pde10

PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.

SEP-0372814 is a potent inhibitor of PDE10.

PDE2/PDE10-IN-1 is an inhibitor of phosphodiesterase 2 (PDE2) and PDE10, with IC50 values of 29 nM and 480 nM, respectively.

PDE10-IN-5, a phosphodiesterase 10 (PDE10) inhibitor, is utilized for studying certain central nervous system disorders.

PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.

PDE10A-IN-8 is a potent inhibitor of PDE10A.

Compound 8a (PDE10A-IN-3) serves as an inhibitor of phosphodiesterase 10A (PDE10A) and is utilized in schizophrenia research [1].

Sp-cAMPS sodium salt is an analog of cAMP that serves as a potent activator of cAMP-dependent PKA I and PKA II, and as a competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 μM. It also binds the PDE10 GAF domain with an EC50 of 40 μM [1] [2] [3].

BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).

PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.

Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.

N-Methylbenzamide is a potent inhibitor of phosphodiesterase 10A (PDE10A) with demonstrated anti-cancer activity.

MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, Ki = 0.029nM, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.

(1R,2R)-MK-8189 is an isomer of MK-8189 and can be used for biochemistry experoments. MK-8189 is a potent and selective pyrimidine PDE10A inhibitor.

PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.

PDE9-IN-(S)-C33 ((S)-C33) is a potent and selective inhibitor of PDE9 (IC50 = 11 nM). PDE9-IN-(S)-C33 can be used for central nervous system diseases and diabetes research.

Rp-cAMPS TEA salt is a cAMP-dependent protein kinase (PKA) activator.

Avanafil dibesylate is a PDE5 inhibitor.

Sp-cAMPS triethylamine, a cAMP analog, serves as a potent activator of cAMP-dependent PKA I and II, and acts as a competitive inhibitor of phosphodiesterase (PDE3A) with a K i of 47.6 µM. Additionally, it binds the PDE10 GAF domain with an EC 50 of 40 μM [1] [2] [3].

MT-3014 is a potent, highly selective, and brain-penetrant inhibitor of phosphodiesterase 10A (PDE 10A), with IC50 values of 0.062 nM for human PDE 10A and 0.09 nM for bovine PDE 10A.

PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5 (IC50 of 0.31 nM).

TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.

AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).

PF-05180999 (PF-999) is a selective and potent phosphodiesterase 2A (PDE2A) inhibitor that enhances long-term memory in a contextual fear conditioned reflex model in rats.