sis-3

SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation, effectively inhibiting the TGF-β1-induced myofibroblast differentiation of fibroblasts.

(E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) and is selective. (E)-SIS3 inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1.

Volanesorsenscramble negative control is the negative control form of Volanesorsen with the sequence: CAUGUTCUTCUGCATGUCAU. Volanesorsen (ISIS 304801) is an antisense oligonucleotide inhibitor targeting apolipoprotein CIII (apo-CIII) mRNA, effectively reducing triglyceride levels and improving insulin resistance.

Tofersen (BIIB067) is an antisense oligonucleotide (ASO) that mediates RNase H-dependent degradation of SOD1 (superoxide dismutase 1) mRNA, inhibiting SOD1 protein synthesis for potential use in amyotrophic lateral sclerosis (ALS).

Volanesorsen (ISIS 304801) is a chemically stabilized antisense oligonucleotide that selectively inhibits apolipoprotein CIII messenger RNA, resulting in reduced triglyceride levels and improved insulin sensitivity, Volanesorsen is actively studied as a targeted nucleic acid therapeutic strategy for hypertriglyceridemia, familial chylomicronemia syndrome, and type 2 diabetes.

Tofersen-d27 (BIIB067-d27) is the deuterated form of Tofersen. Tofersen (BIIB067) is an antisense oligonucleotide that mediates the RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA, thereby reducing the synthesis of SOD1 protein. Tofersen is utilized in research related to amyotrophic lateral sclerosis (ALS).

Cilengitide hydrochloride sis the salt form of Cilengitide, a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.