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Aquaporin

Aquaporins (AQP) are integral membrane proteins that serve as channels in the transfer of water, and in some cases, small solutes across the membrane. They are conserved in bacteria, plants, and animals. Structural analyses of the molecules have revealed the presence of a pore in the center of each aquaporin molecule.

  • Atorvastatin Sodium
    T20887134523-01-6In house
    Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors on hepatocytes. Atorvastatin Sodium treatment inhibits aquaporin 4 to reduce ischaemic brain oedema.
    • $50
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  • DFP00173
    T11014672286-03-2In house
    DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with IC50 of ~0.1-0.4 μM. Compared with the homologous AQP subtypes AQP7 and AQP9, DFP00173 is selective for AQP3.
    • $116
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  • TGN-020
    T510251987-99-6
    TGN-020 is an inhibitor of Aquaporin 4 (AQP4, IC50: 3.1 μM), the most abundant water channel in the brain.
    • $47
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    TargetMol | Citations Cited
  • p-Tolylmaleimide
    T210441631-28-3
    p-Tolylmaleimide (p Tolylmaleimide) is an inhibitor of the water channel and binds to Aquaporin Z.
    • $40
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    TargetMol | Inhibitor Sale
  • TC-AQP1-1
    T2485937710-81-9
    TC-AQP1-1 is a blocker of the aquaporin 1 channel identified by virtual screening and inhibits water flux through hAQP1 in Xenopus laevis oocyte swelling assays at low micromolar concentrations.
    • $59
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  • AER-271
    T7946634913-39-6
    AER-271 is an inhibitor of aquaporin-4.
    • $37
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