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Natural Product Categories Natural Product Categories Cornales
Cornales is an order of flowering plants within the asterid clade, including families such as Cornaceae, which contains ecologically and medicinally significant genera like Cornus (dogwoods). Members of Cornales produce diverse secondary metabolites including iridoids, phenolic acids, flavonoids, and triterpenoids, which contribute to their defense mechanisms and pharmacological potential. In biomedical research, Cornales is important for its anti-inflammatory, antioxidant, hepatoprotective, and anticancer properties observed in various species. The order is also valuable for chemotaxonomic studies, as its metabolite profiles help clarify evolutionary relationships among early-diverging asterids. Due to its combination of ornamental, ecological, and pharmacologically active species, Cornales serves as a useful bridge between natural product discovery and evolutionary plant science.
- Forsythoside BT389381525-13-5Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response and has antioxidant properties. Potent neuroprotective effects with a favorable therapeutic time
- $33
SizeQTY - CephaelineTN1480483-17-0Cephaeline was highly active against protected primary CLL cells (relative IC50's 35nM ) and acted by repressing HIF-1α± and disturbing intracellular redox homeostasis.
- $123
SizeQTY - HalofuginoneTempostatin, RU-19110T685655837-20-2Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
- $31
SizeQTY - 10-MethoxycamptothecinT4S195119685-10-010-Methoxycamptothecin, a natural bioactive derivative of camptothecin (CPT) isolated from *Camptotheca acuminata*, exhibits potent anti-cancer properties.
- $35
SizeQTY - EvodiamineIsoevodiamine, d-Evodiamine, (+)-EvodiamineT2868518-17-2Evodiamine (d-Evodiamine) is an alkaloid isolated from the fruit of daylily and has a variety of biological activities including anti-inflammatory, anti-obesity and anti-tumor.
- $30
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Cited - HydrangenolTN4234480-47-7In houseHydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can reduce MMP and inflammatory cytokine expression and increase moisturizing factors and antioxidant genes level, result in preventing wrinkle formation.
- $139
SizeQTY - CamptothecinNSC-100880, CPT, Campathecin, (S)-(+)-CamptothecinT11237689-03-4Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.
- $46
SizeQTY Cited - Forsythoside IT82771177581-50-8Forsythoside I, a caffeoyl phenylethanoid glycoside (CPG), may have anti-inflammatory properties.
- $44
SizeQTY - VincosamideTN229823141-27-7Vincosamide is an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity. Vincosamide can effect relaxation of the supercoiled pBR322 plasmid DNA in the presence of Cu2+.
- $148
SizeQTY - PhillygeninSylvatesmin, Phillygenol, Forsythigenol, Epipinoresinol methyl ether, (+)-PhillygeninT3S1089487-39-81. Phillyrin, (+)-Phillygenin (Sylvatesmin), and (-)-phillygenin exert the strongest inhibitory activities on NO production with IC(5) values.
- $34
SizeQTY - Forsythoside ET5S109493675-88-8Forsythoside E is a natutal product isolated from fruits of forsythia suspensa.
- $44
SizeQTY Cited - Oleoside 11-methyl esterMethyloleosideTN456260539-23-3Oleoside 11-methyl ester (Methyloleoside) is a natural product.
- $96
SizeQTY - 9-MethoxycamptothecinT5S195239026-92-19-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.
- $48
SizeQTY Cited - CornusideComuside, 7-O-Galloylsecologanol, 7-GalloylsecologanolT4S2326131189-57-61. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses. 4. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells. 5. Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.
- $36
SizeQTY Cited - PhillyrinForsythinT2854487-41-2Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation. Phillyrin(Forsythin) may be a new preventive agent of acute lung injury in the clinical setting, it potentially contributes to the suppression of the activation of MAPK and NF-κB pathways, it also has protective effects on H2O2-induced oxidative stress and apoptosis in PC12 cells.
- $39
SizeQTY Cited - (S)-10-Hydroxycamptothecin10-Hydroxycamptothecin, 10-HCPTT276419685-09-7(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor used as a clinical therapeutic agent against hepatoma.
- $51
SizeQTY - VerbenalinVerbenaloside, Verbenalol β-D-glucopyranoside, Verbenalol glucoside, CorninT3890548-37-8Verbenalin (Verbenaloside) induces angiogenesis via a programmed PI3K/Akt/eNOS/VEGF signaling axis.
- $30
SizeQTY - Forsythoside HTN16481178974-85-0Forsythoside H is a nartural product from Forsythia suspense (Thunb.) Vahl.
- $64
SizeQTY - IsoforsythiasideT3S10881357910-26-9Isoforsythiaside has antioxidant, and antibacterial activities.
- $30
SizeQTY Cited - RutaecarpineRutecarpine, Rutacarpine, RhetineT297284-26-4Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM.
- $33
SizeQTY - Forsythiaside AForsythoside A, ForsythiasideT367079916-77-1Forsythiaside A (Forsythiaside) has antimicrobial, anticomplementary, anti-inflammatory and antiendotoxin activities. Forsythiaside A inhibits Infected cells was confirmed by infecting primary chicken embryo kidney cells.
- $31
SizeQTY Cited - (±)-10-Hydroxycamptothecin(±)10Hydroxycamptothecin, (±) 10 HydroxycamptothecinT152164439-81-2(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
- $30
SizeQTY Cited - Cephaeline dihydrochlorideNSC32944, NSC 32944, (-)-Cephaeline dihydrochlorideTQ01095853-29-2Cephaeline dihydrochloride is a naturally occurring alkaloid that is a selective CYP2D6 inhibitor with an IC50=121 μM. It has an affinity for and oral activity at the 5-HT4 receptor and is capable of inducing vomiting.
- $42
SizeQTY - 12-Ethyl-9-hydroxycamptothecin7-Ethyl-10-Hydroxy-CamptothecinTN2460119577-28-512-Ethyl-9-hydroxycamptothecin (SN38) is the active metabolite of irinotecan, a topoisomerase I inhibitor, with potential anticancer activity for use in the study of colon and rectal cancer.
- $40
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