sb-4

BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)

SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective. SB 431542 also has inhibitory activity against ALK4 and ALK7 but not other proteins. SB 431542 can be used for induced differentiation of stem cells.

SB-408124 Hydrochloride is a non-peptide OX1 receptor antagonist(Ki of 57 nM and 27 nM in both whole cell and membrane, respectively).

SB-423557 is an orally active antagonist of the calcium-sensing receptor (CaR), demonstrating an IC50 of 520 nM.

SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.

SB-405483 is a CRBN (Cereblon) positive modulator that facilitates the degradation of CRBN substrates, which include CK1α, Wee1, and IKZF1/3. Furthermore, SB-405483 stabilizes CRBN and reduces its own ubiquitination levels. This compound is applicable in cancer research, such as in studies on multiple myeloma and acute myeloid leukemia.

SB-414796 is a selective antagonist of the dopamine D3 receptor.

SB-429201 is an effective, selective inhibitor of HDAC1.

SB-423562 is a calcium-sensing receptor antagonist.

SB-436811 is an antagonist of human urotensin-II receptor.

SB-410220 is a bioactive chemical.

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.

SB-435495 is an orally active, selective and potent Lp-PLA2 inhibitor (IC50 of 0.06 nM) for the study of autoimmune uveitis and atherosclerosis.

SB-435495 hydrochloride is a potent, selective, reversible, non-covalent, and orally active inhibitor of Lp-PLA2, with an IC50 of 0.06 nM [1] [3].

SB-435495 ditartrate is a potent, selective, reversible, non-covalent, and orally active Lp-PLA2 inhibitor with an IC50 of 0.06 nM [1] [3].

PSB-SB-487 is antagonist of GPR55.

Eltrombopag (SB-497115-GR), an orally active thrombopoietin receptor agonist with megakaryopoiesis stimulating activity, binds to and stimulates the platelet thrombopoietin receptor (TPO-R or CD110).

Eltrombopag Olamine (Eltrombopag diethanolamine salt) is an orally active small-molecule, nonpeptide thrombopoietin receptor agonist that stimulates megakaryopoiesis. It binds to and activates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), promoting the proliferation and differentiation of megakaryocytic cells and enhancing platelet production.

SB405483 is a CRBN (cereblon) orthosteric ligand-binding enhancer that promotes the ubiquitination and proteasomal degradation of CRBN substrates (such as CK1α, Wee1, and IKZF1/3) by stabilizing the CRBN protein conformation and enhancing its binding affinity for substrates. SB405483 can be used in cancer research, such as in multiple myeloma and acute myeloid leukemia.

(E/Z)-Eltrombopag-13C4 is a mixture complex of E-Eltrombopag and Z-Eltrombopag, with 13C labeled. Z-Eltrombopag is a thrombopoietin (TPO) receptor agonist developed for certain conditions that lead to thrombocytopenia.

Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II). It also has an antithrombotic activity associated with a reduced risk of adverse bleeding events.

HSB401 is an orally active FLT3 inhibitor with IC50 values of 28, 5, 72, and 51 nM for FLT3-WT, FLT3-D835Y, FLT3-ITD-F691L, and FLT3-ITD, respectively. It downregulates the FLT3 signaling pathway, inducing cell cycle arrest and apoptosis. HSB401 does not inhibit c-KIT, which reduces the risk of bone marrow suppression. In the MV4-11 xenograft mouse model, HSB401 significantly suppresses tumor growth and is applicable for research in acute myeloid leukemia (AML).

SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).

SB 414240 is a bioactive chemical.