage sites. NKH477 is an adenylyl cyclase activator with bronchodilatory effects, inhibiting the production of CTL, T-cell proliferation in mixed lymphocyte reactions (MLR), as well as IL-2 production and mitogen responses.
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7-10 days
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SQ22536
SQ 22536, 9-(tetrahydrofuran-2-yl)-9h-purin-6-amine
T217217318-31-9
SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) , the adenosine analogue 9-(Tetrahydro-2-furyl)adenine, inhibited adenylate cyclase activity of crude membrane preparations from catfish (Ictalurus melas) and rat isolated hepatocytes in a non-competitive manner.
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Fipexide
T032234161-24-5
Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France and Italy, mainly for the therapy of senile dementia, but is no longer in common use because of the occurrence of rare drug side-effects including hepatitis and fever.
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2',5'-Dideoxyadenosine
T100666698-26-6
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor, binding to the P-site with an IC50 of 3 μM.
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Lysipressin
Lysine vasopressin, [Lys8]-Vasopressin
T1191850-57-7
Lysipressin ([Lys8]-Vasopressin), Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase. Lysipressin is Antidiuretic hormone that have been found in pigs and some marsupial families.
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Lysipressin acetate(50-57-7(fb_acetate))
Lysine vasopressin acetate, [Lys8]-Vasopressin acetate
T11918L83968-49-4
Lysipressin acetate(50-57-7(fb_acetate)) ([Lys8]-Vasopressin acetate) , Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase. Lysipressin is Antidiuretic hormone that have been found in pigs and some marsupial families.
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N6-Methyladenosine 5'-monophosphate disodium salt
T1216281921-35-9
N6-Methyladenosine 5'-monophosphate disodium salt is a glycogen phosphorylase b activator and an inhibitor of adenylate kinase II.
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7-10 days
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Adenylosuccinic acid
Aspartyl adenylate, Adenylosuccinate
T1412919046-78-7
Adenylosuccinic acid (Adenylosuccinate) is a purine nucleotide cycle metabolite and a novel inducer of the Nrf2 cell protector. It can be used for research on Duchenne muscular dystrophy (DMD).
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CB-7921220
6-[2-(4-Aminophenyl)vinyl]-2-pyridinecarboxylic acid, 6-(4-Aminostyryl)picolinic acid, 6-[(E)-2-(4-aminophenyl)ethenyl]pyridine-2-carboxylic acid
T14880115453-99-1
CB-7921220 (6-[2-(4-Aminophenyl)vinyl]-2-pyridinecarboxylic acid) is an inhibitor of adenylate cyclase.
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6-8 weeks
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ST034307
T16938133406-29-8
ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).
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Ap4dT
T2031161146545-74-5
Ap4dT serves as an inhibitor of human adenylate kinase isozyme 1 (hAK1), effectively suppressing the synthesis of ATP and ADP, with IC50 values of 42 μM and 38 μM, respectively.
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2-Chloro-ADP
2-Chloroadenosine 5′-diphosphate
T20365216506-88-0
2-Chloro-ADP (2-Chloroadenosine 5′-diphosphate) is a derivative of Adenosine 5'-diphosphate (ADP) that induces platelet aggregation and inhibits stimulated adenylate cyclase. Additionally, 2-Chloro-ADP can inhibit the nucleotide-binding domain (NBD) of Mortalin with a Ki value of 45.05 μM.
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