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Natural Product Categories Natural Product Categories Cucurbitales
Cucurbitales is an order of flowering plants that includes families such as Cucurbitaceae (melons, cucumbers, gourds) and Begoniaceae. Members produce a wide range of secondary metabolites including cucurbitacins, triterpenoids, flavonoids, and glycosides. In biomedical research, Cucurbitales is highly significant due to the strong cytotoxic, anticancer, anti-inflammatory, and hepatoprotective activities of cucurbitacins. The order is also important for studying plant defense chemistry and metabolic specialization in rapidly growing herbaceous species.
- Cucurbitacin BDATISCACIN, Cuc B, AmarineT34046199-67-3Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.
- $44
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Cited - Gypenoside XLIXT298594987-08-3Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition
- $35
SizeQTY - 3,29-Dibenzoyl RarounitriolT5S1028873001-54-83,29-Dibenzoyl rarounitriol is the main active compound of the polychlorinated alkane triterpene esters in Trichosanthes kirilowii and can be used as a quantitative marker of Trichosanthes kirilowii.
- $33
SizeQTY - Trigonelline chlorideTrigonelline hydrochloride, Nicotinic acid N-methylbetaine Hydrochloride, Gynesine Hydrochloride, Coffearine HydrochlorideT29276138-41-6Trigonelline chloride (Coffearine Hydrochloride), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
- $37
SizeQTY - Cucurbitacin INSC-521777, JSI-124, Elatericin BTQ01962222-07-3Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.
- $77
SizeQTY Cited - Mogroside IIeTN105688901-38-6Mogroside IIe is a bitter triterpenoid saponin which is the main component of unripe Luo Han Guo fruit and a precursor of the commercially available sweetener mogroside V.
- $53
SizeQTY - Tubeimoside IITubeimoside-BT4S1848115810-12-3Tubeimoside II (also known as Tubeimoside-B), a natural oleanane-type triterpenoid saponin analogue, exhibits anti-inflammatory, antitumor, and antitumor-promoting properties.
- $44
SizeQTY - TrigonellineTrigenollineT2887535-83-1Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
- $33
SizeQTY Cited - Cucurbitacin ET5S146718444-66-1Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has potent anti-proliferative, antineoplas
- $54
SizeQTY - Gypenoside LTN172194987-09-4Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities.
- $108
SizeQTY - GrosvenorineGrosvenorinTN1714156980-60-8Grosvenorine (Grosvenorin) exhibits good antibacterial and antioxidant activities, with its metabolites possessing more potent activities, intestinal bacteria play an important role in the gastrointestinal metabolism of grosvenorine and significantly affect its pharmacological activities.
- $88
SizeQTY - BryodulcosigeninTN14554965-97-3Bryodulcosigenin has anti-inflammatory effect, it shows potent inhibitory effects on EBV-EA induction.
- $68
SizeQTY - mogroside IVT3S119689590-95-4Mogrosides IV is a sweet minor cucurbitane glycoside, it exhibits maltase inhibitory effect(IC50 : 10 mM), and with antioxidant, antidiabetic and anticancer activities.
- $33
SizeQTY - Mogroside IIA1Mogroside II-A1TN193488901-44-4Mogroside IIA1 (Mogroside II-A1) is isolated from the fruits of Siraitia grosvenorii. Mogroside IIA1 is a a nonsugar sweetener and sweeter than sucrose. Mogroside IIA1 possesses antioxidant, antidiabetic and anticancer activities.
- $43
SizeQTY - Mogroside VT297888901-36-4Mogroside V is a widely used sweetener, has in vitro AMPK activating effect, it also has anti-inflammatory potential in murine macrophages and a murine ear edema model, and has the potential to protect against LPS-induced airway inflammation in a model of ALI. Mogroside V has antioxidant properties and possesses tumor growth inhibitory activity in pancreatic cancer models.
- $67
SizeQTY Cited - Tubeimoside ITubeimoside-1, Lobatoside-HT2715102040-03-9Tubeimoside I (Tubeimoside-1)(Lobatoside-H) is an extract from Chinese herbal medicine Bolbostemma paniculatum (MAXIM).
- $30
SizeQTY Cited - Cucurbitacin IIbT4S146950298-90-31. Cucurbitacin IIb is one of the major active compounds in Hemsleyadine tablets which have been used for clinical treatment of bacillary dysentery, enteritis and acute tonsilitis. 2. Cucurbitacin IIb exhibits its anti-inflammatory activity through modula
- $71
SizeQTY - Mogroside IV-Emogroside IveT830088915-64-4Mogroside IV-E is a triterpenoid glycoside isolated from the extracts of Luo Han Guo. Mogrosides exhibit antidiabetic, antioxidant and anticancer activities.
- $38
SizeQTY - Isocucurbitacin BTN177617278-28-3Isocucurbitacin B has significant activities against HeLa and HT-29 human cancer cells with IC50 values ranging from 0.93 to 9.73uM.
- $198
SizeQTY - 3,29-O-DibenzoyloxykarounidiolTN1025389122-01-43,29-O-Dibenzoyloxykarounidiol is a natural product with regulate blood sugar level, has potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).
- $57
SizeQTY - Cucurbitacin DTN10133877-86-9Cucurbitacin D, a triterpenoid isolated from Ecballium elaterium (L.), exhibits anticancer and antitumor activity, inhibits glucose uptake and lactate production in metastatic PrC, and induces inflammasome activation independent of ERK1/2 activation. Cucurbitacin D, a novel inflammasome activator in macrophages, inhibits HepG2 cell proliferation and induces apoptosis by modulating the JAK/STAT3, PI3K/Akt/mTOR and MAPK signaling pathways, and can be used in the study of cervical cancer, leukemia, and prostate cancer.
- $68
SizeQTY - Mogroside IV-ATN193788901-41-1Mogroside IVa is a triterpene glycoside isolated from Luo Han Guo extract. It is a non-sugar sweetener.Mogroside is sweeter than sucrose and has antioxidant, antidiabetic, and anticancer properties.
- $118
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