sir2

Parishin (Parishin A) A is isolated from the rhizomes of Gastrodia elata. It has good neuroprotective effects against brain disorders.

Nicotinamide, a vitamin B3 derivative, is an inhibitor of SIRT1 (IC50=50-180 μM) and SIRT2 (IC50=2 μM). Nicotinamide can be used as a precursor of nicotinamide adenine dinucleotide or NAD+, which can be supplemented by dietary intake and can prevent or treat melanoglossia and pellagra.

Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).

Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.

Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1, such as resveratrol, extend lifespan in yeast and C. elegans in a manner that resembles caloric restriction. CAY10591 has been identified as an activator of the enzyme SIRT1. This compound increases fluorescence by 233% in a SIRT1 activity assay. [Activator activity was defined as the percentage of signal increase relative to signal window in the following formula: 100 x (Sample - Signallow)/(Signalhigh - Signallow)]. CAY10591 suppresses TNF-α in a dose-dependent manner. In THP-1 cells, TNF-α levels decreased from 325 pg/ml (control) to 104 and 53 pg/ml with 20 and 60 µM CAY10591, respectively. This activator also has a significant dose-dependent effect on fat mobilization in differentiated adipocytes, which would indicate the potential of SIRT1 activators for anti-obesity or anti-diabetic purposes.

2-Dodecanol suppresses both hyphal development and SIR2 gene expression in Candida albicans [1].

2-Dodecanol (Standard) is the standard substance of 2-Dodecanol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 2-Dodecanol suppresses both hyphal development and SIR2 gene expression in Candida albicans.

Parishin (Standard) is a reference standard for research and analysis in studies involving Parishin. Parishin (Parishin A) A is isolated from the rhizomes of Gastrodia elata. It has good neuroprotective effects against brain disorders.