mutagen

Urethane (Ethyl carbamate; Ethylurethane) is a byproduct formed during the fermentation process of various foods. As an ethyl ester of carbamic acid, it has the ability to inhibit the growth of bacteria, sea urchin eggs, protozoa, and plant tissues, and is commonly used for establishing lung cancer models.

N-Nitroso-N-methylurea (NMU/MNU/NMH) is a nitrosourea compound with alkylating, carcinogenic, and mutagenic properties; as a direct-acting alkylating agent, it interacts with DNA and targets multiple animal organs to induce various cancers and degenerative diseases, and is commonly used to induce disease models such as gastric cancer and breast cancer in mice.

Chlorophyllin sodium copper salt (Chlorophyllin coppered trisodium salt) is a semi-synthetic mixture of water-soluble sodium copper salts derived from chlorophyll, primarily used as a food additive and alternative medicine.

1,3-Dithiane (1,3-Dithian) is a protected formaldehyde anion equivalent that could serve as a useful labeled synthon. 1,3-Dithiane is also a sulfur-containing Maillard reaction products found in boiled beef extracts.

Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy.

9-Propenyladenine (9-PA) is a mutagenic impurity in tenofovir disoproxil fumarate (TDF).

(Z)-9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate.

Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties.Macrozamin is a natural product isolated from Cycads.

Lupeol (Monogynol B) is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity.

Bilirubin (Principal bile pigment) is a type of bile pigment, which is a metabolite of hemoglobin in the blood. Bilirubin has antimutagenic and antioxidant effects. Bilirubin is an important basis for clinical determination of jaundice, and is also an important indicator of liver function.

Harmane (Loturine) is a bio-active β-Carboline and monoamine oxidase inhibitor found in coffee and tobacco smoke.

Robinetin (3,3',4',5',7-Pentahydroxyflavone) exhibits potent antioxidant and antiradical activities, effectively inhibiting EYPC membrane lipid peroxidation and HbA glycosylation.

Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 through the Nrf2/ARE and JNK/ERK signa

DL-Glyceraldehyde (Glyceric aldehyde) is produced from the action of the enzyme glyceraldehyde dehydrogenase, which converts glycerol to glyceraldehyde using NADP as a cofactor. When present at sufficiently high levels, DL-Glyceraldehyde can be a cytotoxin and a mutagen. A cytotoxin is a compound that kills cells. A mutagen is a compound that causes mutations in DNA. DL-Glyceraldehyde is a highly reactive compound that can modify and cross-link proteins. DL-Glyceraldehyde modified proteins appear to be cytotoxic, depress intracellular glutathione levels, and induce reactive oxygen species (ROS) production (PMID: 14981296 ). DL-Glyceraldehyde has been shown to cause chromosome damage to human cells in culture and is mutagenic in the Ames bacterial test.

DL-Homocystine is a mutagen secreted by F. nucleatum.

2-Amino-3-Methylimidazo[4,5-f]quinoxaline is a food mutagen known to exhibit mutagenic activity.

Bis(diazoacetyl)butane is a mutagen and traditionally related to radio-mimetic chemical mutagens due to the similarity of appearance of mutagenic action of this mutagen and physical mutagens. It also has anti-tumor and carcinogenic activity.

Aziridyl benzoquinone, an antineoplastic agent, has been studied as a mutagen and as a carcinogenic agent.

CP 67015 has an inhibitory effect on the function of topoisomerase, and is a direct mutagen in mammalian cells, which has effects on gene and chromosome levels.

Aristolochic acid B (Aristolochic Acid II) is a natural product from the Aristolochaceae taxon and is one of the main components of aristolochic acid. Aristolochic acid is a mutagen and carcinogen, and Aristolochic acid B (Aristolochic Acid II) can show a greater carcinogenic risk in vivo than Aristolochic acid I.

Dimethylnitrosamine (NDMA) is a potent hepatotoxin, carcinogen, and mutagen, and is commonly used to establish liver tumor models.

4-OHE ((E)-4-Oxo-2-hexenal), a mutagen, originates from the peroxidation of omega-3 fats and exhibits antibacterial activity .

Acrylamide-2,3,3-D3 is a deuterated compound of Acrylamide. Acrylamide (T5553) has a CAS number of 79-06-1. Acrylamide (T5553) is a member of the class of acrylamides. It has a role as a carcinogenic agent, a neurotoxin, a mutagen, an alkylating agent and a Maillard reaction product

Dimethylnitrosamine (Standard) is a reference standard of dimethylnitrosamine suitable for quantitative analysis, quality control, and biochemical studies. Dimethylnitrosamine (NDMA) is a potent hepatotoxin, carcinogen, and mutagen commonly used to establish liver tumor models.