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Natural Product Categories Natural Product Categories Gentianales
Gentianales is an order of flowering plants that includes families such as Rubiaceae, Apocynaceae, and Gentianaceae, containing medicinal plants like coffee, cinchona, and gentian. Members of this order are rich in alkaloids, iridoids, indole derivatives, and secoiridoids. In biomedical research, Gentianales is highly important due to its strong pharmacological activities, including antimalarial (quinine from cinchona), anticancer, anti-inflammatory, and neuroactive effects. The order is a major source of clinically relevant natural products and plays a central role in drug discovery and pharmacognosy.
- SwertianolinBellidifolin-8-O-GlucosideT5S225423445-00-31. Swertianolin (Bellidifolin-8-O-Glucoside), mangiferin, rhodenthoside A-C, isoorientin, isovitexin, and amarogentin would serve as potential chemotaxonomic markers to differentiate Gentianaceae species. 2. Swertianolin and swertiamarin show significant hepatoprotective effect in the liver damage model induced by alpha-naphthylisot hiocyanate. 3. Swertianolin shows anti-acetylcholinesterase activity effects. 4. Swertianolin shows that it can scavenge superoxide and hydroxyl radicals with the studying method of the autoxidation of Pyrogallol and afenton.
- $53
SizeQTY - Asperulosidic acidASPATN141025368-11-0Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways.
- $129
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Cited - β-Amyrinbeta-AmyrinTN1027559-70-6β-Amyrin (beta-Amyrin) has antiviral, hepatoprotective, antinociceptive, anti-inflammatory
- $84
SizeQTY - AucubinRhinanthin, AucubosideT3416479-98-1Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.
- $35
SizeQTY Cited - Vinblastine sulfateVincaleukoblastine sulfate salt, NSC49842T1668143-67-9Vinblastine sulfate (Vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).
- $50
SizeQTY Cited - Trachelogenin(-)-TrachelogeninTN650834209-69-3Trachelogenin ((-)-Trachelogenin), isolated from Combretum fruticosum, is an HCV entry inhibitor with anti-proliferative effects. Its mechanism is related to affecting the phosphorylation of key proteins such as β-Catenin, c-Myc and GSK3 in the β-Catenin signaling pathway. chemical and concentration-dependent. Trachelogenin has antiviral, anti-inflammatory and analgesic activities with IC50 of 0.325 and 0.259 μg/mL in HCVcc and HCVpp models, respectively.
- $139
SizeQTY - StrictosamideTN223923141-25-5Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.AktAntifungalATPaseInterleukinJNKNF-κBNO Synthasep38 MAPKParasitePERKPI3KPotassium ChannelSodium Channel
- $48
SizeQTY - Vincristine sulfateLeurocristine sulfate, Leurocristine, 22-Oxovincaleukoblastine sulfateT12702068-78-2Vincristine sulfate is an alkaloidal natural product that binds to microtubule proteins and inhibits the formation of microtubules, thereby inhibiting mitosis in tumor cells. Vincristine sulfate is used as a microtubule destabilizing agent in research studies for the treatment of hematologic neoplasms such as leukemias and lymphomas, as well as in studies related to sarcomas in children.
- $32
SizeQTY Cited - Jolkinolide BT2S104037905-08-1Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can be used for studies on preventing and treating osteolysis.
- $60
SizeQTY - PeriplocinPeriplocosideT5S198213137-64-91. Periplocin (Periplocoside) has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway. 2. Periplocin is used for treatment of rheumatoid arthritis, reinforcement of bones and tendons, palpitations or shortness of breath and lower extremity edema in traditional medicine.
- $30
SizeQTY - Caffeic AcidT2807331-39-5Caffeic acid is a dual inhibitor of 5-lipoxygenase and TRPV1 ion channels.
- $29
SizeQTY Cited - 8-HydroxyapigeninIsoscutellareinTN235341440-05-58-Hydroxyapigenin (Isoscutellarein) is a brassinaceous compound derived from the plant Scutellaria baicalensis with anti-inflammatory, antioxidant and anti-influenza virus activity.
- $98
SizeQTY - QuinidineT793856-54-2Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent. for the treatment of abnormal heart rhythms and also malaria.
- $30
SizeQTY Cited - IsotrifoliinIsoquercitroside, IsoquercetinT490221637-25-2Isotrifoliin (Isoquercitroside)n is an effective antioxidant and an eosinophilic inflammation suppressor.
- $29
SizeQTY Cited - PeriplogeninDesoxostrophanthidin, 5-beta-HydroxydigitoxigeninT4S1983514-39-61. Periplogenin (Desoxostrophanthidin) plays protective roles against thyrotoxicosis and associated cardiovascular problems, are mediated through its direct antithyroidal and/or LPO inhibiting properties.
- $41
SizeQTY - HumantenmineT2S066382354-38-91. Humantenmine is a toxic compound isolated from Gelsemium elegans Benth . 2. Humantenmine and koumine may inhibit several CYP450 enzyme activities.
- $40
SizeQTY - TrachelosideT385533464-71-0Tracheloside significantly decreases the activity of alkaline phosphatase (IC50: 0.31 μg/ml), a level of inhibition comparable to that of tamoxifen (IC50: 0.43 μg/ml).
- $37
SizeQTY - 3-Feruloylquinic acid3-O-Feruloylquinic acidTN12621899-29-23-O-Feruloylquinic acid is a protease inhibitor, it exerts moderate inhibitory effect against AIV (H5N1) in vitro.
- $163
SizeQTY - beta-Amyrin acetateTN14381616-93-9beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 μM. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities.
- $59
SizeQTY - 4-VinylphenolT135092628-17-34-Vinylphenol is the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine found in Hedyotis diffusa Willd. 4-Vinylphenol induces apoptosis in vivo.
- $36
SizeQTY - LoganetinT575729748-10-5Loganetin, a non-toxic natural product, shows antibacterial activity against multidrug-resistant Gram-negative infections.
- $40
SizeQTY - AsperulosideAsperulosidT384714259-45-1Asperuloside (Asperulosid) has anti-inflammatory activity.
- $55
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