spermine

Spermine (Neuridine) is an endogenous polyamine in the human body. As a direct free radical scavenger, it exhibits antiviral activity and protects DNA from free radical damage; it is also a key regulator of cell proliferation, differentiation, and apoptosis. Spermine inhibits certain bacteria, particularly strains of Staphylococcus aureus. Spermine induces striatal neurotoxicity in a dose-dependent manner. Spermine reversibly inhibits DNA synthesis, mixed lymphocyte reactions, and the induction of cytolytic lymphocyte reactions in primary cultures of mouse splenocytes.

Spermine tetrahydrochloride (Musculamine tetrahydrochloride) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is a major natural intracellular compound capable of protecting DNA from free radical attack.

Benzazepinoquinoline-spermine (Compound PA-3) is a potent complexing agent for pre-miR-372 that specifically inhibits its processing mediated by Dicer, with an IC₅₀ of 0.58 μM. It exhibits strong affinity for pre-miR-372, with a KD of 0.11 μM, and shows high activity against pre-miR-373 (IC₅₀= 0.29 μM). However, its inhibitory effect is significantly reduced for pre-miR-17, pre-miR-21, and pre-miR-155, with IC₅₀ values of 0.84 μM, 1.43 μM, and 1.07 μM, respectively. Benzazepinoquinoline-spermine is applicable in cancer research.

Spermine Prodrug-1 is a redox-sensitive spermine prodrug. Spermine Prodrug-1 inhibits wild-type (CMS-24949) and spermine synthase gene (SMS) mutant (CMS-26559, and CMS-6233) fibroblasts with IC50 values of 326.7. 198.5, and 244.1 μM, respectively. Spermine Prodrug-1 can be used in the treatment of Snyder Robinson syndrome.

Spermine (N3BBB), a click chemistry reagent with an azide group, facilitates diverse biochemical studies [1].

N1-Azido-spermine trihydrochloride (Spermine[HHHN3]) is a click chemistry agent featuring an azide group.

Spermine-D8 tetrahydrochloride is the deuterated form of Spermine tetrahydrochloride (TMSM-2110), which is an endogenous metabolite.

Spermine-15N2 (NSC 268508-15N2) is the 15N-labeled version of Spermine. This compound acts as a natural antioxidant and anti-inflammatory agent. Spermine is effective in inhibiting certain bacterial cultures, particularly strains of Staphylococcus aureus, and induces dose-dependent neurotoxicity in the striatum. It can reversibly inhibit DNA synthesis reactions, mixed lymphocyte reactions, and cytotoxic lymphocyte responses in primary cultures of mouse splenocytes. As a polyamine nitric oxide donor, Spermine tetrahydrochloride supplies nitric oxide to platelets and inhibits platelet activation in a concentration-dependent manner. This compound is present in mammalian tissues, plants, bacteria, ribosomes, and bacteriophages, and it can inhibit primary human embryonic lung fibroblast cells in vitro.

Spermine-D8 Tetrahydrochloride (Standard) is a reference standard of Spermine-D8 Tetrahydrochloride intended for quantitative analysis, quality control, and related biochemical research applications. Spermine-d8 (tetrahydrochloride) is the deuterated form of spermine tetrahydrochloride, which is an endogenous metabolite.

Bis(glutathionyl)spermine disulfide is a nucleoside metabolite.

N4,N9-di-Boc-spermine is a spermine linker characterized by two Boc-protected amine groups and two additional amine groups. The Boc groups can be removed under mild acidic conditions to yield free amines. These amino groups can react with carboxylic acids, activated NHS esters, and carbonyl compounds (ketones, aldehydes). Spermidine, a polyamine, plays a role in regulating various cellular activities including cell growth and differentiation, DNA stability, and apoptosis.

N1,N12-Di-Boc-spermine is a spermine derivative that contains two Boc-protected amino groups. The Boc groups can be removed under mild acidic conditions to yield free amines. Spermidine, a related polyamine, plays a role in regulating diverse cellular processes, such as cell growth and differentiation, DNA stability, and apoptosis.

N-(4-Hydroxyphenylacetyl)spermine is a NMDA receptor antagonist.

Spermine (Standard) is the reference standard of spermine, suitable for quantitative analysis, quality control, biochemical experiments, and related research. Spermine (neuridine) acts as a direct free radical scavenger with antiviral effects and protects DNA from free radical attack.

Spermine tetrahydrochloride (Standard) is the standard substance of Spermine tetrahydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Spermine tetrahydrochloride (Musculamine tetrahydrochloride) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is a major natural intracellular compound capable of protecting DNA from free radical attack.

Naspm is a synthetic analogue of Joro spider toxin and is a antagonist iscalcium permeable AMPA (CP-AMPA) receptors.

Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and acts as an antagonist of calcium-permeable AMPA (CP-AMPA) receptors.

GL67 (N4-Spermine cholesteryl carbamate), a cationic lipid, facilitates the delivery of nucleic acid agents and vaccines, and is effective in gene transfection [1].

GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. It is utilized for the delivery of nucleic acid active molecules, vaccines, and for gene transfection.

N1-Acetylspermine trihydrochloride is a monoacetylated derivative of spermine, an endogenous polyamine. N1-Acetylspermine trihydrochloride can be used in research on polyamine metabolism, tumor biology, and neurodegenerative diseases.

Thermospermine is a structural isomer of spermine that plays a role in inhibiting xylem differentiation and can enhance the translation of SAC51 and SACL1 in Arabidopsis thaliana. Thermospermine is also used in studies as a plant growth regulator and for controlling wood biomass production.

Diethylnorspermine HCl (N1,N11-Diethylnorspermine tetrahydrochloride) potently induces SSAT (spermidine/spermine N1-acetyltransferase) mRNA and effectively stabilizes SSAT enzyme activity.

Norspermine is a polyamine analogue ,used in the treatment of non-small cell lung carcinoma and breast cancer.

N1,N12-Diacetylspermine dihydrochloride (Diacetylspermine 2HCl) is a diacetylated derivative of Spermine. The occurrence of cancer is associated with the up-regulation of N1,N12-Diacetylspermine dihydrochloride, making it a biomarker to detect cancer occurrence.