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sis-3

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    3
    TargetMol | Inhibitors_Agonists
  • Recombinant Protein
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    TargetMol | Recombinant_Protein
  • Antibody Products
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    TargetMol | Antibody_Products
(E)-SIS3
SIS3 HCl, SIS3 hydrobromide
T3636521984-48-5
(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts and inhibits TGF-β2-induced endothelial cell differentiation in iPSCs.
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(Rac)-SIS3 free base
T129231009104-85-1
SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation, effectively inhibiting the TGF-β1-induced myofibroblast differentiation of fibroblasts.
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6-8 weeks
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Cilengitide hydrochloride
T70083188969-00-8
Cilengitide hydrochloride sis the salt form of Cilengitide, a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.
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10-14 weeks
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