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Results for "

orexin receptor

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    63
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    13
    TargetMol | Peptide_Products
  • Recombinant Protein
    1
    TargetMol | Recombinant_Protein
  • Isotope Products
    1
    TargetMol | Isotope_Products
Orexin receptor activator-1
T2007073038645-77-8
Orexin Receptor Activator-1 is an agonist for the orexin receptor (Orexin Receptor). It is utilized in the research of orexin-related disorders.
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3-6 months
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Orexin receptor antagonist 2
T381391457940-75-8
Orexin Receptor Antagonist 2 (compound 30), characterized by its potent antagonistic activity with pKis of 7.69 and 9.78, holds promise for insomnia research[1].
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6-8 weeks
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orexin receptor antagonist 4
T620502251017-69-1
Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist. Orexin receptor antagonist 4 shows IC50 of 4.27 nM and 295 nM for OX2R and OX1R, respectively.
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8-10 weeks
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Orexin receptor antagonist 3
T624531293282-55-9
Orexin receptor antagonist 3 (example 216) functions as an orexin receptor antagonist.
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6-8 weeks
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Orexin receptor modulator-1
T790562125735-57-9
Orexin Receptor Modulator-1 is a compound utilized in the study of various conditions including substance addiction, panic disorder, anxiety, post-traumatic stress disorder (PTSD), pain, depression, seasonal affective disorder (SAD), eating disorders, and hypertension [1].
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8-10 weeks
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Orexin 2 Receptor Agonist
OX2R
T31771796565-52-0
Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R OX2R EC50 ratio: 70) agonist.
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TargetMol | Inhibitor Sale
Orexin 2 Receptor Agonist 2
T395612114324-60-4
Orexin 2 Receptor Agonist 2 (ORA-2) is a specific agonist for the orexin 2 receptor.
    7-10 days
    Inquiry
    TargetMol
    Suntinorexton
    TAK861, TAK 861
    T398072274802-89-8In house
    Suntinorexton (TAK 861) is an orexin type 2 receptor (OX2R) agonist for the study of neurological disorders.
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    jnj-54717793
    T96541628843-99-1In house
    JNJ-54717793 is an orally active, brain-penetrating compound that acts as a selective and high-affinity antagonist of the orexin-1 receptor (OX1R) with a plasma EC50 of 85 ng mL. It demonstrates K_i values of 16 nM for hOX1R (human OX1R) and 700 nM for hOX2R, indicating its strong preference for hOX1R over hOX2R. JNJ-54717793 is recognized for its effectiveness in the treatment of anxiety disorders.
      7-10 days
      Inquiry
      oxa(17-33)
      OXA (17-33)
      TP1973343268-91-7
      Potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A.
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      TCS 1102
      DORA-1
      T2710916141-36-1
      TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2 3 nM for OX2 1 receptors).
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      TargetMol | Inhibitor Sale
      SB-649868
      GSK649868
      T5498380899-24-1
      SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).
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      TargetMol | Inhibitor Sale
      Orexin B, rat, mouse Acetate
      Rat orexin B, Orexin B (mouse) Acetate, Orexin B, rat, mouse Acetate(202801-92-1 free base)
      TP1045L
      Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
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      TargetMol | Inhibitor Sale
      OXA (17-33) acetate
      TP1973L
      OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).
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      TargetMol | Inhibitor Sale
      EMPA
      T11186680590-49-2
      EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectively)
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      GSK1059865
      T114771191044-58-2
      GSK1059865 is a potent antagonist of the orexin 1 receptor.
      • Inquiry Price
      6-8 weeks
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      Seltorexant
      JNJ-42847922
      T12877L1293281-49-8
      Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human and rat OX2R).
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      Filorexant
      MK-6096
      T160961088991-73-4
      Filorexant (MK-6096) is an orally bioavailable, effective, and selective reversible antagonist of OX1 and OX2 receptors, with (Ki <3 nM).
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      MK-3697
      T19131224846-01-8
      MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).
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      Oveporexton
      T2008542460722-04-5
      Oveporexton is an agonist for the type 2 orexin receptor (OX2R).
      • Inquiry Price
      3-6 months
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      OBPt-9
      OBPt9, OBPt 9
      T2024691252017-64-3
      OBPt-9 is a compound that enhances orexin receptor activity, primarily by increasing the modulation of orexin signaling.
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      (r)-ynt-3708
      (R) YNT 3708, (R)-YNT 3708, R-YNT-3708, R YNT 3708
      T2026642923137-94-2
      (R)-YNT-3708 is a specific Orexin 1 receptor (OX1R) agonist with an EC50 value of 7.48 nM for OX1R. The EC50 ratio of OX2R to OX1R is 22.5. This compound demonstrates analgesic and enhancing effects by activating OX1R in mice.
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      Alixorexton
      T2050532648347-56-0
      Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.
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      10-14 weeks
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      act 335827
      T218501354039-86-3
      ACT-335827 is an orally available, brain-penetrant, orexin type 1 receptor-selective antagonist, with IC50 values of 6 nM for OXR1 and 417 nM for OXR2. It is suitable for studies related to neurological disorders [1].
      • Inquiry Price
      8-10 weeks
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