5'-nucleotidase, ecto

PSB-12379 ditriethylamine salt, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).

N-[(4-Aminophenyl)methyl]adenosine is an adenosine receptor inhibitor with a Ki of 29 nM for Rat ecto-5′-Nucleotidase.

Adenosine 5'-methylenediphosphate (sodium salt) is also referred to as an inhibitor of ecto-5'-nucleotidase.

PSB-24000 (Compound 27) is a selective ecto-5'-nucleotidase (CD73) inhibitor with a Ki value of 563 nM for inhibiting human CD73, and a Ki of 481 nM in membrane-bound CD73 in triple-negative breast cancer cells. It disrupts CD73’s recognition and action on substrate AMP, preventing AMP-induced immunosuppressive and pro-cancer adenosine production. PSB-24000 is promising for cancer research.

CD73-IN-21 (Compound 12f) is an inhibitor of ecto-5′-nucleotidase (CD73), with Ki values of 20 nM for hCD73 and 302 nM for mCD73. It is applicable in research related to cancers, such as breast cancer.

COPCP trisodium (Compound 7a) is a potent and selective inhibitor of the ecto-5'-nucleotidase CD73. By blocking CD73-mediated adenosine production, it reduces adenosine's inhibitory effects on immune cells. COPCP trisodium shows promise for cancer research.

Adenosine 5'-methylenediphosphate is an inhibitor of ecto-5'-nucleotidase, also known as CD73, with a Kivalue of 37 nM.1It inhibits cAMP accumulation induced by adenosine 5'-monophosphate , adenosine 5'-diphosphate , or adenosine 5'-triphosphate but not adenosine in VA-13 human fibroblasts when used at a concentration of 100 μM. Adenosine 5'-methylenediphosphate reduces proliferation of U138MG glioma cells, as well as inhibits the invasion and migration of MHCC97H hepatocellular carcinoma (HCC) cells in a migration assay.2,3It increases tumor infiltration of CD3+CD8+T cells and reduces tumor growth in a K1735 murine melanoma model when administered at a dose of 400 μg/mouse.4 1.Bruns, R.F.Adenosine receptor activation by adenine nucleotides requires conversion of the nucleotides to adenosineNaunyn Schmiedebergs Arch. Pharmacol.315(1)5-13(1980) 2.Braganhol, E., Tamajusuku, A.S.K., Bernardi, A., et al.Ecto-5′-nucleotidase/CD73 inhibition by quercetin in the human U138MG glioma cell lineBiochim. Biophys. Acta1770(9)1352-1359(2007) 3.Shali, S., Yu, J., Zhang, X., et al.Ecto\5′\nucleotidase (CD73) is a potential target of hepatocellular carcinomaJ. Cell Physiol.234(7)10248-10259(2018) 4.Forte, G., Sorrentino, R., Montinaro, A., et al.Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanomaJ. Immunol.189(5)2226-2233(2021)

AMPCP is an Ecto-5'-nucleotidase (CD73) inhibitor.

PSB-12379 disodium is a nucleotide analogue acting as a potent inhibitor of Ecto-5'-Nucleotidase (CD73), demonstrating inhibitory constants (Ki) of 9.03 nM in rats and 2.21 nM in humans [1] [2].

Uliledlimab is a humanized monoclonal antibody with potent inhibitory activity against CD73, the ecto-5'-nucleotidase enzyme that catalyzes the conversion of extracellular AMP to adenosine. Uliledlimab reduces extracellular adenosine production, thereby modulating immunosuppressive pathways. Uliledlimab holds significant potential for use in immuno-oncology and cancer research.

Ucenprubart (NZV930) is a high-affinity humanized monoclonal antibody that specifically targets CD73 (ecto-5'-nucleotidase). By inhibiting the enzymatic activity of CD73, Ucenprubart prevents the conversion of extracellular AMP into the immunosuppressive metabolite adenosine, thereby relieving immunosuppression in the tumor microenvironment and promoting antitumor immunity. It is widely investigated in cancer immunotherapy research.

Acid Phosphatase, Prostatic (ACP/PAP) (also known as Acid Phos, 5'-nucleotidase, Thiamine monophosphatase, PAPf39) can be utilized as a biological material or organic compound pertinent to life sciences research.