Gynostemma

Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition

Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities.

anticancer

Gypenoside XVII (Gynosaponin S) confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, activation of Nrf2/ARE/HO-1 and inactivation of GSK-3β pathways.

Gynostemma Extract (Gypenoside IX) is a saponins extract derived from the Gynostemma pentaphyllum.

Gynosaponin I is a natural product from Gynostemma pentaphyllum.

Damulin A is an active dammarane-type saponin isolated from Gynostemma pentaphyllum and belongs to a group of structurally related compounds whose anticancer structure–activity relationships have been deeply explored. Comparative investigations reveal that double bonds positioned at C20(21) and C20(22) and hydroxyl modification at C-2 significantly contribute to cytotoxicity, as evidenced by proliferation inhibition in A549 cells. These findings confirm the importance of Damulin A within the broader context of Gynostemma-derived anticancer leads.

Gypenoside XIII is a Gynostemma pentaphyllum-derived gypenoside that exhibits pharmacological actions consistent with its structural class, including anti-Alzheimer’s disease, anticancer, and anti-atherogenic activities, supporting its emerging significance as a multifunctional natural compound with broad therapeutic potential for neurodegenerative and systemic disorders.

Gypenoside LXXV is a natural saponin discovered in Panax ginseng that binds to the glucocorticoid receptor and translocates into the cell nucleus, thereby promoting wound healing and upregulating CTGF.

Yixingensin is a flavonoid glycoside derived from Gynostemma pentaphyllum, with antioxidant activity.

Gylongiposide I is a natural triterpenoid saponin capable of inhibiting HIF-1α mRNA expression.

Gypenoside LI is a natural product with anticancer activity that generates ROS, downregulates procaspase-8 and MMP-2/9, inhibits Wnt/β-catenin signaling, and induces cell cycle arrest and apoptosis.